Action of colchicine on hepatic schistosomal granuloma.

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 1990
Outros Autores: Medeiros, Maria Vilma P, Carmo, Theomira Mauadie de Azevedo, Guerret, Sylviane Stocker
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5717
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de AraújoMedeiros, Maria Vilma PCarmo, Theomira Mauadie de AzevedoGuerret, Sylviane Stocker2012-10-23T16:45:45Z2012-10-23T16:45:45Z1990ANDRADE, Z.A. et al. Action of colchicine on hepatic schistosomal granuloma. Memórias do Instituto Oswaldo Cruz, v. 85, n. 1, p. 79-85, jan.-mar. 1990.0074-0276https://www.arca.fiocruz.br/handle/icict/5717engAction of colchicine on hepatic schistosomal granuloma.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAmorphous material and altered collagen fragments within dilated secretory vesicles and cisternae of fibroblast cytoplasm were the main ultrastructural changes seen in hepatic periovular granulomas formed in mice infected with Schistosoma mansoni and treated with colchicine. Despite promoting ultrastructural changes in the fibroblasts found in hepatic periovular granulomas, colchicine administration to infected mice did not significantly change the light microscopic appearance of the hepatic schistosomal lesions, did not diminish the amount of total hepatic collagen, and did not change the collagen isotypes in the granulomas, as observed after a comparative study with non-colchicine treated infected control mice. When administered to mice two weeks after curative treatment of schistosomiasis with praziquantel, colchicine did not seem to increase extracellular collagen degradation or to induce a more rapid resorption of hepatic periovular granulomas, although still promoting ultrastructural alterations in fibroblasts.Schistosoma mansoniFibrosisColchicinePeriovular granulomaColchicina/uso terapêuticoGranuloma/quimioterapiaHepatopatias Parasitárias/quimioterapiaEsquistossomose mansoni/quimioterapiaAnimaisColágeno/metabolismoFemininoGranuloma/patologiaFígado/ultraestruturaHepatopatias Parasitárias/patologiaMasculinoCamundongosMicroscopia EletrônicaEsquistossomose mansoni/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA Action of colchicine on ....pdfAndrade ZA Action of colchicine on ....pdfapplication/pdf620251https://www.arca.fiocruz.br/bitstream/icict/5717/1/Andrade%20ZA%20Action%20of%20colchicine%20on%20....pdfe885f572b54948d6a57cd79816dd2716MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5717/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA Action of colchicine on ....pdf.txtAndrade ZA Action of colchicine on ....pdf.txtExtracted texttext/plain7https://www.arca.fiocruz.br/bitstream/icict/5717/5/Andrade%20ZA%20Action%20of%20colchicine%20on%20....pdf.txt212b0306580d4f0044d18f9a3edcc832MD55THUMBNAILAndrade ZA Action of colchicine on ....pdf.jpgAndrade ZA Action of colchicine on ....pdf.jpgGenerated Thumbnailimage/jpeg2609https://www.arca.fiocruz.br/bitstream/icict/5717/4/Andrade%20ZA%20Action%20of%20colchicine%20on%20....pdf.jpga8035a26710afe106d594b44e1869655MD54icict/57172023-03-15 14:32:55.35oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Action of colchicine on hepatic schistosomal granuloma.
title Action of colchicine on hepatic schistosomal granuloma.
spellingShingle Action of colchicine on hepatic schistosomal granuloma.
Andrade, Zilton de Araújo
Schistosoma mansoni
Fibrosis
Colchicine
Periovular granuloma
Colchicina/uso terapêutico
Granuloma/quimioterapia
Hepatopatias Parasitárias/quimioterapia
Esquistossomose mansoni/quimioterapia
Animais
Colágeno/metabolismo
Feminino
Granuloma/patologia
Fígado/ultraestrutura
Hepatopatias Parasitárias/patologia
Masculino
Camundongos
Microscopia Eletrônica
Esquistossomose mansoni/patologia
title_short Action of colchicine on hepatic schistosomal granuloma.
title_full Action of colchicine on hepatic schistosomal granuloma.
title_fullStr Action of colchicine on hepatic schistosomal granuloma.
title_full_unstemmed Action of colchicine on hepatic schistosomal granuloma.
title_sort Action of colchicine on hepatic schistosomal granuloma.
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Medeiros, Maria Vilma P
Carmo, Theomira Mauadie de Azevedo
Guerret, Sylviane Stocker
author_role author
author2 Medeiros, Maria Vilma P
Carmo, Theomira Mauadie de Azevedo
Guerret, Sylviane Stocker
author2_role author
author
author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Medeiros, Maria Vilma P
Carmo, Theomira Mauadie de Azevedo
Guerret, Sylviane Stocker
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
Fibrosis
Colchicine
Periovular granuloma
topic Schistosoma mansoni
Fibrosis
Colchicine
Periovular granuloma
Colchicina/uso terapêutico
Granuloma/quimioterapia
Hepatopatias Parasitárias/quimioterapia
Esquistossomose mansoni/quimioterapia
Animais
Colágeno/metabolismo
Feminino
Granuloma/patologia
Fígado/ultraestrutura
Hepatopatias Parasitárias/patologia
Masculino
Camundongos
Microscopia Eletrônica
Esquistossomose mansoni/patologia
dc.subject.decs.pt_BR.fl_str_mv Colchicina/uso terapêutico
Granuloma/quimioterapia
Hepatopatias Parasitárias/quimioterapia
Esquistossomose mansoni/quimioterapia
Animais
Colágeno/metabolismo
Feminino
Granuloma/patologia
Fígado/ultraestrutura
Hepatopatias Parasitárias/patologia
Masculino
Camundongos
Microscopia Eletrônica
Esquistossomose mansoni/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 1990
dc.date.issued.fl_str_mv 1990
dc.date.accessioned.fl_str_mv 2012-10-23T16:45:45Z
dc.date.available.fl_str_mv 2012-10-23T16:45:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Z.A. et al. Action of colchicine on hepatic schistosomal granuloma. Memórias do Instituto Oswaldo Cruz, v. 85, n. 1, p. 79-85, jan.-mar. 1990.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5717
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv ANDRADE, Z.A. et al. Action of colchicine on hepatic schistosomal granuloma. Memórias do Instituto Oswaldo Cruz, v. 85, n. 1, p. 79-85, jan.-mar. 1990.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5717
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