Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7806 |
Resumo: | Hospital Aeroporto. Lauro de Freitas, BA, Brasil |
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Pereira Filho, José do EgyptoAmorim, Daniele Meneses deSweet, Glória Maria MaranhãoFreitas, Luiz Antonio Rodrigues deAthanazio, Paulo Roberto FontesAthanazio, Daniel Abensur2014-06-09T17:10:16Z2014-06-09T17:10:16Z2012PEREIRA FILHO, J. do E. et al. Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining. Annals of Diagnostic Pathology, v. 16, p. 397–401, 2012.1092-9134https://www.arca.fiocruz.br/handle/icict/780610.1016/j.anndiagpath.2011.03.004engElsevier IncRenal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lininginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Aeroporto. Lauro de Freitas, BA, BrasilFederal University of Bahia. Salvador, BA, BrasilImagepat Anatomic Pathology Laboratory. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, Brasil / Imagepat Anatomic Pathology Laboratory. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, Brasil / Imagepat Anatomic Pathology Laboratory. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, BrasilRenal angiomyolipoma (AML) may present as rare variants such as epithelioid and AML with epithelial cysts posing difficulties for the diagnosis to the surgical pathologist. We report a case of a 46-year-old male patient presenting a 5-cm solid tumor in the lower pole of the left kidney, with cystic changes at cut surface. The tumor exhibited 95% of epithelioid cells with atypical nuclei. A small focus of typical AML was observed. The immunoprofile of tumor cells was classical of AML including expression of melanocytic markers such as HMB45 and Melan A. We report the immunohistochemical study of the cystic component in an epithelioid AML. In contrast to the immunoreactivity reported in typical AML, the present case shows obvious expression of melanocytic markers in the cystic epithelial lining. This is strong evidence that these cysts are neoplastic and derived from AML, rather than entrapped native collecting duct epithelium. © 2012 Elsevier Inc. All rights reserved.Angiomyolipoma;KidneyPerivascular epithelioid cell neoplasmsImmunohistochemistryKidney neoplasmsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPereira Filho JE Renal epithelioid....pdfPereira Filho JE Renal epithelioid....pdfapplication/pdf1603063https://www.arca.fiocruz.br/bitstream/icict/7806/1/Pereira%20Filho%20JE%20Renal%20epithelioid....pdf83e96fd86b2a8118f33510eb6447b61cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7806/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTPereira Filho JE Renal epithelioid....pdf.txtPereira Filho JE Renal epithelioid....pdf.txtExtracted texttext/plain16644https://www.arca.fiocruz.br/bitstream/icict/7806/5/Pereira%20Filho%20JE%20Renal%20epithelioid....pdf.txt508ac71c3655368d21ad1fe6d5233437MD55THUMBNAILPereira Filho JE Renal epithelioid....pdf.jpgPereira Filho JE Renal epithelioid....pdf.jpgGenerated Thumbnailimage/jpeg2288https://www.arca.fiocruz.br/bitstream/icict/7806/4/Pereira%20Filho%20JE%20Renal%20epithelioid....pdf.jpga9fac86606477e7ed3c5744ebe260c9aMD54icict/78062023-03-15 14:33:19.46oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining |
| title |
Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining |
| spellingShingle |
Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining Pereira Filho, José do Egypto Angiomyolipoma; Kidney Perivascular epithelioid cell neoplasms Immunohistochemistry Kidney neoplasms |
| title_short |
Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining |
| title_full |
Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining |
| title_fullStr |
Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining |
| title_full_unstemmed |
Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining |
| title_sort |
Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining |
| author |
Pereira Filho, José do Egypto |
| author_facet |
Pereira Filho, José do Egypto Amorim, Daniele Meneses de Sweet, Glória Maria Maranhão Freitas, Luiz Antonio Rodrigues de Athanazio, Paulo Roberto Fontes Athanazio, Daniel Abensur |
| author_role |
author |
| author2 |
Amorim, Daniele Meneses de Sweet, Glória Maria Maranhão Freitas, Luiz Antonio Rodrigues de Athanazio, Paulo Roberto Fontes Athanazio, Daniel Abensur |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Pereira Filho, José do Egypto Amorim, Daniele Meneses de Sweet, Glória Maria Maranhão Freitas, Luiz Antonio Rodrigues de Athanazio, Paulo Roberto Fontes Athanazio, Daniel Abensur |
| dc.subject.en.pt_BR.fl_str_mv |
Angiomyolipoma; Kidney Perivascular epithelioid cell neoplasms Immunohistochemistry Kidney neoplasms |
| topic |
Angiomyolipoma; Kidney Perivascular epithelioid cell neoplasms Immunohistochemistry Kidney neoplasms |
| description |
Hospital Aeroporto. Lauro de Freitas, BA, Brasil |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
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2014-06-09T17:10:16Z |
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2014-06-09T17:10:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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PEREIRA FILHO, J. do E. et al. Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining. Annals of Diagnostic Pathology, v. 16, p. 397–401, 2012. |
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https://www.arca.fiocruz.br/handle/icict/7806 |
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1092-9134 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.anndiagpath.2011.03.004 |
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PEREIRA FILHO, J. do E. et al. Renal epithelioid angiomyolipoma with epithelial cysts: demonstration of melan A and HMB45 positivity in the cystic epithelial lining. Annals of Diagnostic Pathology, v. 16, p. 397–401, 2012. 1092-9134 10.1016/j.anndiagpath.2011.03.004 |
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Elsevier Inc |
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Elsevier Inc |
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