Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains

Detalhes bibliográficos
Autor(a) principal: Araújo-Neto, José B. de
Data de Publicação: 2021
Outros Autores: Silva, Maria M. C. da, Tintino, Cícera D. de M. Oliveira, Begnini, Iêda M., Rebelo, Ricardo A., Silva, Luiz E. da, Mireski, Sandro L., Nasato, Michele C., Krautler, Maria I. L., Ribeiro-Filho, Jaime, Siyadatpanah, Abolghasem, Wilairatana, Polrat, Coutinho, Henrique D. M., Tintino, Saulo R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51069
Resumo: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Fundação Cearense de Desenvolvimento Científico e Apoio ao Desenvolvimento Tecnológico (FUNCAP) e Financiadora de Estudos e Projetos-Brasil (FINEP).
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spelling Araújo-Neto, José B. deSilva, Maria M. C. daTintino, Cícera D. de M. OliveiraBegnini, Iêda M.Rebelo, Ricardo A.Silva, Luiz E. daMireski, Sandro L.Nasato, Michele C.Krautler, Maria I. L.Ribeiro-Filho, JaimeSiyadatpanah, AbolghasemWilairatana, PolratCoutinho, Henrique D. M.Tintino, Saulo R.2022-02-08T13:26:58Z2022-02-08T13:26:58Z2021Araújo-Neto, José B. de et al. Enhancement of antibiotic activity by 1,8-naphthyridine derivatives against multi-resistant bacterial strains. Molecules, v. 26, n. 23, p. 1-9, 2021.1420-3049https://www.arca.fiocruz.br/handle/icict/51069doi.org/10.3390/molecules26237400Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Fundação Cearense de Desenvolvimento Científico e Apoio ao Desenvolvimento Tecnológico (FUNCAP) e Financiadora de Estudos e Projetos-Brasil (FINEP).Universidade Regional do Cariri. Laboratório de Microbiologia e Biologia Molecular. Fortaleza, CE, Brasil.Universidade Regional do Cariri. Laboratório de Microbiologia e Biologia Molecular. Fortaleza, CE, Brasil.Universidade Regional do Cariri. Laboratório de Microbiologia e Biologia Molecular. Fortaleza, CE, Brasil.Universidade Regional de Blumenau. Departamento de Química. Blumenau, SC, Brasil.Universidade Regional de Blumenau. Departamento de Química. Blumenau, SC, Brasil.Universidade Federal do Paraná. Programa de Pós-Graduação em Desenvolvimento Territorial Sustentável – Setor Costeiro. Curitiba, PR, Brasil.Universidade Regional de Blumenau. Departamento de Química. Blumenau, SC, Brasil.Universidade Regional de Blumenau. Departamento de Química. Blumenau, SC, Brasil.Universidade Regional de Blumenau. Departamento de Química. Blumenau, SC, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Ferdows School of Paramedical and Health. Birjand University of Medical Sciences. Birjand, Iran / Infectious Diseases Research Center. Birjand University of Medical Sciences. Birjand, Iran.Department of Clinical Tropical Medicine. Faculty of Tropical Medicine. Mahidol University. Bangkok, Thailand.Universidade Regional do Cariri. Laboratório de Microbiologia e Biologia Molecular. Fortaleza, CE, Brasil.Universidade Regional do Cariri. Laboratório de Microbiologia e Biologia Molecular. Fortaleza, CE, Brasil.Abstract: The search for new antibacterial agents has become urgent due to the exponential growth of bacterial resistance to antibiotics. Nitrogen-containing heterocycles such as 1,8-naphthyridine derivatives have been shown to have excellent antimicrobial properties. Therefore, the purpose of this study was to evaluate the antibacterial and antibiotic-modulating activities of 1,8-naphthyridine derivatives against multi-resistant bacterial strains. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of the following compounds: 7-acetamido-1,8-naphthyridin-4(1H)-one and 3-trifluoromethyl-N-(5-chloro-1,8- aphthyridin-2-yl)-benzenesulfonamide. The antibioticmodulating activity was analyzed using subinhibitory concentrations (MIC/8) of these compounds in combination with norfloxacin, ofloxacin, and lomefloxacin. Multi-resistant strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were used in both tests. Although the compounds had no direct antibacterial activity (MIC 1.024 g/mL), they could decrease the MIC of these fluoroquinolones, indicating synergism was obtained from the association of the compounds. hese results suggest the existence of a structure–activity relationship in this group of compounds with regard to the modulation of antibiotic activity. Therefore, we conclude that 1,8-naphthyridine derivatives potentiate the activity of fluoroquinolone antibiotics against multi-resistant bacterial strains, and thereby interesting candidates for the development of drugs against bacterial infections caused by multidrug resistant strains.engMDPIFluoroquinolonasResistência bacterianaFluoroquinolonesBacterial resistanceEnhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51069/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAraújo-Neto, J.B.S. Enhancement....pdfAraújo-Neto, J.B.S. Enhancement....pdfapplication/pdf1182616https://www.arca.fiocruz.br/bitstream/icict/51069/2/Ara%c3%bajo-Neto%2c%20J.B.S.%20Enhancement....pdf383f9cdf1502b1b783cceadfad4b3789MD52icict/510692023-03-15 14:34:34.256oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
title Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
spellingShingle Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
Araújo-Neto, José B. de
Fluoroquinolonas
Resistência bacteriana
Fluoroquinolones
Bacterial resistance
title_short Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
title_full Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
title_fullStr Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
title_full_unstemmed Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
title_sort Enhancement of Antibiotic Activity by 1,8-Naphthyridine Derivatives against Multi-Resistant Bacterial Strains
author Araújo-Neto, José B. de
author_facet Araújo-Neto, José B. de
Silva, Maria M. C. da
Tintino, Cícera D. de M. Oliveira
Begnini, Iêda M.
Rebelo, Ricardo A.
Silva, Luiz E. da
Mireski, Sandro L.
Nasato, Michele C.
Krautler, Maria I. L.
Ribeiro-Filho, Jaime
Siyadatpanah, Abolghasem
Wilairatana, Polrat
Coutinho, Henrique D. M.
Tintino, Saulo R.
author_role author
author2 Silva, Maria M. C. da
Tintino, Cícera D. de M. Oliveira
Begnini, Iêda M.
Rebelo, Ricardo A.
Silva, Luiz E. da
Mireski, Sandro L.
Nasato, Michele C.
Krautler, Maria I. L.
Ribeiro-Filho, Jaime
Siyadatpanah, Abolghasem
Wilairatana, Polrat
Coutinho, Henrique D. M.
Tintino, Saulo R.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo-Neto, José B. de
Silva, Maria M. C. da
Tintino, Cícera D. de M. Oliveira
Begnini, Iêda M.
Rebelo, Ricardo A.
Silva, Luiz E. da
Mireski, Sandro L.
Nasato, Michele C.
Krautler, Maria I. L.
Ribeiro-Filho, Jaime
Siyadatpanah, Abolghasem
Wilairatana, Polrat
Coutinho, Henrique D. M.
Tintino, Saulo R.
dc.subject.other.pt_BR.fl_str_mv Fluoroquinolonas
Resistência bacteriana
topic Fluoroquinolonas
Resistência bacteriana
Fluoroquinolones
Bacterial resistance
dc.subject.en.pt_BR.fl_str_mv Fluoroquinolones
Bacterial resistance
description Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento do Pessoal de Nível Superior (CAPES), Fundação Cearense de Desenvolvimento Científico e Apoio ao Desenvolvimento Tecnológico (FUNCAP) e Financiadora de Estudos e Projetos-Brasil (FINEP).
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-02-08T13:26:58Z
dc.date.available.fl_str_mv 2022-02-08T13:26:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Araújo-Neto, José B. de et al. Enhancement of antibiotic activity by 1,8-naphthyridine derivatives against multi-resistant bacterial strains. Molecules, v. 26, n. 23, p. 1-9, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51069
dc.identifier.issn.pt_BR.fl_str_mv 1420-3049
dc.identifier.doi.none.fl_str_mv doi.org/10.3390/molecules26237400
identifier_str_mv Araújo-Neto, José B. de et al. Enhancement of antibiotic activity by 1,8-naphthyridine derivatives against multi-resistant bacterial strains. Molecules, v. 26, n. 23, p. 1-9, 2021.
1420-3049
doi.org/10.3390/molecules26237400
url https://www.arca.fiocruz.br/handle/icict/51069
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51069/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51069/2/Ara%c3%bajo-Neto%2c%20J.B.S.%20Enhancement....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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