CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13053 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil / Sorbonne Universités, UPMC Univ Paris 06, UM76, INSERM U974, CNRS FRE3617, Center for Research in Myology, 47 boulevard de l’Hopital, Paris 75651, France. |
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Mariz, Fernanda PintoCarvalho, Luciana RodriguesAraujo, Alexandra Prufer De Queiroz CamposMello, Wallace DeRibeiro, Márcia GonçalvesCunha, Maria Do Carmo Soares AlvesCabello, Pedro HernanRiederer, IngoNegroni, ElisaDesguerre, IsabelleVeras, MarianaYada, EricaAllenbach, YvesBenveniste, OlivierVoit, ThomasMouly, VincentBarbosa, Suse Dayse SilvaButler-Browne, GillianSavino, Wilson2016-03-08T14:27:12Z2016-03-08T14:27:12Z2015MARIZ, Fernanda Pinto; et al. CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy. Skeletal Muscle, v.5:45, 10p, Dec. 2015.2044-5040https://www.arca.fiocruz.br/handle/icict/1305310.1186/s13395-015-0066-2engBioMed CentralBiomarcador preditivoDuchenne muscular dystrophyInflammationCD49dT lymphocytesPredictive biomarkerImmunotherapyDistrofia Muscular de DuchenneInflamaçãoLinfócitos TImunoterapiaCD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil / Sorbonne Universités, UPMC Univ Paris 06, UM76, INSERM U974, CNRS FRE3617, Center for Research in Myology, 47 boulevard de l’Hopital, Paris 75651, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.Université Pierre et Marie Curie. Service de Médecine Interne. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Sorbonne Universités, UPMC Univ Paris 06, UM76, INSERM U974, CNRS FRE3617. Center for Research in Myology, 47 boulevard de l’Hopital. Paris 75651, FranceINSERM U-E10.Necker Hospital. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Sorbonne Universités, UPMC Univ Paris 06, UM76, INSERM U974, CNRS FRE3617. Center for Research in Myology, 47 boulevard de l’Hopital. Paris 75651, FranceUniversité Pierre et Marie Curie. Service de Médecine Interne. Paris, France.Université Pierre et Marie Curie. Service de Médecine Interne. Paris, France.Sorbonne Universités, UPMC Univ Paris 06, UM76, INSERM U974, CNRS FRE3617. Center for Research in Myology, 47 boulevard de l’Hopital. Paris 75651, FranceSorbonne Universités, UPMC Univ Paris 06, UM76, INSERM U974, CNRS FRE3617. Center for Research in Myology, 47 boulevard de l’Hopital. Paris 75651, FranceFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer (INCA). Departamento de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Sorbonne Universités, UPMC Univ Paris 06, UM76, INSERM U974, CNRS FRE3617. Center for Research in Myology, 47 boulevard de l’Hopital. Paris 75651, FranceFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Background Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene. The immune inflammatory response also contributes to disease progression in DMD patients. In a previous study, we demonstrated higher levels of circulating CD49dhi and CD49ehi T cells in DMD patients compared to healthy control. DMD patients are clinically heterogeneous and the functional defect cannot be correlated with genotype. Therefore, it is important to be able to define reliable noninvasive biomarkers to better define the disease progression at the beginning of clinical trials. Results We studied 75 DMD patients at different stages of their disease and observed that increased percentages of circulating CD4+CD49dhi and CD8+CD49dhi T lymphocytes were correlated with both severity and a more rapid progression of the disease. Moreover, T+CD49d+ cells were also found in muscular inflammatory infiltrates. Functionally, T cells from severely affected patients exhibited higher transendothelial and fibronectin-driven migratory responses and increased adhesion to myotubes, when compared to control individuals. These responses could be blocked with an anti-CD49d monoclonal antibody. Conclusion CD49d can be used as a novel biomarker to stratify DMD patients by predicting disease progression for clinical trials. Moreover, anti-CD49d peptides or antibodies can be used as a therapeutic approach to decrease inflammation-mediated tissue damage in DMD.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13053/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALluciana_carvalho_etal_IOC_2015.pdfluciana_carvalho_etal_IOC_2015.pdfapplication/pdf1197534https://www.arca.fiocruz.br/bitstream/icict/13053/2/luciana_carvalho_etal_IOC_2015.pdfbcb0a44ff636b764b50f12dc733107e6MD52TEXTluciana_carvalho_etal_IOC_2015.pdf.txtluciana_carvalho_etal_IOC_2015.pdf.txtExtracted texttext/plain43898https://www.arca.fiocruz.br/bitstream/icict/13053/3/luciana_carvalho_etal_IOC_2015.pdf.txtad3651910b8cbdf2be1c6168c92b5487MD53icict/130532018-04-02 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| dc.title.pt_BR.fl_str_mv |
CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy |
| title |
CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy |
| spellingShingle |
CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy Mariz, Fernanda Pinto Biomarcador preditivo Duchenne muscular dystrophy Inflammation CD49d T lymphocytes Predictive biomarker Immunotherapy Distrofia Muscular de Duchenne Inflamação Linfócitos T Imunoterapia |
| title_short |
CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy |
| title_full |
CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy |
| title_fullStr |
CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy |
| title_full_unstemmed |
CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy |
| title_sort |
CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy |
| author |
Mariz, Fernanda Pinto |
| author_facet |
Mariz, Fernanda Pinto Carvalho, Luciana Rodrigues Araujo, Alexandra Prufer De Queiroz Campos Mello, Wallace De Ribeiro, Márcia Gonçalves Cunha, Maria Do Carmo Soares Alves Cabello, Pedro Hernan Riederer, Ingo Negroni, Elisa Desguerre, Isabelle Veras, Mariana Yada, Erica Allenbach, Yves Benveniste, Olivier Voit, Thomas Mouly, Vincent Barbosa, Suse Dayse Silva Butler-Browne, Gillian Savino, Wilson |
| author_role |
author |
| author2 |
Carvalho, Luciana Rodrigues Araujo, Alexandra Prufer De Queiroz Campos Mello, Wallace De Ribeiro, Márcia Gonçalves Cunha, Maria Do Carmo Soares Alves Cabello, Pedro Hernan Riederer, Ingo Negroni, Elisa Desguerre, Isabelle Veras, Mariana Yada, Erica Allenbach, Yves Benveniste, Olivier Voit, Thomas Mouly, Vincent Barbosa, Suse Dayse Silva Butler-Browne, Gillian Savino, Wilson |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mariz, Fernanda Pinto Carvalho, Luciana Rodrigues Araujo, Alexandra Prufer De Queiroz Campos Mello, Wallace De Ribeiro, Márcia Gonçalves Cunha, Maria Do Carmo Soares Alves Cabello, Pedro Hernan Riederer, Ingo Negroni, Elisa Desguerre, Isabelle Veras, Mariana Yada, Erica Allenbach, Yves Benveniste, Olivier Voit, Thomas Mouly, Vincent Barbosa, Suse Dayse Silva Butler-Browne, Gillian Savino, Wilson |
| dc.subject.other.pt_BR.fl_str_mv |
Biomarcador preditivo |
| topic |
Biomarcador preditivo Duchenne muscular dystrophy Inflammation CD49d T lymphocytes Predictive biomarker Immunotherapy Distrofia Muscular de Duchenne Inflamação Linfócitos T Imunoterapia |
| dc.subject.en.pt_BR.fl_str_mv |
Duchenne muscular dystrophy Inflammation CD49d T lymphocytes Predictive biomarker Immunotherapy |
| dc.subject.decs.pt_BR.fl_str_mv |
Distrofia Muscular de Duchenne Inflamação Linfócitos T Imunoterapia |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil / Sorbonne Universités, UPMC Univ Paris 06, UM76, INSERM U974, CNRS FRE3617, Center for Research in Myology, 47 boulevard de l’Hopital, Paris 75651, France. |
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2015 |
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2015 |
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2016-03-08T14:27:12Z |
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2016-03-08T14:27:12Z |
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info:eu-repo/semantics/publishedVersion |
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MARIZ, Fernanda Pinto; et al. CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy. Skeletal Muscle, v.5:45, 10p, Dec. 2015. |
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https://www.arca.fiocruz.br/handle/icict/13053 |
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2044-5040 |
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10.1186/s13395-015-0066-2 |
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MARIZ, Fernanda Pinto; et al. CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy. Skeletal Muscle, v.5:45, 10p, Dec. 2015. 2044-5040 10.1186/s13395-015-0066-2 |
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