A 21st century evil: immunopathology and new therapies of COVID-19
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44622 |
Resumo: | Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. |
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Silva, Taylon FelipeTomiotto-Pellissier, FernandaSanfelice, Raquel ArrudaGonçalves, Manoela DaieleBortoleti, Bruna Taciane da SilvaDetoni, Mariana BarbosaRodrigues, Ana Carolina JacobCarloto, Amanda Cristina MachadoConcato, Virgínia MárciaSiqueira, Elaine da SilvaCosta, Idessania NazarethPavanelli, Wander RogérioConchon-Costa, IveteMiranda-Sapla, Milena Menegazzo2020-11-25T17:33:16Z2020-11-25T17:33:16Z2020SILVA, Taylon Felipe et al. A 21st century evil: immunopathology and new therapies of COVID-19. Frontiers in Immunology, v. 11, n. 562264, p. 1-31, 2020.1664-3224https://www.arca.fiocruz.br/handle/icict/4462210.3389/fimmu.2020.562264porFrontiers MediaA 21st century evil: immunopathology and new therapies of COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Exatas. Departamento de Química. Laboratório de Biotransformação e Fitoquímica. Londrina, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Coronavirus Disease 2019 (COVID-19) has been classified as a global threat, affecting millions of people and killing thousands. It is caused by the SARS-CoV-2 virus, which emerged at the end of 2019 in Wuhan, China, quickly spreading worldwide. COVID-19 is a disease with symptoms that range from fever and breathing difficulty to acute respiratory distress and death, critically affecting older patients and people with previous comorbidities. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor and mainly spreads through the respiratory tract, which it then uses to reach several organs. The immune system of infected patients has been demonstrated to suffer important alterations, such as lymphopenia, exhausted lymphocytes, excessive amounts of inflammatory monocytes and macrophages, especially in the lungs, and cytokine storms, which may contribute to its severity and difficulty of establishing na effective treatment. Even though no specific treatment is currently available, several studies have been investigating potential therapeutic strategies, including the use of previously approved drugs and immunotherapy. In this context, this review addresses the interaction between SARS-CoV-2 and the patient’s host immune system during infection, in addition to discussing the main immunopathological mechanisms involved in the development of the disease and potential new therapeutic approaches.Severe Acute Respiratory Syndrome Coronavirus 2Coronavirus InfectionsImmunologyPathologyCytokineImmunotherapyCOVID-19Infecciones por CoronavirusInmunologíaPatologíaInmunoterapiaCOVID-19Infections à coronavirusImmunologieAnatomopathologieImmunothérapieCOVID-19COVID-19Infecções por CoronavirusImunologiaPatologiaCitocinaImunoterapiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
A 21st century evil: immunopathology and new therapies of COVID-19 |
| title |
A 21st century evil: immunopathology and new therapies of COVID-19 |
| spellingShingle |
A 21st century evil: immunopathology and new therapies of COVID-19 Silva, Taylon Felipe Severe Acute Respiratory Syndrome Coronavirus 2 Coronavirus Infections Immunology Pathology Cytokine Immunotherapy COVID-19 Infecciones por Coronavirus Inmunología Patología Inmunoterapia COVID-19 Infections à coronavirus Immunologie Anatomopathologie Immunothérapie COVID-19 COVID-19 Infecções por Coronavirus Imunologia Patologia Citocina Imunoterapia |
| title_short |
A 21st century evil: immunopathology and new therapies of COVID-19 |
| title_full |
A 21st century evil: immunopathology and new therapies of COVID-19 |
| title_fullStr |
A 21st century evil: immunopathology and new therapies of COVID-19 |
| title_full_unstemmed |
A 21st century evil: immunopathology and new therapies of COVID-19 |
| title_sort |
A 21st century evil: immunopathology and new therapies of COVID-19 |
| author |
Silva, Taylon Felipe |
| author_facet |
Silva, Taylon Felipe Tomiotto-Pellissier, Fernanda Sanfelice, Raquel Arruda Gonçalves, Manoela Daiele Bortoleti, Bruna Taciane da Silva Detoni, Mariana Barbosa Rodrigues, Ana Carolina Jacob Carloto, Amanda Cristina Machado Concato, Virgínia Márcia Siqueira, Elaine da Silva Costa, Idessania Nazareth Pavanelli, Wander Rogério Conchon-Costa, Ivete Miranda-Sapla, Milena Menegazzo |
| author_role |
author |
| author2 |
Tomiotto-Pellissier, Fernanda Sanfelice, Raquel Arruda Gonçalves, Manoela Daiele Bortoleti, Bruna Taciane da Silva Detoni, Mariana Barbosa Rodrigues, Ana Carolina Jacob Carloto, Amanda Cristina Machado Concato, Virgínia Márcia Siqueira, Elaine da Silva Costa, Idessania Nazareth Pavanelli, Wander Rogério Conchon-Costa, Ivete Miranda-Sapla, Milena Menegazzo |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Taylon Felipe Tomiotto-Pellissier, Fernanda Sanfelice, Raquel Arruda Gonçalves, Manoela Daiele Bortoleti, Bruna Taciane da Silva Detoni, Mariana Barbosa Rodrigues, Ana Carolina Jacob Carloto, Amanda Cristina Machado Concato, Virgínia Márcia Siqueira, Elaine da Silva Costa, Idessania Nazareth Pavanelli, Wander Rogério Conchon-Costa, Ivete Miranda-Sapla, Milena Menegazzo |
| dc.subject.en.pt_BR.fl_str_mv |
Severe Acute Respiratory Syndrome Coronavirus 2 Coronavirus Infections Immunology Pathology Cytokine Immunotherapy COVID-19 |
| topic |
Severe Acute Respiratory Syndrome Coronavirus 2 Coronavirus Infections Immunology Pathology Cytokine Immunotherapy COVID-19 Infecciones por Coronavirus Inmunología Patología Inmunoterapia COVID-19 Infections à coronavirus Immunologie Anatomopathologie Immunothérapie COVID-19 COVID-19 Infecções por Coronavirus Imunologia Patologia Citocina Imunoterapia |
| dc.subject.es.pt_BR.fl_str_mv |
Infecciones por Coronavirus Inmunología Patología Inmunoterapia COVID-19 |
| dc.subject.fr.pt_BR.fl_str_mv |
Infections à coronavirus Immunologie Anatomopathologie Immunothérapie COVID-19 |
| dc.subject.decs.pt_BR.fl_str_mv |
COVID-19 Infecções por Coronavirus Imunologia Patologia Citocina Imunoterapia |
| description |
Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. |
| publishDate |
2020 |
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2020-11-25T17:33:16Z |
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2020-11-25T17:33:16Z |
| dc.date.issued.fl_str_mv |
2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SILVA, Taylon Felipe et al. A 21st century evil: immunopathology and new therapies of COVID-19. Frontiers in Immunology, v. 11, n. 562264, p. 1-31, 2020. |
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https://www.arca.fiocruz.br/handle/icict/44622 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2020.562264 |
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SILVA, Taylon Felipe et al. A 21st century evil: immunopathology and new therapies of COVID-19. Frontiers in Immunology, v. 11, n. 562264, p. 1-31, 2020. 1664-3224 10.3389/fimmu.2020.562264 |
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Frontiers Media |
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Frontiers Media |
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