Acute coronary syndrome: Relationship between genetic variants and TIMI risk

Detalhes bibliográficos
Autor(a) principal: Carvalho, Viviane do Carmo Vasconcelos de
Data de Publicação: 2018
Outros Autores: Silva, Lílian Caroliny Amorim, Araújo, Romário Martins, Silva Soares, Fábia Carla da, Bezerra, Maria José Ribeiro, Oliveira, Sávio Augusto Vieira de, Melo Silva, Alex José de, Montenegro, Sérgio Tavares, Werkhauser, Roberto Pereira, Silva, Carlos Gustavo Régis da, Gomes, Adriana Vieira, Morais, Clarice Neuenschwander Lins de, Montenegro, Silvia Maria Lucena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30734
Resumo: Proep APQ 1620 4.01/15.
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spelling Carvalho, Viviane do Carmo Vasconcelos deSilva, Lílian Caroliny AmorimAraújo, Romário MartinsSilva Soares, Fábia Carla daBezerra, Maria José RibeiroOliveira, Sávio Augusto Vieira deMelo Silva, Alex José deMontenegro, Sérgio TavaresWerkhauser, Roberto PereiraSilva, Carlos Gustavo Régis daGomes, Adriana VieiraMorais, Clarice Neuenschwander Lins deMontenegro, Silvia Maria Lucena2018-12-20T17:15:08Z2018-12-20T17:15:08Z2018CARVALHO, V. C. C. et al. Acute coronary syndrome: Relationship between genetic variants and TIMI risk. Cytokine, v. 110, p. 344–349, 2018.1043-4666https://www.arca.fiocruz.br/handle/icict/3073410.1016/j.cyto.2018.04.001Proep APQ 1620 4.01/15.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Real Hospital Português. Real Hospital do Coração. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasil.Universidade de Pernambuco. Faculdade de Ciências Médicas. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Virologia e Terapia Experimental. Departamento de Virologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunologia e Biologia Molecular. Departamento de Imunologia. Recife, PE, Brasil.Acute Coronary Syndrome (ACS) is a multifactorial disease, including the genetic factor, caused by coronary artery obstruction by atheroma. Some genetic variants have been described as risk factors for this disease. Its early diagnosis and stratification of risk of death by Thrombolysis in Myocardial Infarction (TIMI) are important. Therefore, we evaluated variants in the IL6R (c950-1722C>T), TNFa (c.-488G>A), LEPR (c.2673+1118C>T) and IL1b (c.-598T>C) genes in relation to TIMI risk, cytokine serum levels, and risk factors for ACS. We selected 200 patients with ACS, 50 without ACS from the Real Hospital Português, Recife - PE, and 295 blood donors at the Fundação de Hematologia e Hemoterapia de Pernambuco (Hemope). Variants were determined by DNA sequencing or enzymatic cleavage. Cytokine levels were measured by ELISA. The most frequent risk factors found in the patients were dyslipidemia and hypertension, this latter associated with high TIMI risk (p = 0.003). Genotype frequencies of IL6R and TNFa differed between patients with ACS and the blood donors (p = 0.0002 and p = 0.01, respectively), and TNF-α levels differed between genotypes. The TT genotype of the IL6R gene is as a possible protective factor for ACS because it was significantly more present in blood donors (32.2%) than in patients with ACS (18.0%), and was more frequent in low TIMI risk (22.9%) than in the intermediate (20.2%) or high (4.9%). In patients with ACS, the TT genotype in IL6R was related to a lower concentration of c-reactive protein (p = 0.03) and troponin (p = 0.02), showing a less inflammatory reaction and tissue damage. The differences in the frequencies of variants in genes of medical interest among the groups show the importance of studies in specific populations groups to establish the relationship between genes and diseases.engElsevierSíndrome coronariana agudaVariantes genéticasCitocinasFatores de riscoAcute coronary syndromeGenetic variantsCytokinesRisk factorsAcute coronary syndrome: Relationship between genetic variants and TIMI riskinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30734/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho VC Acute coronary syndrome...2018.pdfCarvalho VC Acute coronary syndrome...2018.pdfapplication/pdf311171https://www.arca.fiocruz.br/bitstream/icict/30734/2/Carvalho%20VC%20%20Acute%20coronary%20syndrome...2018.pdf9342df9a9a9a1db032cd7ded8c8d9386MD52TEXTCarvalho VC Acute coronary syndrome...2018.pdf.txtCarvalho VC Acute coronary syndrome...2018.pdf.txtExtracted texttext/plain34067https://www.arca.fiocruz.br/bitstream/icict/30734/3/Carvalho%20VC%20%20Acute%20coronary%20syndrome...2018.pdf.txt8f1a1a0c1829a5fd308f7c11c68e4af3MD53icict/307342023-03-15 14:34:16.222oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv Acute coronary syndrome: Relationship between genetic variants and TIMI risk
title Acute coronary syndrome: Relationship between genetic variants and TIMI risk
spellingShingle Acute coronary syndrome: Relationship between genetic variants and TIMI risk
Carvalho, Viviane do Carmo Vasconcelos de
Síndrome coronariana aguda
Variantes genéticas
Citocinas
Fatores de risco
Acute coronary syndrome
Genetic variants
Cytokines
Risk factors
title_short Acute coronary syndrome: Relationship between genetic variants and TIMI risk
title_full Acute coronary syndrome: Relationship between genetic variants and TIMI risk
title_fullStr Acute coronary syndrome: Relationship between genetic variants and TIMI risk
title_full_unstemmed Acute coronary syndrome: Relationship between genetic variants and TIMI risk
title_sort Acute coronary syndrome: Relationship between genetic variants and TIMI risk
author Carvalho, Viviane do Carmo Vasconcelos de
author_facet Carvalho, Viviane do Carmo Vasconcelos de
Silva, Lílian Caroliny Amorim
Araújo, Romário Martins
Silva Soares, Fábia Carla da
Bezerra, Maria José Ribeiro
Oliveira, Sávio Augusto Vieira de
Melo Silva, Alex José de
Montenegro, Sérgio Tavares
Werkhauser, Roberto Pereira
Silva, Carlos Gustavo Régis da
Gomes, Adriana Vieira
Morais, Clarice Neuenschwander Lins de
Montenegro, Silvia Maria Lucena
author_role author
author2 Silva, Lílian Caroliny Amorim
Araújo, Romário Martins
Silva Soares, Fábia Carla da
Bezerra, Maria José Ribeiro
Oliveira, Sávio Augusto Vieira de
Melo Silva, Alex José de
Montenegro, Sérgio Tavares
Werkhauser, Roberto Pereira
Silva, Carlos Gustavo Régis da
Gomes, Adriana Vieira
Morais, Clarice Neuenschwander Lins de
Montenegro, Silvia Maria Lucena
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Viviane do Carmo Vasconcelos de
Silva, Lílian Caroliny Amorim
Araújo, Romário Martins
Silva Soares, Fábia Carla da
Bezerra, Maria José Ribeiro
Oliveira, Sávio Augusto Vieira de
Melo Silva, Alex José de
Montenegro, Sérgio Tavares
Werkhauser, Roberto Pereira
Silva, Carlos Gustavo Régis da
Gomes, Adriana Vieira
Morais, Clarice Neuenschwander Lins de
Montenegro, Silvia Maria Lucena
dc.subject.other.pt_BR.fl_str_mv Síndrome coronariana aguda
Variantes genéticas
Citocinas
Fatores de risco
topic Síndrome coronariana aguda
Variantes genéticas
Citocinas
Fatores de risco
Acute coronary syndrome
Genetic variants
Cytokines
Risk factors
dc.subject.en.pt_BR.fl_str_mv Acute coronary syndrome
Genetic variants
Cytokines
Risk factors
description Proep APQ 1620 4.01/15.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-20T17:15:08Z
dc.date.available.fl_str_mv 2018-12-20T17:15:08Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, V. C. C. et al. Acute coronary syndrome: Relationship between genetic variants and TIMI risk. Cytokine, v. 110, p. 344–349, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30734
dc.identifier.issn.pt_BR.fl_str_mv 1043-4666
dc.identifier.doi.none.fl_str_mv 10.1016/j.cyto.2018.04.001
identifier_str_mv CARVALHO, V. C. C. et al. Acute coronary syndrome: Relationship between genetic variants and TIMI risk. Cytokine, v. 110, p. 344–349, 2018.
1043-4666
10.1016/j.cyto.2018.04.001
url https://www.arca.fiocruz.br/handle/icict/30734
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/30734/1/license.txt
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