Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25695 |
Resumo: | Bahia State Agency for Research Funding (FAPESB) (grant no. PNX 0019/2009). |
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Vasconcellos, Ângela Gomes deClarêncio, JorgeAndrade, Daniela RodriguesCardoso, Maria Regina AlvesBarral, Aldina Maria PradoCarvalho, Cristiana Maria Costa Nascimento2018-04-09T19:00:17Z2018-04-09T19:00:17Z2017VASCONCELLOS, A. G. et al. Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia. Cytokine, 2017.1043-4666https://www.arca.fiocruz.br/handle/icict/2569510.1016/j.cyto.2017.11.005Bahia State Agency for Research Funding (FAPESB) (grant no. PNX 0019/2009).Federal University of Bahia School of Medicine. Postgraduate in Health Sciences. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSão Paulo University School of Public Health. São Paulo, SP, BrazilFederal University of Bahia School of Medicine. Postgraduate in Health Sciences. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia School of Medicine. Postgraduate in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia School of Medicine. Department of Pediatrics. Salvador, BA, BrazilCommunity-acquired pneumonia (CAP) is the main cause of death in children under-5 years worldwide and Streptococcus pneumoniae is the most common bacterial agent. However, it is difficult to identify pneumococcal infection among children with CAP. We aimed to assess association between any cytokine/chemokine and pneumococcal infection in childhood CAP. Furthermore, we evaluated the diagnostic value of cytokine/chemokine for pneumococcal infection. This prospective study was conducted at an Emergency Room, in Salvador, Brazil. Children <5-years-old hospitalized with CAP in a 21-month period were evaluated. On admission, clinical and radiological data were collected along with biological samples to investigate 20 etiological agents and determine serum cytokines (interleukin (IL)-8, IL-6, IL-10, IL-1β, IL-12, TNF-α, IL-2, IL-4, IL-5, γ-interferon), and chemokines (CCL2, CCL5, CXCL9, CXCL10) concentration. From 166 patients with etiology detected, pneumococcal infection was detected in 38 (22.9%) cases among which the median IL-6(pg/ml) was 31.2 (IQR: 12.4-54.1). The other 128 cases had other causative agents detected (Haemophilus influenzae, Moraxella catarrhalis, atypical bacteria and viruses) with the median IL-6 concentration being 9.0 (IQR: 4.1-22.0; p < 0.001). The area under the ROC curve for IL-6 to predict pneumococcal CAP was 0.74 (95%CI: 0.65-0.83; p < 0.001). By multivariate analysis, with pneumococcal CAP as dependent variable, IL-6 was an independent predictor for pneumococcal infection (OR = 5.56; 95%CI: 2.42-12.75, cut-off point = 12.5 pg/ml; p = 0.0001). The negative predictive value of IL-6 under 12.5 pg/ml for pneumococcal infection was 90% (95%CI: 82-95%). Independently significant difference was not found for any other cytokines/chemokines. Serum IL-6 concentration on admission is independently associated with pneumococcal infection among children under-5 years hospitalized with CAP.engElsevierInfecção respiratória agudaCriançaInfecção do trato respiratório inferiorDoença pulmonarInfecção pneumocócicaAcute respiratory infectionChildLower respiratory tract infectionLung diseasePneumococcal infectionSystemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumoniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25695/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVasconcellos AG Systemic cytokines and....pdfVasconcellos AG Systemic cytokines 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| dc.title.pt_BR.fl_str_mv |
Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia |
| title |
Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia |
| spellingShingle |
Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia Vasconcellos, Ângela Gomes de Infecção respiratória aguda Criança Infecção do trato respiratório inferior Doença pulmonar Infecção pneumocócica Acute respiratory infection Child Lower respiratory tract infection Lung disease Pneumococcal infection |
| title_short |
Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia |
| title_full |
Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia |
| title_fullStr |
Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia |
| title_full_unstemmed |
Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia |
| title_sort |
Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia |
| author |
Vasconcellos, Ângela Gomes de |
| author_facet |
Vasconcellos, Ângela Gomes de Clarêncio, Jorge Andrade, Daniela Rodrigues Cardoso, Maria Regina Alves Barral, Aldina Maria Prado Carvalho, Cristiana Maria Costa Nascimento |
| author_role |
author |
| author2 |
Clarêncio, Jorge Andrade, Daniela Rodrigues Cardoso, Maria Regina Alves Barral, Aldina Maria Prado Carvalho, Cristiana Maria Costa Nascimento |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Vasconcellos, Ângela Gomes de Clarêncio, Jorge Andrade, Daniela Rodrigues Cardoso, Maria Regina Alves Barral, Aldina Maria Prado Carvalho, Cristiana Maria Costa Nascimento |
| dc.subject.other.pt_BR.fl_str_mv |
Infecção respiratória aguda Criança Infecção do trato respiratório inferior Doença pulmonar Infecção pneumocócica |
| topic |
Infecção respiratória aguda Criança Infecção do trato respiratório inferior Doença pulmonar Infecção pneumocócica Acute respiratory infection Child Lower respiratory tract infection Lung disease Pneumococcal infection |
| dc.subject.en.pt_BR.fl_str_mv |
Acute respiratory infection Child Lower respiratory tract infection Lung disease Pneumococcal infection |
| description |
Bahia State Agency for Research Funding (FAPESB) (grant no. PNX 0019/2009). |
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2017 |
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2017 |
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2018-04-09T19:00:17Z |
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2018-04-09T19:00:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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VASCONCELLOS, A. G. et al. Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia. Cytokine, 2017. |
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https://www.arca.fiocruz.br/handle/icict/25695 |
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1043-4666 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.cyto.2017.11.005 |
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VASCONCELLOS, A. G. et al. Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia. Cytokine, 2017. 1043-4666 10.1016/j.cyto.2017.11.005 |
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Elsevier |
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Elsevier |
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