Triterpenes and antitubercular activity of Byrsonima crassa

Detalhes bibliográficos
Autor(a) principal: Higuchi,Celio Takashi
Data de Publicação: 2008
Outros Autores: Pavan,Fernando Rogério, Leite,Clarice Queico Fujimura, Sannomiya,Miriam, Vilegas,Wagner, Leite,Sergio Roberto de Andrade, Sacramento,Luis Vitor S., Sato,Daisy Nakamura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700023
Resumo: We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.
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spelling Triterpenes and antitubercular activity of Byrsonima crassaByrsonima crassaantitubercular activitytriterpenesWe evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700023Química Nova v.31 n.7 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000700023info:eu-repo/semantics/openAccessHiguchi,Celio TakashiPavan,Fernando RogérioLeite,Clarice Queico FujimuraSannomiya,MiriamVilegas,WagnerLeite,Sergio Roberto de AndradeSacramento,Luis Vitor S.Sato,Daisy Nakamuraeng2008-12-09T00:00:00Zoai:scielo:S0100-40422008000700023Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-12-09T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Triterpenes and antitubercular activity of Byrsonima crassa
title Triterpenes and antitubercular activity of Byrsonima crassa
spellingShingle Triterpenes and antitubercular activity of Byrsonima crassa
Higuchi,Celio Takashi
Byrsonima crassa
antitubercular activity
triterpenes
title_short Triterpenes and antitubercular activity of Byrsonima crassa
title_full Triterpenes and antitubercular activity of Byrsonima crassa
title_fullStr Triterpenes and antitubercular activity of Byrsonima crassa
title_full_unstemmed Triterpenes and antitubercular activity of Byrsonima crassa
title_sort Triterpenes and antitubercular activity of Byrsonima crassa
author Higuchi,Celio Takashi
author_facet Higuchi,Celio Takashi
Pavan,Fernando Rogério
Leite,Clarice Queico Fujimura
Sannomiya,Miriam
Vilegas,Wagner
Leite,Sergio Roberto de Andrade
Sacramento,Luis Vitor S.
Sato,Daisy Nakamura
author_role author
author2 Pavan,Fernando Rogério
Leite,Clarice Queico Fujimura
Sannomiya,Miriam
Vilegas,Wagner
Leite,Sergio Roberto de Andrade
Sacramento,Luis Vitor S.
Sato,Daisy Nakamura
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Higuchi,Celio Takashi
Pavan,Fernando Rogério
Leite,Clarice Queico Fujimura
Sannomiya,Miriam
Vilegas,Wagner
Leite,Sergio Roberto de Andrade
Sacramento,Luis Vitor S.
Sato,Daisy Nakamura
dc.subject.por.fl_str_mv Byrsonima crassa
antitubercular activity
triterpenes
topic Byrsonima crassa
antitubercular activity
triterpenes
description We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000700023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.7 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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