Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1995 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32109 |
Resumo: | Manoel Barral Neto; Barral, Aldina Maria Prado. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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Barral, Aldina Maria PradoCosta, Jackson Mauricio LopesBittencourt, Achilea Candida LisboaBarral Netto, ManoelCarvalho, Edgar Marcelino de2019-03-15T14:19:02Z2019-03-15T14:19:02Z1995BARRAL, A.M. P. et al. Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathologic aspects. International Journal of Dermatology, v. 34, n. 7, p. 474-479, 1995.0011-9059https://www.arca.fiocruz.br/handle/icict/32109Manoel Barral Neto; Barral, Aldina Maria Prado. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.United States Public Health Service Grant AI30639 and Brazilian National Research Gouncil (GNPq).Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Federal University of Maranhão. Faculty of Medicine. Department of Infectious and Parasitic Diseases. São Luís, MA, Brazil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Background. Diffuse cutaneous leishmaniasis (DCL) is a rare manifestation of human leishmaniasis, characterized by multiple, slowly progressive nodules or plaques without ulceration, involving almost the entire body. It has been suggested, that DCL results from a lack of cell-mediated immunity to leishmanial antigen, leading to uncontrolled parasite growth. Methods. We have performed detailed clinical, histopathologic, and immunologic investigations in six patients with DCL. Biopsies were taken from the nodules, processed, and examined for determination of the macrophagic pattern present, based on the intensity of vacuolation and the frequency of vacuolated cells, the parasite index, and the presence of eosinophils. Immunologically, patients were evaluated by their response to intradermal skin test to PPD or leishmania antigen, determination of antileishmania antibodies by immunofluorescent assay, and lymphocyte proliferation assay. Results. There seemed to be a negative relation between nodules and skin ulcerations, whereas the highest number of parasites were observed in patients with the greatest number of vacuolated macrophages. The delayed hypersensitivity skin test to leishmanial antigen was negative, and antileishmania IgG antibodies were positive in all patients. Conclusions. Although all cases fulfill the criteria for being classified as DCL, they present a wide spectrum. Three cases were clearly at the unresponsive pole, and three other cases belonged to the subpolar form of DCL, exhibiting varying weak signs of antiparasite responsiveness.engWileyLeishmaniose cutâneaLeishmaniaImunidadeEstudo clinicoMacrofagosHumanosCutaneous leishmaniasisLeishmaniasisImmunityClinical studyMacrophagesHumansPolar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32109/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBarral AM Polar and subpolar...1995.pdfBarral AM Polar and 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| dc.title.pt_BR.fl_str_mv |
Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects |
| title |
Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects |
| spellingShingle |
Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects Barral, Aldina Maria Prado Leishmaniose cutânea Leishmania Imunidade Estudo clinico Macrofagos Humanos Cutaneous leishmaniasis Leishmaniasis Immunity Clinical study Macrophages Humans |
| title_short |
Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects |
| title_full |
Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects |
| title_fullStr |
Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects |
| title_full_unstemmed |
Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects |
| title_sort |
Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathological aspects |
| author |
Barral, Aldina Maria Prado |
| author_facet |
Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Bittencourt, Achilea Candida Lisboa Barral Netto, Manoel Carvalho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Costa, Jackson Mauricio Lopes Bittencourt, Achilea Candida Lisboa Barral Netto, Manoel Carvalho, Edgar Marcelino de |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Barral, Aldina Maria Prado Costa, Jackson Mauricio Lopes Bittencourt, Achilea Candida Lisboa Barral Netto, Manoel Carvalho, Edgar Marcelino de |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose cutânea Leishmania Imunidade Estudo clinico Macrofagos Humanos |
| topic |
Leishmaniose cutânea Leishmania Imunidade Estudo clinico Macrofagos Humanos Cutaneous leishmaniasis Leishmaniasis Immunity Clinical study Macrophages Humans |
| dc.subject.en.pt_BR.fl_str_mv |
Cutaneous leishmaniasis Leishmaniasis Immunity Clinical study Macrophages Humans |
| description |
Manoel Barral Neto; Barral, Aldina Maria Prado. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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1995 |
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1995 |
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2019-03-15T14:19:02Z |
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2019-03-15T14:19:02Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BARRAL, A.M. P. et al. Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathologic aspects. International Journal of Dermatology, v. 34, n. 7, p. 474-479, 1995. |
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https://www.arca.fiocruz.br/handle/icict/32109 |
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0011-9059 |
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BARRAL, A.M. P. et al. Polar and subpolar diffuse Cutaneous Leishmaniasis in Brazil: clinical and immunopathologic aspects. International Journal of Dermatology, v. 34, n. 7, p. 474-479, 1995. 0011-9059 |
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Wiley |
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Wiley |
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