The 2019-new coronavirus epidemic: Evidence for virus evolution

Detalhes bibliográficos
Autor(a) principal: Benvenuto, Domenico
Data de Publicação: 2020
Outros Autores: Giovanetti, Marta, Ciccozzi, Alessandra, Spoto, Silvia, Angeletti, Silvia, Ciccozzi, Massimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40020
Resumo: Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.
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spelling Benvenuto, DomenicoGiovanetti, MartaCiccozzi, AlessandraSpoto, SilviaAngeletti, SilviaCiccozzi, Massimo2020-02-17T18:53:28Z2020-02-17T18:53:28Z2020BENVENUTO, Domenico et al. The 2019‐new coronavirus epidemic: Evidence for virus evolution. Journal of Medical Virology, p. 1-5, 2020.0146-6615https://www.arca.fiocruz.br/handle/icict/4002010.1002/jmv.256881096-9071Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.Em decorrência da pandemia decretada pela OMS em 2020, o artigo encontra-se em acesso aberto.University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University Campus Bio‐Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.University Campus Bio‐Medico of Rome. Internal Medicine Unit. Rome, Italy.University Campus Bio‐Medico of Rome. Unit of Clinical Laboratory Sciences. Rome, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.There is a worldwide concern about the new coronavirus 2019-nCoV as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequences of 2019-nCoV, 12 whole genome sequences of 2019-nCoV, and 12 highly similar whole genome sequences available in gene bank (five from the severe acute respiratory syndrome, two from Middle East respiratory syndrome, and five from bat SARS-like coronavirus). Fast unconstrained Bayesian approximation analysis shows that the nucleocapsid and the spike glycoprotein have some sites under positive pressure, whereas homology modeling revealed some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019-nCoV significantly clustered with bat SARS-like coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. From these results, the new 2019-nCoV is distinct from SARS virus, probably trasmitted from bats after mutation conferring ability to infect humans.engWileyhttps://www.arca.fiocruz.br/handle/icict/40022CoronavírusEpidemiologiaCoronavirusDesign macromolecularCoronavirusMacromolecular designCoronavirusEpidemiologyCOVID-19The 2019-new coronavirus epidemic: Evidence for virus evolutioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv The 2019-new coronavirus epidemic: Evidence for virus evolution
title The 2019-new coronavirus epidemic: Evidence for virus evolution
spellingShingle The 2019-new coronavirus epidemic: Evidence for virus evolution
Benvenuto, Domenico
Coronavírus
Epidemiologia
Coronavirus
Design macromolecular
Coronavirus
Macromolecular design
Coronavirus
Epidemiology
COVID-19
title_short The 2019-new coronavirus epidemic: Evidence for virus evolution
title_full The 2019-new coronavirus epidemic: Evidence for virus evolution
title_fullStr The 2019-new coronavirus epidemic: Evidence for virus evolution
title_full_unstemmed The 2019-new coronavirus epidemic: Evidence for virus evolution
title_sort The 2019-new coronavirus epidemic: Evidence for virus evolution
author Benvenuto, Domenico
author_facet Benvenuto, Domenico
Giovanetti, Marta
Ciccozzi, Alessandra
Spoto, Silvia
Angeletti, Silvia
Ciccozzi, Massimo
author_role author
author2 Giovanetti, Marta
Ciccozzi, Alessandra
Spoto, Silvia
Angeletti, Silvia
Ciccozzi, Massimo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Benvenuto, Domenico
Giovanetti, Marta
Ciccozzi, Alessandra
Spoto, Silvia
Angeletti, Silvia
Ciccozzi, Massimo
dc.subject.other.pt_BR.fl_str_mv Coronavírus
Epidemiologia
Coronavirus
Design macromolecular
topic Coronavírus
Epidemiologia
Coronavirus
Design macromolecular
Coronavirus
Macromolecular design
Coronavirus
Epidemiology
COVID-19
dc.subject.en.pt_BR.fl_str_mv Coronavirus
Macromolecular design
Coronavirus
Epidemiology
COVID-19
description Devido a pandemia mundial do COVID-19, o artigo da revista foi liberado em acesso aberto durante o ano de 2020, visando divulgação e disseminação.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-02-17T18:53:28Z
dc.date.available.fl_str_mv 2020-02-17T18:53:28Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BENVENUTO, Domenico et al. The 2019‐new coronavirus epidemic: Evidence for virus evolution. Journal of Medical Virology, p. 1-5, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40020
dc.identifier.issn.pt_BR.fl_str_mv 0146-6615
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.25688
dc.identifier.eissn.none.fl_str_mv 1096-9071
identifier_str_mv BENVENUTO, Domenico et al. The 2019‐new coronavirus epidemic: Evidence for virus evolution. Journal of Medical Virology, p. 1-5, 2020.
0146-6615
10.1002/jmv.25688
1096-9071
url https://www.arca.fiocruz.br/handle/icict/40020
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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