Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil

Detalhes bibliográficos
Autor(a) principal: Assis, Tália Santana Machado de
Data de Publicação: 2012
Outros Autores: Rabello, Ana Lúcia Teles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7657
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brazil
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spelling Assis, Tália Santana Machado deRabello, Ana Lúcia Teles2014-05-28T14:06:57Z2014-05-28T14:06:57Z2012ASSIS, Talia Santana Machado de; RABELLO, Ana Lucia Teles; WERNECK, Guilherme Loureiro. Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil. Tropical Medicine and International Health. 2012, vol.17, pp. 1202-12071360-2276https://www.arca.fiocruz.br/handle/icict/765710.1111/j.1365-3156.2012.03064.xengBelgian Society of Tropical MedicineLatent class analysis of diagnostic tests for visceral leishmaniasis in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, BrazilUniversidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Departamento de Epidemiologia. Rio de Janeiro, BrazilObjective  To estimate the sensitivities and specificities of different diagnostic tests for visceral leishmaniasis (VL) using latent class analysis (LCA). Methods  This study was performed using data from a prospective study conducted in four Brazilian states from May 2004 to May 2007. Five diagnostic tests for VL were evaluated in 285 VL cases and 119 non-cases: microscopy, indirect fluorescence antibody test (IFAT), enzyme-linked immunosorbent assay using recombinant K39 antigen (rK39-ELISA), direct agglutination test (DAT) and the rK39 rapid test. Results  Microscopy showed sensitivity of 77.0% (CI: 71.5–81.5) and specificity of 99.0% (CI: 94.0–99.7). The IFAT and the DAT showed similar sensitivities, 88.3% (CI: 84.0–92.0) and 88.5% (CI: 84.1–92.0), respectively, but the DAT had a higher specificity (95.4%, CI: 89.2–98.1) than did the IFAT (83.0%, CI: 75.0–88.2). The rK39-ELISA and the rK39 rapid test showed sensitivities of 99.0% (CI: 96.3–99.6) and 94.0% (CI: 90.1–96.3), and specificities of 82.5% (CI: 75.0–88.3) and 100% (CI: 97.0–100.0%), respectively. Conclusions  Considering the lack of an adequate reference standard, LCA proved to be a useful tool in validating diagnostic methods for VL. The DAT and the rK39 rapid test showed better performance. Thus, clinically suspected cases of VL in a Brazilian endemic area could be treated based on the positivity of one of these tests.visceral leishmaniasisdiagnosislatent class analysisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLatent class analysis of diagnostic tests for visceral leishmaniasis in Brazil. Tropical Medicine and International Health.pdfLatent class analysis of diagnostic tests for visceral leishmaniasis in Brazil. 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dc.title.pt_BR.fl_str_mv Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil
title Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil
spellingShingle Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil
Assis, Tália Santana Machado de
visceral leishmaniasis
diagnosis
latent class analysis
title_short Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil
title_full Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil
title_fullStr Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil
title_full_unstemmed Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil
title_sort Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil
author Assis, Tália Santana Machado de
author_facet Assis, Tália Santana Machado de
Rabello, Ana Lúcia Teles
author_role author
author2 Rabello, Ana Lúcia Teles
author2_role author
dc.contributor.author.fl_str_mv Assis, Tália Santana Machado de
Rabello, Ana Lúcia Teles
dc.subject.en.pt_BR.fl_str_mv visceral leishmaniasis
diagnosis
latent class analysis
topic visceral leishmaniasis
diagnosis
latent class analysis
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-05-28T14:06:57Z
dc.date.available.fl_str_mv 2014-05-28T14:06:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ASSIS, Talia Santana Machado de; RABELLO, Ana Lucia Teles; WERNECK, Guilherme Loureiro. Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil. Tropical Medicine and International Health. 2012, vol.17, pp. 1202-1207
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7657
dc.identifier.issn.none.fl_str_mv 1360-2276
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-3156.2012.03064.x
identifier_str_mv ASSIS, Talia Santana Machado de; RABELLO, Ana Lucia Teles; WERNECK, Guilherme Loureiro. Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil. Tropical Medicine and International Health. 2012, vol.17, pp. 1202-1207
1360-2276
10.1111/j.1365-3156.2012.03064.x
url https://www.arca.fiocruz.br/handle/icict/7657
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Belgian Society of Tropical Medicine
publisher.none.fl_str_mv Belgian Society of Tropical Medicine
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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