Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition

Detalhes bibliográficos
Autor(a) principal: Peixoto, Christina Alves
Data de Publicação: 2015
Outros Autores: Nunes, Ana Karolina Santana, Garcia-Osta, Ana
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20991
Resumo: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
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spelling Peixoto, Christina AlvesNunes, Ana Karolina SantanaGarcia-Osta, Ana2017-09-12T19:35:23Z2017-09-12T19:35:23Z2015PEIXOTO, C. A.; NUNES, A. K. S.; GARCIA-OSTA, A. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation, v. 2015, p. 940207, 20151466-1861https://www.arca.fiocruz.br/handle/icict/2099110.1155/2015/940207porCogniçãoDegeneração NeuralNeuroimunomodulaçãoInibidores da Fosfodiesterase 5CognitionNerve DegenerationNeuroimmunomodulationPhosphodiesterase 5 InhibitorsAnimalsBlood-Brain BarrierHumansMiceNeurogliaNeurogenesisNeuroprotective AgentsNucleotides, CyclicCogniçãoDegeneração NeuralNeuroimunomodulaçãoInibidores da Fosfodiesterase 5AnimaisBarreira HematoencefálicaHumanosCamundongosNeurogêneseNeurogliaFármacos NeuroprotetoresNucleotídeos CíclicosPhosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognitioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilPhosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a potential therapeutic strategy for neuroinflammatory, neurodegenerative, and memory loss diseases. Mechanistically, PDE5-Is produce an anti-inflammatory and neuroprotection effect by increasing expression of nitric oxide synthases and accumulation of cGMP and activating protein kinase G (PKG), the signaling pathway of which is thought to play an important role in the development of several neurodiseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The aim of this paper was to review present knowledge of the signaling pathways that underlie the use of PDE5-Is in neuroinflammation, neurogenesis, learning, and memory.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20991/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL26770022 2015 pei-pho.oa.pdf26770022 2015 pei-pho.oa.pdfapplication/pdf711489https://www.arca.fiocruz.br/bitstream/icict/20991/2/26770022%202015%20pei-pho.oa.pdf639d778eed18409940028659a76ea9faMD52TEXT26770022 2015 pei-pho.oa.pdf.txt26770022 2015 pei-pho.oa.pdf.txtExtracted texttext/plain110163https://www.arca.fiocruz.br/bitstream/icict/20991/3/26770022%202015%20pei-pho.oa.pdf.txt40d736e202e03c82e41700ca66be1d21MD53icict/209912018-08-15 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dc.title.pt_BR.fl_str_mv Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
title Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
spellingShingle Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
Peixoto, Christina Alves
Cognição
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Cognition
Nerve Degeneration
Neuroimmunomodulation
Phosphodiesterase 5 Inhibitors
Animals
Blood-Brain Barrier
Humans
Mice
Neuroglia
Neurogenesis
Neuroprotective Agents
Nucleotides, Cyclic
Cognição
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Animais
Barreira Hematoencefálica
Humanos
Camundongos
Neurogênese
Neuroglia
Fármacos Neuroprotetores
Nucleotídeos Cíclicos
title_short Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
title_full Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
title_fullStr Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
title_full_unstemmed Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
title_sort Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
author Peixoto, Christina Alves
author_facet Peixoto, Christina Alves
Nunes, Ana Karolina Santana
Garcia-Osta, Ana
author_role author
author2 Nunes, Ana Karolina Santana
Garcia-Osta, Ana
author2_role author
author
dc.contributor.author.fl_str_mv Peixoto, Christina Alves
Nunes, Ana Karolina Santana
Garcia-Osta, Ana
dc.subject.other.pt_BR.fl_str_mv Cognição
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
topic Cognição
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Cognition
Nerve Degeneration
Neuroimmunomodulation
Phosphodiesterase 5 Inhibitors
Animals
Blood-Brain Barrier
Humans
Mice
Neuroglia
Neurogenesis
Neuroprotective Agents
Nucleotides, Cyclic
Cognição
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Animais
Barreira Hematoencefálica
Humanos
Camundongos
Neurogênese
Neuroglia
Fármacos Neuroprotetores
Nucleotídeos Cíclicos
dc.subject.en.pt_BR.fl_str_mv Cognition
Nerve Degeneration
Neuroimmunomodulation
Phosphodiesterase 5 Inhibitors
Animals
Blood-Brain Barrier
Humans
Mice
Neuroglia
Neurogenesis
Neuroprotective Agents
Nucleotides, Cyclic
dc.subject.decs.pt_BR.fl_str_mv Cognição
Degeneração Neural
Neuroimunomodulação
Inibidores da Fosfodiesterase 5
Animais
Barreira Hematoencefálica
Humanos
Camundongos
Neurogênese
Neuroglia
Fármacos Neuroprotetores
Nucleotídeos Cíclicos
description Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-09-12T19:35:23Z
dc.date.available.fl_str_mv 2017-09-12T19:35:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PEIXOTO, C. A.; NUNES, A. K. S.; GARCIA-OSTA, A. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation, v. 2015, p. 940207, 2015
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20991
dc.identifier.issn.pt_BR.fl_str_mv 1466-1861
dc.identifier.doi.none.fl_str_mv 10.1155/2015/940207
identifier_str_mv PEIXOTO, C. A.; NUNES, A. K. S.; GARCIA-OSTA, A. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation, v. 2015, p. 940207, 2015
1466-1861
10.1155/2015/940207
url https://www.arca.fiocruz.br/handle/icict/20991
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/20991/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/20991/3/26770022%202015%20pei-pho.oa.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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