Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C

Detalhes bibliográficos
Autor(a) principal: Saraiva, Geórgia Nascimento
Data de Publicação: 2018
Outros Autores: Rosário, Natalia Fonseca do, Medeiros, Thalia, Leite, Paulo Emílio Côrrea, Lacerda, Gilmar de Souza, Andrade, Thaís Guaraná de, Azeredo, Elzinandes Leal de, Ancuta, Petronela, Almeida, Jorge Reis, Xavier, Analúcia Rampazzo, Silva, Andrea Alice
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31346
Resumo: Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.
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spelling Saraiva, Geórgia NascimentoRosário, Natalia Fonseca doMedeiros, ThaliaLeite, Paulo Emílio CôrreaLacerda, Gilmar de SouzaAndrade, Thaís Guaraná deAzeredo, Elzinandes Leal deAncuta, PetronelaAlmeida, Jorge ReisXavier, Analúcia RampazzoSilva, Andrea Alice2019-01-29T15:46:12Z2019-01-29T15:46:12Z2018SARAIVA, Geórgia Nascimento; et al. Restoring Inflammatory Mediator Balance after Sofosbuvir- Induced Viral Clearance in Patients with Chronic Hepatitis C. Mediators of Inflammation, Volume 2018, Article ID 8578051, 12p, 2018.0962-9351https://www.arca.fiocruz.br/handle/icict/3134610.1155/2018/85780511466-1861engHindawi Publishing CorporationSofosbuvirHepatite C CrônicaPacientesDepuração Viral InduzidaBalanço do Mediador InflamatórioSofosbuvirChronic Hepatitis CPatientsInduced Viral ClearanceInflammatory Mediator BalanceRestoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis Cinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Ultraestrutura Celular Hertha Meyer. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Patologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Medicina Clínica. Serviço de Gastroenterologia. Centro de Referência de Tratamento em Hepatites/HUAP. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Université de Montréal. Centre de Recherche du CHUM. Department of Microbiology, Infectiology and Immunology. Montreal, Canada.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Patologia. Niterói, RJ, Brasil..Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil / Universidade Federal Fluminense. Faculdade de Medicina. Departamento de Patologia. Niterói, RJ, Brasil..This study aimed at analyzing circulating levels of inflammatory and profibrogenic cytokines in patients with hepatitis C virus (HCV) chronic infection undergoing therapy with direct-acting antiviral agents (DAA) and correlating these immune biomarkers with liver disease status. We studied 88 Brazilian monoinfected chronic hepatitis C patients receiving interferon- (IFN-) free sofosbuvir-based regimens for 12 or 24 weeks, followed-up before therapy initiation and three months after the end of treatment. Liver disease was determined by transient elastography, in addition to APRI and FIB-4 indexes. Analysis of 30 immune mediators was carried out by multiplex or enzymatic immunoassays. Sustained virological response rate was 98.9%. Serum levels of cytokines were increased in HCV-infected patients when compared to control group. CCL-2, CCL-3, CCL-4, CXCL-8, CXCL-10, IL-1β, IL-15, IFN-γ, IL-4, IL-10, TGF-β, FGFb, and PAI-1 decreased significantly after antiviral therapy, reaching values similar to noninfected controls. TGF-β and suPAR levels were associated with fibrosis/cirrhosis. Also, we observed amelioration in hepatic parameters after DAA treatment. Together, our results suggest that viral control induced by IFN-free DAA therapy restores inflammatory mediators in association with improvement in liver function.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31346/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALelizinandesL_azevedo_etal_IOC_2018.pdfelizinandesL_azevedo_etal_IOC_2018.pdfapplication/pdf2422118https://www.arca.fiocruz.br/bitstream/icict/31346/2/elizinandesL_azevedo_etal_IOC_2018.pdf5e9a8f1bae99ba96aec2c59a137893dfMD52TEXTelizinandesL_azevedo_etal_IOC_2018.pdf.txtelizinandesL_azevedo_etal_IOC_2018.pdf.txtExtracted texttext/plain54568https://www.arca.fiocruz.br/bitstream/icict/31346/3/elizinandesL_azevedo_etal_IOC_2018.pdf.txt7610108a46d38a6a3759b09b8945a062MD53icict/313462019-01-30 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dc.title.pt_BR.fl_str_mv Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
title Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
spellingShingle Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
Saraiva, Geórgia Nascimento
Sofosbuvir
Hepatite C Crônica
Pacientes
Depuração Viral Induzida
Balanço do Mediador Inflamatório
Sofosbuvir
Chronic Hepatitis C
Patients
Induced Viral Clearance
Inflammatory Mediator Balance
title_short Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
title_full Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
title_fullStr Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
title_full_unstemmed Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
title_sort Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
author Saraiva, Geórgia Nascimento
author_facet Saraiva, Geórgia Nascimento
Rosário, Natalia Fonseca do
Medeiros, Thalia
Leite, Paulo Emílio Côrrea
Lacerda, Gilmar de Souza
Andrade, Thaís Guaraná de
Azeredo, Elzinandes Leal de
Ancuta, Petronela
Almeida, Jorge Reis
Xavier, Analúcia Rampazzo
Silva, Andrea Alice
author_role author
author2 Rosário, Natalia Fonseca do
Medeiros, Thalia
Leite, Paulo Emílio Côrrea
Lacerda, Gilmar de Souza
Andrade, Thaís Guaraná de
Azeredo, Elzinandes Leal de
Ancuta, Petronela
Almeida, Jorge Reis
Xavier, Analúcia Rampazzo
Silva, Andrea Alice
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Saraiva, Geórgia Nascimento
Rosário, Natalia Fonseca do
Medeiros, Thalia
Leite, Paulo Emílio Côrrea
Lacerda, Gilmar de Souza
Andrade, Thaís Guaraná de
Azeredo, Elzinandes Leal de
Ancuta, Petronela
Almeida, Jorge Reis
Xavier, Analúcia Rampazzo
Silva, Andrea Alice
dc.subject.other.pt_BR.fl_str_mv Sofosbuvir
Hepatite C Crônica
Pacientes
Depuração Viral Induzida
Balanço do Mediador Inflamatório
topic Sofosbuvir
Hepatite C Crônica
Pacientes
Depuração Viral Induzida
Balanço do Mediador Inflamatório
Sofosbuvir
Chronic Hepatitis C
Patients
Induced Viral Clearance
Inflammatory Mediator Balance
dc.subject.en.pt_BR.fl_str_mv Sofosbuvir
Chronic Hepatitis C
Patients
Induced Viral Clearance
Inflammatory Mediator Balance
description Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Faculdade de Medicina. Laboratório Multiusuário de Apoio à Pesquisa em Nefrologia e Ciências Médicas. Niterói, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-29T15:46:12Z
dc.date.available.fl_str_mv 2019-01-29T15:46:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SARAIVA, Geórgia Nascimento; et al. Restoring Inflammatory Mediator Balance after Sofosbuvir- Induced Viral Clearance in Patients with Chronic Hepatitis C. Mediators of Inflammation, Volume 2018, Article ID 8578051, 12p, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31346
dc.identifier.issn.pt_BR.fl_str_mv 0962-9351
dc.identifier.doi.none.fl_str_mv 10.1155/2018/8578051
dc.identifier.eissn.none.fl_str_mv 1466-1861
identifier_str_mv SARAIVA, Geórgia Nascimento; et al. Restoring Inflammatory Mediator Balance after Sofosbuvir- Induced Viral Clearance in Patients with Chronic Hepatitis C. Mediators of Inflammation, Volume 2018, Article ID 8578051, 12p, 2018.
0962-9351
10.1155/2018/8578051
1466-1861
url https://www.arca.fiocruz.br/handle/icict/31346
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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