An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences

Detalhes bibliográficos
Autor(a) principal: Carels, Nicolas
Data de Publicação: 2015
Outros Autores: Leon, Miguel Ponce de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20983
Resumo: Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
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spelling Carels, NicolasLeon, Miguel Ponce de2017-09-12T18:07:06Z2017-09-12T18:07:06Z2015CARELS, N. et al. An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences. Bioinformatics and Biology Insights, v. 9, p. 37-47, 2015.1177-9322https://www.arca.fiocruz.br/handle/icict/20983engSAGE Publishinggenômicacaracterísticas proteicascodon ancestralgenomicsprotein featuresancestral codonpurine biasshort-range correlationsAn Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequencesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.Universidad Complutense de Madrid. Facultad de Ciencias Químicas. Departamento de Bioquímica y Biología Molecular I. Madrid, Spain.Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-range correlations between nucleotides in coding sequences, and it is common in all species. We demonstrate that RW Y is a more appropriate pattern than the classical RNY, and purine bias (Rrr) is the product of a network of nucleotide compensations induced by functional constraints on the physicochemical properties of proteins. Through deductions from universal correlation properties, we also demonstrate that amino acids from Miller’s spark discharge experiment are compatible with functional primeval proteins at the dawn of living cell radiation on earth. These amino acids match the hydropathy and secondary structures of modern proteins.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83101https://www.arca.fiocruz.br/bitstream/icict/20983/1/license.txt425ef259bcb460998407fbfed7c102d0MD51ORIGINALCarels_etal_2015b.pdfCarels_etal_2015b.pdfapplication/pdf1356166https://www.arca.fiocruz.br/bitstream/icict/20983/2/Carels_etal_2015b.pdfb1ae72109c0734b9db6b4b9e179ea790MD52TEXTCarels_etal_2015b.pdf.txtCarels_etal_2015b.pdf.txtExtracted texttext/plain61840https://www.arca.fiocruz.br/bitstream/icict/20983/3/Carels_etal_2015b.pdf.txt99055cf4f0e10da2ee8d0f24700b5aeaMD53icict/209832018-08-15 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dc.title.pt_BR.fl_str_mv An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
spellingShingle An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
Carels, Nicolas
genômica
características proteicas
codon ancestral
genomics
protein features
ancestral codon
purine bias
short-range correlations
title_short An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_full An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_fullStr An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_full_unstemmed An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
title_sort An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences
author Carels, Nicolas
author_facet Carels, Nicolas
Leon, Miguel Ponce de
author_role author
author2 Leon, Miguel Ponce de
author2_role author
dc.contributor.author.fl_str_mv Carels, Nicolas
Leon, Miguel Ponce de
dc.subject.other.pt_BR.fl_str_mv genômica
características proteicas
codon ancestral
topic genômica
características proteicas
codon ancestral
genomics
protein features
ancestral codon
purine bias
short-range correlations
dc.subject.en.pt_BR.fl_str_mv genomics
protein features
ancestral codon
purine bias
short-range correlations
description Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-09-12T18:07:06Z
dc.date.available.fl_str_mv 2017-09-12T18:07:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARELS, N. et al. An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences. Bioinformatics and Biology Insights, v. 9, p. 37-47, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20983
dc.identifier.issn.pt_BR.fl_str_mv 1177-9322
identifier_str_mv CARELS, N. et al. An Interpretation of the Ancestral Codon from Miller’s Amino Acids and Nucleotide Correlations in Modern Coding Sequences. Bioinformatics and Biology Insights, v. 9, p. 37-47, 2015.
1177-9322
url https://www.arca.fiocruz.br/handle/icict/20983
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE Publishing
publisher.none.fl_str_mv SAGE Publishing
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/20983/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/20983/2/Carels_etal_2015b.pdf
https://www.arca.fiocruz.br/bitstream/icict/20983/3/Carels_etal_2015b.pdf.txt
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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