Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2790 |
Resumo: | Agradecimentos a ATLQ e LAS que contribuíram igualmente para este trabalho, além de Elisabeth Deliège por sua assistência técnica. |
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Queiroz, Artur Trancoso Lopo deSantos, Luciane AmorimMoreau, Domingos RamonOliveira, Tulio deWatkins, David ICastro Filho, Bernardo GalvãoAlcantara, Luiz Carlos Júnior2011-08-08T19:15:22Z2011-08-08T19:15:22Z2007QUEIROZ, A. T. L. de. et al. Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil. The Brazilian Journal of Infectious Diseases, v.11, n.1, p.27-30, 2007.1413-8670https://www.arca.fiocruz.br/handle/icict/2790Agradecimentos a ATLQ e LAS que contribuíram igualmente para este trabalho, além de Elisabeth Deliège por sua assistência técnica.Pesquisa parcialmente financiada pela Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) e PN-DST/AIDS, Ministério da Saúde, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública / Fundação para o Desenvolvimento da Ciência. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilUniversity of Oxford. Department of Zoology. Oxford, United KingdomUniversity of Wisconsin Medical School. Department of Pathology. Madison, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública / Fundação para o Desenvolvimento da Ciência. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública / Fundação para o Desenvolvimento da Ciência. Salvador, BA, BrasilGenetic analysis of HIV-1 is essential to improve treatment strategies and select epitopes for vaccine programs. The objective of this study was to determine whether known CD4+ and CD8+ epitopes were present in Brazilian HIV-1 strains. We used previously described CD8+ and CD4+ epitopes from the Los Alamos laboratory to search for these epitopes in the Brazilian sequences using the HIVbase program and we compared the frequency results with the analyses using physical-chemical profile tools from Network Protein Sequence Analysis (NPSA), and the SYFPEITHI program. Furthermore, this analysis was carried out with the Prosite tool using the GeneDoc program and ds/dn analyses using the Synonymous Nonsynonymous Analysis Program (SNAP). The HIVbase epitope mapping demonstrated that 30 CD8+ and 6 CD4+ epitopes were present in the Brazilian sequences at a high frequency. Only two of these epitopes were heavily glycosylated. Interestingly, ds/dn analyses showed evidence of purifying selective pressure. These types of analyses could be useful for the assessment of possible vaccine efficiency in populations.engBrazilian Society of Infectious DiseasesHIV-1VacinaEpitopoGenes envHIV-1VaccineEpitopeenvBrasilLinfócitos T CD4-PositivosLinfócitos T CD8-PositivosEpitoposProdutos do Gene envInfecções por HIVHIV-1HumanosIdentification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALQueiroz_Santos_Moreau_etal.pdfQueiroz_Santos_Moreau_etal.pdfapplication/pdf396458https://www.arca.fiocruz.br/bitstream/icict/2790/1/Queiroz_Santos_Moreau_etal.pdf62c07b8e130826e538d5865d6211b15dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2790/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTQueiroz_Santos_Moreau_etal.pdf.txtQueiroz_Santos_Moreau_etal.pdf.txtExtracted texttext/plain18887https://www.arca.fiocruz.br/bitstream/icict/2790/5/Queiroz_Santos_Moreau_etal.pdf.txtf36bfb896de82193e05e22f4244b1131MD55THUMBNAILQueiroz_Santos_Moreau_etal.pdf.jpgQueiroz_Santos_Moreau_etal.pdf.jpgGenerated Thumbnailimage/jpeg2286https://www.arca.fiocruz.br/bitstream/icict/2790/4/Queiroz_Santos_Moreau_etal.pdf.jpg9d6276cd70064c4ff17584f8cef36a4dMD54icict/27902023-03-15 14:34:09.435oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil |
| title |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil |
| spellingShingle |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil Queiroz, Artur Trancoso Lopo de HIV-1 Vacina Epitopo Genes env HIV-1 Vaccine Epitope env Brasil Linfócitos T CD4-Positivos Linfócitos T CD8-Positivos Epitopos Produtos do Gene env Infecções por HIV HIV-1 Humanos |
| title_short |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil |
| title_full |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil |
| title_fullStr |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil |
| title_full_unstemmed |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil |
| title_sort |
Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil |
| author |
Queiroz, Artur Trancoso Lopo de |
| author_facet |
Queiroz, Artur Trancoso Lopo de Santos, Luciane Amorim Moreau, Domingos Ramon Oliveira, Tulio de Watkins, David I Castro Filho, Bernardo Galvão Alcantara, Luiz Carlos Júnior |
| author_role |
author |
| author2 |
Santos, Luciane Amorim Moreau, Domingos Ramon Oliveira, Tulio de Watkins, David I Castro Filho, Bernardo Galvão Alcantara, Luiz Carlos Júnior |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Queiroz, Artur Trancoso Lopo de Santos, Luciane Amorim Moreau, Domingos Ramon Oliveira, Tulio de Watkins, David I Castro Filho, Bernardo Galvão Alcantara, Luiz Carlos Júnior |
| dc.subject.other.pt_BR.fl_str_mv |
HIV-1 Vacina Epitopo Genes env |
| topic |
HIV-1 Vacina Epitopo Genes env HIV-1 Vaccine Epitope env Brasil Linfócitos T CD4-Positivos Linfócitos T CD8-Positivos Epitopos Produtos do Gene env Infecções por HIV HIV-1 Humanos |
| dc.subject.en.pt_BR.fl_str_mv |
HIV-1 Vaccine Epitope env |
| dc.subject.decs.pt_BR.fl_str_mv |
Brasil Linfócitos T CD4-Positivos Linfócitos T CD8-Positivos Epitopos Produtos do Gene env Infecções por HIV HIV-1 Humanos |
| description |
Agradecimentos a ATLQ e LAS que contribuíram igualmente para este trabalho, além de Elisabeth Deliège por sua assistência técnica. |
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2007 |
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2007 |
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2011-08-08T19:15:22Z |
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2011-08-08T19:15:22Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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QUEIROZ, A. T. L. de. et al. Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil. The Brazilian Journal of Infectious Diseases, v.11, n.1, p.27-30, 2007. |
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https://www.arca.fiocruz.br/handle/icict/2790 |
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1413-8670 |
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QUEIROZ, A. T. L. de. et al. Identification and characterization of previously described epitopes in HIV-1 subtypes B, C, F and BF in Brazil. The Brazilian Journal of Infectious Diseases, v.11, n.1, p.27-30, 2007. 1413-8670 |
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Brazilian Society of Infectious Diseases |
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Brazilian Society of Infectious Diseases |
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