Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10396 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil. |
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Limonta, DanielCarvalho, Amanda TorrentesMarinho, Cíntia FerreiraAzeredo, Elzinandes Leal deSouza, Luiz José deCastro, Ana Rita C. MottaCunha, Rivaldo VenâncioKubelka, Claire FernandesNogueira, Rita Maria RibeiroPinto, Luzia Maria de Oliveira2015-05-19T13:26:04Z2015-05-19T13:26:04Z2014LIMONTA, Daniel et al. Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil. Journal of Medical Virology, v.86, n.8, p.1437–1447, 2014.1096-9071https://www.arca.fiocruz.br/handle/icict/1039610.1002/jmv.23832engWiley Periodicals, INCApoptosePatogêneseMonócitosApoptosisPathogenesisPhocytesMonocytesApoptoseMonócitosApoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Centro Regional de Referência em Dengue. Campos dos Goytacazes, Rio de Janeiro, RJ, Brasil.Universidade Federal do Mato Grosso. Setor Hemonúcleo. MS, Brasil.Universidade Federal do Mato Grosso. Setor Hemonúcleo. MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Despite being the most significant arboviral disease worldwide, dengue has no antiviral treatment or reliable severity predictors. It has been shown that apoptotic cells from blood and tissues may be involved in the complex pathogenesis of dengue. However, very little is known about the interplay between proapoptotic and antiapoptotic mediators in this disease. Therefore, plasma levels of the three proapoptotic mediators Fas ligand (FasL), tumor necrosis factor-α (TNF-α), and TNF-related apoptosis-inducing ligand (TRAIL) were measured in dengue patients. Patients were classified according to the World Health Organization classification of dengue revised in 2009. Additionally, inhibitors of apoptosis protein (IAPs) were determined in plasma (Survivin) and peripheral blood mononuclear cells (PBMCs) lysates (cIAP-1, cIAP-2, XIAP). Levels of apoptotic proteins in plasma were correlated with counts of blood cells. FasL and TRAIL levels were elevated in dengue patients without warning signs when compared to patients with severe dengue and controls. Dengue patients with warning signs showed decreased levels of Survivin compared to patients with severe dengue and controls. TRAIL was inversely correlated with counts of lymphocyte subsets. In contrast, Survivin was positively correlated with leukocyte counts. There was a trend of elevated IAPs levels in PBMCs of patients with severe dengue. The results suggest a likely antiviral effect of TRAIL in dengue. It appears that TRAIL might be involved with apoptosis induction of lymphocytes, whereas IAPs might participate in protecting leukocytes from apoptosis. Further research is needed to explore the interactions between pro and antiapoptotic molecules and their implications in dengue pathogenesis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10396/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALdaniel_limontaetal_IOC-2014.pdfapplication/pdf426000https://www.arca.fiocruz.br/bitstream/icict/10396/2/daniel_limontaetal_IOC-2014.pdfecf2fec79eeb98d9011dda423c5c8596MD52icict/103962022-06-24 12:19:36.8oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:19:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil |
| title |
Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil |
| spellingShingle |
Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil Limonta, Daniel Apoptose Patogênese Monócitos Apoptosis Pathogenesis Phocytes Monocytes Apoptose Monócitos |
| title_short |
Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil |
| title_full |
Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil |
| title_fullStr |
Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil |
| title_full_unstemmed |
Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil |
| title_sort |
Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil |
| author |
Limonta, Daniel |
| author_facet |
Limonta, Daniel Carvalho, Amanda Torrentes Marinho, Cíntia Ferreira Azeredo, Elzinandes Leal de Souza, Luiz José de Castro, Ana Rita C. Motta Cunha, Rivaldo Venâncio Kubelka, Claire Fernandes Nogueira, Rita Maria Ribeiro Pinto, Luzia Maria de Oliveira |
| author_role |
author |
| author2 |
Carvalho, Amanda Torrentes Marinho, Cíntia Ferreira Azeredo, Elzinandes Leal de Souza, Luiz José de Castro, Ana Rita C. Motta Cunha, Rivaldo Venâncio Kubelka, Claire Fernandes Nogueira, Rita Maria Ribeiro Pinto, Luzia Maria de Oliveira |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Limonta, Daniel Carvalho, Amanda Torrentes Marinho, Cíntia Ferreira Azeredo, Elzinandes Leal de Souza, Luiz José de Castro, Ana Rita C. Motta Cunha, Rivaldo Venâncio Kubelka, Claire Fernandes Nogueira, Rita Maria Ribeiro Pinto, Luzia Maria de Oliveira |
| dc.subject.other.pt_BR.fl_str_mv |
Apoptose Patogênese Monócitos |
| topic |
Apoptose Patogênese Monócitos Apoptosis Pathogenesis Phocytes Monocytes Apoptose Monócitos |
| dc.subject.en.pt_BR.fl_str_mv |
Apoptosis Pathogenesis Phocytes Monocytes |
| dc.subject.decs.pt_BR.fl_str_mv |
Apoptose Monócitos |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil. |
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2014 |
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2014 |
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2015-05-19T13:26:04Z |
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2015-05-19T13:26:04Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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LIMONTA, Daniel et al. Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil. Journal of Medical Virology, v.86, n.8, p.1437–1447, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10396 |
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1096-9071 |
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10.1002/jmv.23832 |
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LIMONTA, Daniel et al. Apoptotic Mediators in Patients With Severe and Non-Severe Dengue From Brazil. Journal of Medical Virology, v.86, n.8, p.1437–1447, 2014. 1096-9071 10.1002/jmv.23832 |
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Wiley Periodicals, INC |
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