Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40341 |
Resumo: | Artigo encontra-se disponível em acesso aberto no site do Editor. |
| id |
CRUZ_f346ac48eb78f1207a0fe349d758ee5b |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/40341 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Carvalho, Eduardo C NascimentoVasconcellos, Ângela GomesClarêncio, JorgeAndrade, DanielaBarral, Aldina Maria PradoBarral Netto, ManoelCarvalho, Cristiana Maria Nascimento2020-03-16T12:33:42Z2020-03-16T12:33:42Z2020CARVALHO, Eduardo C Nascimento et al. Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies. Pediatric Pulmonology, v. 55, p. 169–176, 2020.8755-6863https://www.arca.fiocruz.br/handle/icict/4034110.1002/ppul.24533Artigo encontra-se disponível em acesso aberto no site do Editor.Bahia State Agency for Research Funding (FAPESB; grant no. PNX 0019/2009). AB, MB‐N, and CMN‐C are senior investigators at the Brazilian Council for Scientific and Technological Development (CNPq). ECN‐C was recipient of the CNPq fellowship (163661/2018‐9).Bahiana Foundation for Science Development. Bahiana School of Medicine and Public Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil.Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brazil / Federal University of Bahia School of Medicine. Department of Pediatrics. Salvador, BA, Brazil.To compare the systemic cytokines/chemokines levels over time during the evolution of children hospitalized with community-acquired pneumonia (CAP) with and without pneumococcal infection. Methods: Children less than 5‐years‐old hospitalized with CAP were prospectively investigated in Salvador, Brazil. Clinical data and biological samples were collected to investigate 20 etiological agents and to determine serum cytokines/chemokines levels on admission and 2 to 4 weeks later. Cases with pneumococcal infection received this diagnosis irrespective of also having other etiologies. Results: A total of 277 patients were enrolled, however, serum sample was unavailable for cytokine measurement upon admission (n = 61) or upon follow‐up visit (n = 36), etiology was undetected (n = 50) and one patient did not attend the follow‐up visit. Therefore, this study group comprised of 129 cases with established etiology. The median (interquartile range) age and sampling interval was 18 (9‐27) months and 18 (16‐21) days, respectively. Established etiology was viral (52.0%), viral‐bacterial (30.2%), and bacterial (17.8%). Pneumococcal infection was found in 31 (24.0%) patients. Overall, median interleukin‐6 (IL‐6; 10.6 [4.7‐30.6] vs 21.0 [20.2‐21.7]; P = .03), IL‐10 (3.5 [3.1‐4.5] vs 20.1 [19.8‐20.4]; P < .001), and CCL2 (19.3 [12.4‐23.2] vs 94.0 [67.2‐117.8]; P < .001) were significantly higher in convalescent serum samples, whereas median CXCL10 (83.6 [36.4‐182.9] vs 14.6 [0‐116.6]; P < .001) was lower. Acute vs convalescent levels evolution of IL‐10, CCL2, and CXCL10 did not differ among patients with or without pneumococcal infection. However, IL‐6 decreased (27.8 [12.3‐48.6] vs 20.8 [20.2‐22.6]; P = .1) in patients with pneumococcal infection and increased (9.0 [4.2‐22.6] vs 21.0 [20.2‐21.7]; P = .001) in patients without it. Conclusion: The marked increase of IL‐6 serum levels during the acute phase makes it a potential biomarker of pneumococcal infection among children with CAP.engWileyInfecção respiratória aguda,criança,Infecção do trato respiratório inferiorDoença pulmonarInfecção pneumocócicaAcute respiratory infectionChildLower respiratory tract infectionLung diseasePneumococcal infectionEvolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40341/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNascimento, C.E. Evolution....pdfNascimento, C.E. Evolution....pdfapplication/pdf515433https://www.arca.fiocruz.br/bitstream/icict/40341/2/Nascimento%2c%20C.E.%20Evolution....pdf74041367fbba9feab0c929e6d729c986MD52TEXTNascimento, C.E. Evolution....pdf.txtNascimento, C.E. Evolution....pdf.txtExtracted texttext/plain39301https://www.arca.fiocruz.br/bitstream/icict/40341/3/Nascimento%2c%20C.E.%20Evolution....pdf.txt0fb55fc9c8804ec8a24fe0b806b6fba3MD53icict/403412023-03-15 14:34:26.171oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies |
| title |
Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies |
| spellingShingle |
Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies Carvalho, Eduardo C Nascimento Infecção respiratória aguda, criança, Infecção do trato respiratório inferior Doença pulmonar Infecção pneumocócica Acute respiratory infection Child Lower respiratory tract infection Lung disease Pneumococcal infection |
| title_short |
Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies |
| title_full |
Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies |
| title_fullStr |
Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies |
| title_full_unstemmed |
Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies |
| title_sort |
Evolution of cytokines/chemokines in cases with community-acquired pneumonia and distinct etiologies |
| author |
Carvalho, Eduardo C Nascimento |
| author_facet |
Carvalho, Eduardo C Nascimento Vasconcellos, Ângela Gomes Clarêncio, Jorge Andrade, Daniela Barral, Aldina Maria Prado Barral Netto, Manoel Carvalho, Cristiana Maria Nascimento |
| author_role |
author |
| author2 |
Vasconcellos, Ângela Gomes Clarêncio, Jorge Andrade, Daniela Barral, Aldina Maria Prado Barral Netto, Manoel Carvalho, Cristiana Maria Nascimento |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Eduardo C Nascimento Vasconcellos, Ângela Gomes Clarêncio, Jorge Andrade, Daniela Barral, Aldina Maria Prado Barral Netto, Manoel Carvalho, Cristiana Maria Nascimento |
| dc.subject.other.pt_BR.fl_str_mv |
Infecção respiratória aguda, criança, Infecção do trato respiratório inferior Doença pulmonar Infecção pneumocócica |
| topic |
Infecção respiratória aguda, criança, Infecção do trato respiratório inferior Doença pulmonar Infecção pneumocócica Acute respiratory infection Child Lower respiratory tract infection Lung disease Pneumococcal infection |
| dc.subject.en.pt_BR.fl_str_mv |
Acute respiratory infection Child Lower respiratory tract infection Lung disease Pneumococcal infection |
| description |
Artigo encontra-se disponível em acesso aberto no site do Editor. |
| publishDate |
2020 |
| dc.date.accessioned.fl_str_mv |
2020-03-16T12:33:42Z |
| dc.date.available.fl_str_mv |
2020-03-16T12:33:42Z |
| dc.date.issued.fl_str_mv |
2020 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
CARVALHO, Eduardo C Nascimento et al. Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies. Pediatric Pulmonology, v. 55, p. 169–176, 2020. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/40341 |
| dc.identifier.issn.pt_BR.fl_str_mv |
8755-6863 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/ppul.24533 |
| identifier_str_mv |
CARVALHO, Eduardo C Nascimento et al. Evolution of cytokines/chemokines in cases with community‐acquired pneumonia and distinct etiologies. Pediatric Pulmonology, v. 55, p. 169–176, 2020. 8755-6863 10.1002/ppul.24533 |
| url |
https://www.arca.fiocruz.br/handle/icict/40341 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/40341/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/40341/2/Nascimento%2c%20C.E.%20Evolution....pdf https://www.arca.fiocruz.br/bitstream/icict/40341/3/Nascimento%2c%20C.E.%20Evolution....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 74041367fbba9feab0c929e6d729c986 0fb55fc9c8804ec8a24fe0b806b6fba3 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009122127249408 |