Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31362 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. |
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Souza, Thiara Manuele Alves de SouzaNogueira, Fernanda de BruyckerCarneiro, Thaís ChouinFaria, Nieli Rodrigues da CostaNunes, Priscila Conrado GuerraHeringer, ManoelaLima, Monique da Rocha QueirozCorrêa, Jéssica BadolatoCipitelli, Márcio da CostaAzereedo, Elzinandes Leal deNogueira, Rita Maria RibeiroSantos, Flávia Barreto dosRibeiro, Edcelha D`AthaideCorrêa, Valmir Corrêa eDamasco, Paulo VieiraSantos, Carla Cunha2019-01-31T15:32:23Z2019-01-31T15:32:23Z2018SOUZA, Thiara Manuele Alves de; et al. Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016. Viruses, v.10, n.623, 17p, 2018.1999-4915https://www.arca.fiocruz.br/handle/icict/3136210.3390/v101106231999-4915engMDPIChikungunya vírusCoinfecçãoVigilânciaGenótipo asiáticoBrasilChikungunya virusSurveillanceco-infectionECSA genotypeAsian genotypeBrazilFollowing in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil.Laboratório Central do Amapá. Macapá, AP, Brasil.Laboratório de Fronteira. Oiapoque, AP, Brasil.Rio-Laranjeiras Hospital. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro. RJ, Brasil.Rio-Laranjeiras Hospital. Rio de Janeiro, RJ, BrasilCurrently, Brazil lives a triple arboviruses epidemic (DENV, ZIKV and CHIKV) making the differential diagnosis difficult for health professionals. Here, we aimed to investigate chikungunya cases and the possible occurrence of co-infections during the epidemic in Amapá (AP) that started in 2014 when the first autochthonous cases were reported and in Rio de Janeiro (RJ) in 2016. We further performed molecular characterization and genotyping of representative strains. In AP, 51.4% of the suspected cases were confirmed for CHIKV, 71.0% (76/107). Of those, 24 co-infections by CHIKV/DENV, two by CHIKV/DENV-1, and two by CHIKV/DENV-4 were observed. In RJ, 76.9% of the suspected cases were confirmed for CHIKV and co-infections by CHIKV/DENV (n = 8) and by CHIKV/ZIKV (n = 17) were observed. Overall, fever, arthralgia, myalgia, prostration, edema, exanthema, conjunctival hyperemia, lower back pain, dizziness, nausea, retroorbital pain, and anorexia were the predominating chikungunya clinical symptoms described. All strains analyzed from AP belonged to the Asian genotype and no amino acid changes were observed. In RJ, the East-Central-South-African genotype (ECSA) circulation was demonstrated and no E1-A226V mutation was observed. Despite this, an E1-V156A substitution was characterized in two samples and for the first time, the E1-K211T mutation was reported in all samples analyzed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31362/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALthiaramanuele_etal_IOC_2018.pdfthiaramanuele_etal_IOC_2018.pdfapplication/pdf862926https://www.arca.fiocruz.br/bitstream/icict/31362/2/thiaramanuele_etal_IOC_2018.pdf661c9df2e7d772ae6cb22fea43c7b11aMD52TEXTthiaramanuele_etal_IOC_2018.pdf.txtthiaramanuele_etal_IOC_2018.pdf.txtExtracted texttext/plain65217https://www.arca.fiocruz.br/bitstream/icict/31362/3/thiaramanuele_etal_IOC_2018.pdf.txt3847da3a990bbb1064fbcc3c9c1572a6MD53icict/313622019-02-01 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Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 |
| title |
Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 |
| spellingShingle |
Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 Souza, Thiara Manuele Alves de Souza Chikungunya vírus Coinfecção Vigilância Genótipo asiático Brasil Chikungunya virus Surveillance co-infection ECSA genotype Asian genotype Brazil |
| title_short |
Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 |
| title_full |
Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 |
| title_fullStr |
Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 |
| title_full_unstemmed |
Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 |
| title_sort |
Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 |
| author |
Souza, Thiara Manuele Alves de Souza |
| author_facet |
Souza, Thiara Manuele Alves de Souza Nogueira, Fernanda de Bruycker Carneiro, Thaís Chouin Faria, Nieli Rodrigues da Costa Nunes, Priscila Conrado Guerra Heringer, Manoela Lima, Monique da Rocha Queiroz Corrêa, Jéssica Badolato Cipitelli, Márcio da Costa Azereedo, Elzinandes Leal de Nogueira, Rita Maria Ribeiro Santos, Flávia Barreto dos Ribeiro, Edcelha D`Athaide Corrêa, Valmir Corrêa e Damasco, Paulo Vieira Santos, Carla Cunha |
| author_role |
author |
| author2 |
Nogueira, Fernanda de Bruycker Carneiro, Thaís Chouin Faria, Nieli Rodrigues da Costa Nunes, Priscila Conrado Guerra Heringer, Manoela Lima, Monique da Rocha Queiroz Corrêa, Jéssica Badolato Cipitelli, Márcio da Costa Azereedo, Elzinandes Leal de Nogueira, Rita Maria Ribeiro Santos, Flávia Barreto dos Ribeiro, Edcelha D`Athaide Corrêa, Valmir Corrêa e Damasco, Paulo Vieira Santos, Carla Cunha |
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author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Thiara Manuele Alves de Souza Nogueira, Fernanda de Bruycker Carneiro, Thaís Chouin Faria, Nieli Rodrigues da Costa Nunes, Priscila Conrado Guerra Heringer, Manoela Lima, Monique da Rocha Queiroz Corrêa, Jéssica Badolato Cipitelli, Márcio da Costa Azereedo, Elzinandes Leal de Nogueira, Rita Maria Ribeiro Santos, Flávia Barreto dos Ribeiro, Edcelha D`Athaide Corrêa, Valmir Corrêa e Damasco, Paulo Vieira Santos, Carla Cunha |
| dc.subject.other.pt_BR.fl_str_mv |
Chikungunya vírus Coinfecção Vigilância Genótipo asiático Brasil |
| topic |
Chikungunya vírus Coinfecção Vigilância Genótipo asiático Brasil Chikungunya virus Surveillance co-infection ECSA genotype Asian genotype Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Chikungunya virus Surveillance co-infection ECSA genotype Asian genotype Brazil |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. |
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2018 |
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2018 |
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2019-01-31T15:32:23Z |
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2019-01-31T15:32:23Z |
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SOUZA, Thiara Manuele Alves de; et al. Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016. Viruses, v.10, n.623, 17p, 2018. |
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1999-4915 |
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10.3390/v10110623 |
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1999-4915 |
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SOUZA, Thiara Manuele Alves de; et al. Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016. Viruses, v.10, n.623, 17p, 2018. 1999-4915 10.3390/v10110623 |
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