Significance of schistosomal granuloma modulation

Detalhes bibliográficos
Autor(a) principal: Silva, Luciana Menezes da
Data de Publicação: 2000
Outros Autores: Fernandes, André L. M, Barbosa Junior, Aryon de Almeida, Oliveira, Irismar Reis de, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5639
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Silva, Luciana Menezes daFernandes, André L. MBarbosa Junior, Aryon de AlmeidaOliveira, Irismar Reis deAndrade, Zilton de Araújo2012-10-03T21:15:58Z2012-10-03T21:15:58Z2000SILVA, L.M. et al. Significance of schistosomal granuloma modulation. Memórias do Instituto Oswaldo Cruz, v. 95, n. 3, p.353-61, may-jun. 2000.0074-0276https://www.arca.fiocruz.br/handle/icict/5639engSignificance of schistosomal granuloma modulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHepatic Schistosoma mansoni periovular granulomas undergo changes in size, cellular composition and appearance with time. This phenomenon, known as "immunological modulation", has been thought to reflect host immunological status. However, as modulation has not been observed outside the liver, participation of local factors, hitherto little considered, seems crucial. Components of the extracellular matrix of periovular granulomas of the mouse were particularly studied in three different organs (liver, lung and intestine) and during three periods of infection time (acute, intermediate and chronic) by means of histological, biochemical and immunofluorescence techniques, while quantitative data were evaluated by computerized morphometry, in order to investigate participation of local factors in granuloma modulation. Results confirmed modulation as a exclusively hepatic phenomenon, since pulmonary and intestinal granulomas, formed around mature eggs, did not change size and appearance with time. The matricial components which were investigated (Type I, III and IV collagens, fibronectin, laminin, proteoglycans and elastin) were found in all granulomas and in all organs examined. However, their presence was much more prominent in the liver. Elastin was only found in hepatic granulomas of chronic infection. The large amount of extracellular matrix components found in hepatic granulomas was the main change responsible for the morphological aspects of modulation. Therefore, the peculiar environment of the liver ultimately determines the changes identified in schistosomal granuloma as "modulation".ModulationGranulomaShistosomiasisExtracellular matrixGranuloma/patologiaEnteropatias Parasitárias/patologiaHepatopatias Parasitárias/patologiaPneumopatias Parasitárias/patologiaSchistosoma mansoni/imunologiaEsquistossomose mansoni/patologiaAnimaisMatriz ExtracelularFemininoGranuloma/imunologiaGranuloma/parasitologiaEnteropatias Parasitárias/imunologiaEnteropatias Parasitárias/parasitologiaHepatopatias Parasitárias/imunologiaHepatopatias Parasitárias/parasitologiaPneumopatias Parasitárias/imunologiaMasculinoCamundongosContagem de Ovos de ParasitasEsquistossomose mansoni/imunologiaEsquistossomose mansoni/parasitologiaFatores de Tempoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSilva LM Significance of schistosomal ....pdfSilva LM Significance of schistosomal ....pdfapplication/pdf1190522https://www.arca.fiocruz.br/bitstream/icict/5639/1/Silva%20LM%20Significance%20of%20schistosomal%20%20....pdf97ca2c410fe83d6b2fbad46cac9f2e12MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5639/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTSilva LM Significance of schistosomal ....pdf.txtSilva LM Significance of schistosomal ....pdf.txtExtracted texttext/plain24698https://www.arca.fiocruz.br/bitstream/icict/5639/5/Silva%20LM%20Significance%20of%20schistosomal%20%20....pdf.txt405968cfe83e45b4adf58381a95e43a9MD55THUMBNAILSilva LM Significance of schistosomal ....pdf.jpgSilva LM Significance of schistosomal ....pdf.jpgGenerated Thumbnailimage/jpeg2230https://www.arca.fiocruz.br/bitstream/icict/5639/4/Silva%20LM%20Significance%20of%20schistosomal%20%20....pdf.jpg4fc9b0d883d554100fefb5dee7a86304MD54icict/56392023-03-15 14:33:59.958oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Significance of schistosomal granuloma modulation
title Significance of schistosomal granuloma modulation
spellingShingle Significance of schistosomal granuloma modulation
Silva, Luciana Menezes da
Modulation
Granuloma
Shistosomiasis
Extracellular matrix
Granuloma/patologia
Enteropatias Parasitárias/patologia
Hepatopatias Parasitárias/patologia
Pneumopatias Parasitárias/patologia
Schistosoma mansoni/imunologia
Esquistossomose mansoni/patologia
Animais
Matriz Extracelular
Feminino
Granuloma/imunologia
Granuloma/parasitologia
Enteropatias Parasitárias/imunologia
Enteropatias Parasitárias/parasitologia
Hepatopatias Parasitárias/imunologia
Hepatopatias Parasitárias/parasitologia
Pneumopatias Parasitárias/imunologia
Masculino
Camundongos
Contagem de Ovos de Parasitas
Esquistossomose mansoni/imunologia
Esquistossomose mansoni/parasitologia
Fatores de Tempo
title_short Significance of schistosomal granuloma modulation
title_full Significance of schistosomal granuloma modulation
title_fullStr Significance of schistosomal granuloma modulation
title_full_unstemmed Significance of schistosomal granuloma modulation
title_sort Significance of schistosomal granuloma modulation
author Silva, Luciana Menezes da
author_facet Silva, Luciana Menezes da
Fernandes, André L. M
Barbosa Junior, Aryon de Almeida
Oliveira, Irismar Reis de
Andrade, Zilton de Araújo
author_role author
author2 Fernandes, André L. M
Barbosa Junior, Aryon de Almeida
Oliveira, Irismar Reis de
Andrade, Zilton de Araújo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Luciana Menezes da
Fernandes, André L. M
Barbosa Junior, Aryon de Almeida
Oliveira, Irismar Reis de
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Modulation
Granuloma
Shistosomiasis
Extracellular matrix
topic Modulation
Granuloma
Shistosomiasis
Extracellular matrix
Granuloma/patologia
Enteropatias Parasitárias/patologia
Hepatopatias Parasitárias/patologia
Pneumopatias Parasitárias/patologia
Schistosoma mansoni/imunologia
Esquistossomose mansoni/patologia
Animais
Matriz Extracelular
Feminino
Granuloma/imunologia
Granuloma/parasitologia
Enteropatias Parasitárias/imunologia
Enteropatias Parasitárias/parasitologia
Hepatopatias Parasitárias/imunologia
Hepatopatias Parasitárias/parasitologia
Pneumopatias Parasitárias/imunologia
Masculino
Camundongos
Contagem de Ovos de Parasitas
Esquistossomose mansoni/imunologia
Esquistossomose mansoni/parasitologia
Fatores de Tempo
dc.subject.decs.pt_BR.fl_str_mv Granuloma/patologia
Enteropatias Parasitárias/patologia
Hepatopatias Parasitárias/patologia
Pneumopatias Parasitárias/patologia
Schistosoma mansoni/imunologia
Esquistossomose mansoni/patologia
Animais
Matriz Extracelular
Feminino
Granuloma/imunologia
Granuloma/parasitologia
Enteropatias Parasitárias/imunologia
Enteropatias Parasitárias/parasitologia
Hepatopatias Parasitárias/imunologia
Hepatopatias Parasitárias/parasitologia
Pneumopatias Parasitárias/imunologia
Masculino
Camundongos
Contagem de Ovos de Parasitas
Esquistossomose mansoni/imunologia
Esquistossomose mansoni/parasitologia
Fatores de Tempo
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2012-10-03T21:15:58Z
dc.date.available.fl_str_mv 2012-10-03T21:15:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, L.M. et al. Significance of schistosomal granuloma modulation. Memórias do Instituto Oswaldo Cruz, v. 95, n. 3, p.353-61, may-jun. 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5639
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv SILVA, L.M. et al. Significance of schistosomal granuloma modulation. Memórias do Instituto Oswaldo Cruz, v. 95, n. 3, p.353-61, may-jun. 2000.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/5639
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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