Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/55049 |
Resumo: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Fundação de Amparo à Pesquisa do Estado de Goiás (FAPEG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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Borba, Joyce Villa Verde BastosSilva, Arthur de Carvalho eNascimento, Marília Nunes doFerreira, Letícia TiburcioRimoldi, AlineStarling, LuísaRamos, Pablo Ivan PereiraCosta, Fabio Trindade MaranhãoAndrade, Carolina Horta2022-10-07T14:43:24Z2022-10-07T14:43:24Z2022BASTOS, Borba, Joyce Villa Verde et al. Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria. Computational and Structural Biotechnology Journal, v. 20, p. 1-10, 2022.2001-0370https://www.arca.fiocruz.br/handle/icict/5504910.1016/j.csbj.2022.07.003Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Fundação de Amparo à Pesquisa do Estado de Goiás (FAPEG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil / Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Fármacos. Goiânia, GO, Brasil / Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Evolução Genética, Microbiologia e Imunologia. Laboratório de Doenças Tropicais – Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Malaria is a tropical disease caused by Plasmodium spp. and transmitted by the bite of infected Anopheles mosquitoes. Protein kinases (PKs) play key roles in the life cycle of the etiological agent of malaria, turning these proteins attractive targets for antimalarial drug discovery campaigns. As part of an effort to understand parasite signaling functions, we report the results of a bioinformatics pipeline analysis of PKs of eight Plasmodium species. To date, no P. malariae and P. ovale kinome assemble has been conducted. We classified, curated and annotated predicted kinases to update P. falciparum, P. vivax, P. yoelii, P. berghei, P. chabaudi, and P. knowlesi kinomes published to date, as well as report for the first time the kinomes of P. malariae and P. ovale. Overall, from 76 to 97 PKs were identified among all Plasmodium spp. kinomes. Most of the kinases were assigned to seven of nine major kinase groups: AGC, CAMK, CMGC, CK1, STE, TKL, OTHER; and the Plasmodium-specific group FIKK. About 30% of kinases have been deeply classified into group, family and subfamily levels and only about 10% remained unclassified. Furthermore, updating and comparing the kinomes of P. vivax and P. falciparum allowed for the prioritization and selection of kinases as potential drug targets that could be explored for discovering new drugs against malaria. This integrated approach resulted in the selection of 37 protein kinases as potential targets and the identification of investigational compounds with moderate in vitro activity against asexual P. falciparum (3D7 and Dd2 strains) stages that could serve as starting points for the search of potent antimalarial leads in the future.engElsevierPlasmodiumMalariaDrug discoveryPlasmodiumProteína quinaseMaláriaKinomePriorização de destinoDescoberta de drogasPlasmodiumProtein kinaseMalariaKinomeTarget prioritizationDrug discoveryPlasmodiumMaláriaDescoberta de drogasUpdate and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBorba, Joyce - Update and elucidation of Plasmodium kinomes.pdfBorba, Joyce - Update and elucidation of Plasmodium kinomes.pdfapplication/pdf1665257https://www.arca.fiocruz.br/bitstream/icict/55049/2/Borba%2c%20Joyce%20-%20Update%20and%20elucidation%20of%20Plasmodium%20kinomes.pdf481627cad66ea2b70daf0c909db99d5cMD52LICENSElicense.txtlicense.txttext/plain; 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| dc.title.en_US.fl_str_mv |
Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria |
| title |
Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria |
| spellingShingle |
Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria Borba, Joyce Villa Verde Bastos Plasmodium Malaria Drug discovery Plasmodium Proteína quinase Malária Kinome Priorização de destino Descoberta de drogas Plasmodium Protein kinase Malaria Kinome Target prioritization Drug discovery Plasmodium Malária Descoberta de drogas |
| title_short |
Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria |
| title_full |
Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria |
| title_fullStr |
Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria |
| title_full_unstemmed |
Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria |
| title_sort |
Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria |
| author |
Borba, Joyce Villa Verde Bastos |
| author_facet |
Borba, Joyce Villa Verde Bastos Silva, Arthur de Carvalho e Nascimento, Marília Nunes do Ferreira, Letícia Tiburcio Rimoldi, Aline Starling, Luísa Ramos, Pablo Ivan Pereira Costa, Fabio Trindade Maranhão Andrade, Carolina Horta |
| author_role |
author |
| author2 |
Silva, Arthur de Carvalho e Nascimento, Marília Nunes do Ferreira, Letícia Tiburcio Rimoldi, Aline Starling, Luísa Ramos, Pablo Ivan Pereira Costa, Fabio Trindade Maranhão Andrade, Carolina Horta |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Borba, Joyce Villa Verde Bastos Silva, Arthur de Carvalho e Nascimento, Marília Nunes do Ferreira, Letícia Tiburcio Rimoldi, Aline Starling, Luísa Ramos, Pablo Ivan Pereira Costa, Fabio Trindade Maranhão Andrade, Carolina Horta |
| dc.subject.mesh.en_US.fl_str_mv |
Plasmodium Malaria Drug discovery |
| topic |
Plasmodium Malaria Drug discovery Plasmodium Proteína quinase Malária Kinome Priorização de destino Descoberta de drogas Plasmodium Protein kinase Malaria Kinome Target prioritization Drug discovery Plasmodium Malária Descoberta de drogas |
| dc.subject.other.en_US.fl_str_mv |
Plasmodium Proteína quinase Malária Kinome Priorização de destino Descoberta de drogas |
| dc.subject.en.en_US.fl_str_mv |
Plasmodium Protein kinase Malaria Kinome Target prioritization Drug discovery |
| dc.subject.decs.en_US.fl_str_mv |
Plasmodium Malária Descoberta de drogas |
| description |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Fundação de Amparo à Pesquisa do Estado de Goiás (FAPEG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). |
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2022 |
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2022-10-07T14:43:24Z |
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2022-10-07T14:43:24Z |
| dc.date.issued.fl_str_mv |
2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
BASTOS, Borba, Joyce Villa Verde et al. Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria. Computational and Structural Biotechnology Journal, v. 20, p. 1-10, 2022. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/55049 |
| dc.identifier.issn.en_US.fl_str_mv |
2001-0370 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.csbj.2022.07.003 |
| identifier_str_mv |
BASTOS, Borba, Joyce Villa Verde et al. Update and elucidation of plasmodium kinomes: prioritization of kinases as potential drug targets for malaria. Computational and Structural Biotechnology Journal, v. 20, p. 1-10, 2022. 2001-0370 10.1016/j.csbj.2022.07.003 |
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Elsevier |
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Elsevier |
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