Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria

Detalhes bibliográficos
Autor(a) principal: Borba, Joyce Villa Verde Bastos
Data de Publicação: 2022
Outros Autores: Silva, Arthur de Carvalho e, Nascimento, Marília Nunes do, Ferreira, Letícia Tiburcio, Rimoldi, Aline, Starling, Luísa, Ramos, Pablo Ivan Pereira, Costa, Fabio Trindade Maranhão, Andrade, Carolina Horta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55049
Resumo: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Fundação de Amparo à Pesquisa do Estado de Goiás (FAPEG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
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spelling Borba, Joyce Villa Verde BastosSilva, Arthur de Carvalho eNascimento, Marília Nunes doFerreira, Letícia TiburcioRimoldi, AlineStarling, LuísaRamos, Pablo Ivan PereiraCosta, Fabio Trindade MaranhãoAndrade, Carolina Horta2022-10-07T14:43:24Z2022-10-07T14:43:24Z2022BASTOS, Borba, Joyce Villa Verde et al. Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria. Computational and Structural Biotechnology Journal, v. 20, p. 1-10, 2022.2001-0370https://www.arca.fiocruz.br/handle/icict/5504910.1016/j.csbj.2022.07.003Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Fundação de Amparo à Pesquisa do Estado de Goiás (FAPEG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil / Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil / Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Malaria is a tropical disease caused by Plasmodium spp. and transmitted by the bite of infected Anopheles mosquitoes. Protein kinases (PKs) play key roles in the life cycle of the etiological agent of malaria, turning these proteins attractive targets for antimalarial drug discovery campaigns. As part of an effort to understand parasite signaling functions, we report the results of a bioinformatics pipeline analysis of PKs of eight Plasmodium species. To date, no P. malariae and P. ovale kinome assemble has been conducted. We classified, curated and annotated predicted kinases to update P. falciparum, P. vivax, P. yoelii, P. berghei, P. chabaudi, and P. knowlesi kinomes published to date, as well as report for the first time the kinomes of P. malariae and P. ovale. Overall, from 76 to 97 PKs were identified among all Plasmodium spp. kinomes. Most of the kinases were assigned to seven of nine major kinase groups: AGC, CAMK, CMGC, CK1, STE, TKL, OTHER; and the Plasmodium-specific group FIKK. About 30% of kinases have been deeply classified into group, family and subfamily levels and only about 10% remained unclassified. Furthermore, updating and comparing the kinomes of P. vivax and P. falciparum allowed for the prioritization and selection of kinases as potential drug targets that could be explored for discovering new drugs against malaria. This integrated approach resulted in the selection of 37 protein kinases as potential targets and the identification of investigational compounds with moderate in vitro activity against asexual P. falciparum (3D7 and Dd2 strains) stages that could serve as starting points for the search of potent antimalarial leads in the future.engElsevierPlasmodiumMalariaDrug discoveryPlasmodiumProteína quinaseMaláriaKinomePriorização de destinoDescoberta de drogasPlasmodiumProtein kinaseMalariaKinomeTarget prioritizationDrug discoveryPlasmodiumMaláriaDescoberta de drogasUpdate and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBorba, Joyce - Update and elucidation of Plasmodium kinomes.pdfBorba, Joyce - Update and elucidation of Plasmodium kinomes.pdfapplication/pdf1665257https://www.arca.fiocruz.br/bitstream/icict/55049/2/Borba%2c%20Joyce%20-%20Update%20and%20elucidation%20of%20Plasmodium%20kinomes.pdf481627cad66ea2b70daf0c909db99d5cMD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
title Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
spellingShingle Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
Borba, Joyce Villa Verde Bastos
Plasmodium
Malaria
Drug discovery
Plasmodium
Proteína quinase
Malária
Kinome
Priorização de destino
Descoberta de drogas
Plasmodium
Protein kinase
Malaria
Kinome
Target prioritization
Drug discovery
Plasmodium
Malária
Descoberta de drogas
title_short Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
title_full Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
title_fullStr Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
title_full_unstemmed Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
title_sort Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
author Borba, Joyce Villa Verde Bastos
author_facet Borba, Joyce Villa Verde Bastos
Silva, Arthur de Carvalho e
Nascimento, Marília Nunes do
Ferreira, Letícia Tiburcio
Rimoldi, Aline
Starling, Luísa
Ramos, Pablo Ivan Pereira
Costa, Fabio Trindade Maranhão
Andrade, Carolina Horta
author_role author
author2 Silva, Arthur de Carvalho e
Nascimento, Marília Nunes do
Ferreira, Letícia Tiburcio
Rimoldi, Aline
Starling, Luísa
Ramos, Pablo Ivan Pereira
Costa, Fabio Trindade Maranhão
Andrade, Carolina Horta
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Borba, Joyce Villa Verde Bastos
Silva, Arthur de Carvalho e
Nascimento, Marília Nunes do
Ferreira, Letícia Tiburcio
Rimoldi, Aline
Starling, Luísa
Ramos, Pablo Ivan Pereira
Costa, Fabio Trindade Maranhão
Andrade, Carolina Horta
dc.subject.mesh.en_US.fl_str_mv Plasmodium
Malaria
Drug discovery
topic Plasmodium
Malaria
Drug discovery
Plasmodium
Proteína quinase
Malária
Kinome
Priorização de destino
Descoberta de drogas
Plasmodium
Protein kinase
Malaria
Kinome
Target prioritization
Drug discovery
Plasmodium
Malária
Descoberta de drogas
dc.subject.other.en_US.fl_str_mv Plasmodium
Proteína quinase
Malária
Kinome
Priorização de destino
Descoberta de drogas
dc.subject.en.en_US.fl_str_mv Plasmodium
Protein kinase
Malaria
Kinome
Target prioritization
Drug discovery
dc.subject.decs.en_US.fl_str_mv Plasmodium
Malária
Descoberta de drogas
description Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Fundação de Amparo à Pesquisa do Estado de Goiás (FAPEG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-07T14:43:24Z
dc.date.available.fl_str_mv 2022-10-07T14:43:24Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BASTOS, Borba, Joyce Villa Verde et al. Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria. Computational and Structural Biotechnology Journal, v. 20, p. 1-10, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55049
dc.identifier.issn.en_US.fl_str_mv 2001-0370
dc.identifier.doi.none.fl_str_mv 10.1016/j.csbj.2022.07.003
identifier_str_mv BASTOS, Borba, Joyce Villa Verde et al. Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria. Computational and Structural Biotechnology Journal, v. 20, p. 1-10, 2022.
2001-0370
10.1016/j.csbj.2022.07.003
url https://www.arca.fiocruz.br/handle/icict/55049
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55049/2/Borba%2c%20Joyce%20-%20Update%20and%20elucidation%20of%20Plasmodium%20kinomes.pdf
https://www.arca.fiocruz.br/bitstream/icict/55049/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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