Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein

Detalhes bibliográficos
Autor(a) principal: Song, Hao
Data de Publicação: 2019
Outros Autores: Zhao, Zhennan, Chai, Yan, Jin, Xiyue, Li, Changyao, Yuan, Fei, Liu, Sheng, Gao, Zhengrong, Wang, Haiyuan, Song, Jian, Vazquez, Leonardo, Zhang, Yanfang, Tan, Shuguang, Morel, Carlos M., Yan, Jinghua, Shi, Yi, Qi, Jianxun, Gao, Feng, Gao, George F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59386
Resumo: Research Network of Immunity and Health. Beijing Institutes of Life Science. Chinese Academy of Sciences. Beijing, China.
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spelling Song, HaoZhao, ZhennanChai, YanJin, XiyueLi, ChangyaoYuan, FeiLiu, ShengGao, ZhengrongWang, HaiyuanSong, JianVazquez, LeonardoZhang, YanfangTan, ShuguangMorel, Carlos M.Yan, JinghuaShi, YiQi, JianxunGao, FengGao, George F.2023-07-03T22:44:54Z2023-07-03T22:44:54Z2019SONG, Hao et al. Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein. Cell, v. 177, n. 7, p. 1714-1724, Jun. 2019.0092-8674https://www.arca.fiocruz.br/handle/icict/5938610.1016/J.CELL.2019.04.0081097-4172engMIT PressAnimalsChikungunya virusChlorocebus aethiopsHEK293 CellsHumansMembrane ProteinsProtein DomainsVero CellsViral Envelope ProteinsVirus InternalizationAdhesion moleculeArthritogenic alphavirusChikungunya virusMXRA8Recepor bindingVirus entryHuman monoclonal-antibodiesCrystal-structureContactRevealsDicamEntryHEK293 CellsMolecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Proteininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleResearch Network of Immunity and Health. Beijing Institutes of Life Science. Chinese Academy of Sciences. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China / Savaid Medical School. University of Chinese Academy of Sciences. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China / School of Life Sciences. University of Science and Technology of China. Hefei, China.College of Veterinary Medicine. China Agricultural University. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China / School of Life Sciences. University of Science and Technology of China. Hefei, China.Kunming Institute of Zoology. Chinese Academy of Sciences. Kunming, China.College of Animal Sciences and Technology. Guangxi University. Nanning, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute of Science and Technology for Innovation on Diseases of Neglected Populations. Rio de Janeiro, RJ, Brazil.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China. / Savaid Medical School. University of Chinese Academy of Sciences. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China.Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute of Science and Technology for Innovation on Diseases of Neglected Populations. Rio de Janeiro, RJ, Brazil.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China / Savaid Medical School. University of Chinese Academy of Sciences. Beijing, China / CAS Center for Influenza Research and Early-warning. Chinese Academy of Sciences. Beijing, China.CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China / Savaid Medical School. University of Chinese Academy of Sciences. Beijing, China.Tianjin Institute of Industrial Biotechnology. Chinese Academy of Sciences. Tianjin, China / Institute of Genetics and Developmental Biology. Chinese Academy of Sciences. Beijing, China.Research Network of Immunity and Health. Beijing Institutes of Life Science. Chinese Academy of Sciences. Beijing, China / CAS Key Laboratory of Pathogenic Microbiology and Immunology. Institute of Microbiology. Chinese Academy of Sciences. Beijing, China / Savaid Medical School. University of Chinese Academy of Sciences. Beijing, China / School of Life Sciences. University of Science and Technology of China. Hefei, China / CAS Center for Influenza Research and Early-warning. Chinese Academy of Sciences. Beijing, China / Tianjin Institute of Industrial Biotechnology. Chinese Academy of Sciences. Tianjin, China / National Institute for Viral Disease Control and Prevention. Chinese Center for Disease Control and Prevention. Beijing, China.Arthritogenic alphaviruses, such as Chikungunya virus (CHIKV), cause severe and debilitating rheumatic diseases worldwide, resulting in severe morbidity and economic costs. Recently, MXRA8 was reported as an entry receptor. Here, we present the crystal structures of the mouse MXRA8, human MXRA8 in complex with the CHIKV E protein, and the cryo-electron microscopy structure of human MXRA8 and CHIKV virus-like particle. MXRA8 has two Ig-like domains with unique structural topologies. This receptor binds in the "canyon" between two protomers of the E spike on the surface of the virion. The atomic details at the interface between the two binding entities reveal that both the two domains and the hinge region of MXRA8 are involved in interaction with CHIKV E1-E2 residues from two protomers. Notably, the stalk region of MXRA8 is critical for CHIKV virus entry. This finding provides important information regarding the development of therapeutic countermeasures against those arthritogenic alphaviruses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59386/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINAL10.1016_j.cell.2019.04.008.pdfapplication/pdf12148469https://www.arca.fiocruz.br/bitstream/icict/59386/2/10.1016_j.cell.2019.04.008.pdf9ab401903a2ce5faff6f937edc670351MD52icict/593862023-07-03 20:42:19.844oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-03T23:42:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
title Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
spellingShingle Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
Song, Hao
Animals
Chikungunya virus
Chlorocebus aethiops
HEK293 Cells
Humans
Membrane Proteins
Protein Domains
Vero Cells
Viral Envelope Proteins
Virus Internalization
Adhesion molecule
Arthritogenic alphavirus
Chikungunya virus
MXRA8
Recepor binding
Virus entry
Human monoclonal-antibodies
Crystal-structure
Contact
Reveals
Dicam
Entry
HEK293 Cells
title_short Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
title_full Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
title_fullStr Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
title_full_unstemmed Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
title_sort Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
author Song, Hao
author_facet Song, Hao
Zhao, Zhennan
Chai, Yan
Jin, Xiyue
Li, Changyao
Yuan, Fei
Liu, Sheng
Gao, Zhengrong
Wang, Haiyuan
Song, Jian
Vazquez, Leonardo
Zhang, Yanfang
Tan, Shuguang
Morel, Carlos M.
Yan, Jinghua
Shi, Yi
Qi, Jianxun
Gao, Feng
Gao, George F.
author_role author
author2 Zhao, Zhennan
Chai, Yan
Jin, Xiyue
Li, Changyao
Yuan, Fei
Liu, Sheng
Gao, Zhengrong
Wang, Haiyuan
Song, Jian
Vazquez, Leonardo
Zhang, Yanfang
Tan, Shuguang
Morel, Carlos M.
Yan, Jinghua
Shi, Yi
Qi, Jianxun
Gao, Feng
Gao, George F.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Song, Hao
Zhao, Zhennan
Chai, Yan
Jin, Xiyue
Li, Changyao
Yuan, Fei
Liu, Sheng
Gao, Zhengrong
Wang, Haiyuan
Song, Jian
Vazquez, Leonardo
Zhang, Yanfang
Tan, Shuguang
Morel, Carlos M.
Yan, Jinghua
Shi, Yi
Qi, Jianxun
Gao, Feng
Gao, George F.
dc.subject.mesh.en_US.fl_str_mv Animals
Chikungunya virus
Chlorocebus aethiops
HEK293 Cells
Humans
Membrane Proteins
Protein Domains
Vero Cells
Viral Envelope Proteins
Virus Internalization
topic Animals
Chikungunya virus
Chlorocebus aethiops
HEK293 Cells
Humans
Membrane Proteins
Protein Domains
Vero Cells
Viral Envelope Proteins
Virus Internalization
Adhesion molecule
Arthritogenic alphavirus
Chikungunya virus
MXRA8
Recepor binding
Virus entry
Human monoclonal-antibodies
Crystal-structure
Contact
Reveals
Dicam
Entry
HEK293 Cells
dc.subject.en.en_US.fl_str_mv Adhesion molecule
Arthritogenic alphavirus
Chikungunya virus
MXRA8
Recepor binding
Virus entry
Human monoclonal-antibodies
Crystal-structure
Contact
Reveals
Dicam
Entry
dc.subject.en.none.fl_str_mv HEK293 Cells
description Research Network of Immunity and Health. Beijing Institutes of Life Science. Chinese Academy of Sciences. Beijing, China.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2023-07-03T22:44:54Z
dc.date.available.fl_str_mv 2023-07-03T22:44:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SONG, Hao et al. Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein. Cell, v. 177, n. 7, p. 1714-1724, Jun. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59386
dc.identifier.issn.en_US.fl_str_mv 0092-8674
dc.identifier.doi.none.fl_str_mv 10.1016/J.CELL.2019.04.008
dc.identifier.eissn.none.fl_str_mv 1097-4172
identifier_str_mv SONG, Hao et al. Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein. Cell, v. 177, n. 7, p. 1714-1724, Jun. 2019.
0092-8674
10.1016/J.CELL.2019.04.008
1097-4172
url https://www.arca.fiocruz.br/handle/icict/59386
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MIT Press
publisher.none.fl_str_mv MIT Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59386/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/59386/2/10.1016_j.cell.2019.04.008.pdf
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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