Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi

Detalhes bibliográficos
Autor(a) principal: Aguirre, Kezia L. H.
Data de Publicação: 2009
Outros Autores: Alves, José B, Silva, Gerluza Aparecida Borges, Cardoso, Jarbas E, Murta, Silvane Maria Fonseca, Ferreira, Anderson J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58758
https://doi.org/10.1590/S0074-02762009000500009
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil
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spelling Aguirre, Kezia L. H.Alves, José BSilva, Gerluza Aparecida BorgesCardoso, Jarbas EMurta, Silvane Maria FonsecaFerreira, Anderson J2023-05-26T18:33:23Z2023-05-26T18:33:23Z2009AGUIRRE, Kezia LH et al. Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi. Mem. Inst. Oswaldo Cruz, v. 104, n. 5, p. 715-719, 2009. doi.org/10.1590/S0074-027620090005000090074-0276https://www.arca.fiocruz.br/handle/icict/58758https://doi.org/10.1590/S0074-02762009000500009engMinistério da SaúdeEpidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil/Universidade de Uberaba. Laboratório de Biopatologia e Biologia Molecular. Uberaba, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, BrasilIt has been demonstrated that parotid glands of rats infected with Trypanosoma cruzi present severe histological alterations; changes include reduction in density and volume of the acini and duct systems and an increase in connective tissue. We evaluated the association between morphological changes in parotid glands, circulating testosterone levels and epidermal growth factor receptor (EGF-R) expression in experimental Chagas disease in rats. Animals at 18 days of infection (acute phase) showed a significant decrease in body weight, serum testosterone levels and EGF-R expression in the parotid gland compared with a control group. Since decreases in body weight could lead to a reduction in circulating testosterone concentration, we believe that the reduction in EGF-R expression in parotid glands of infected rats is due to alterations in testosterone levels and atrophy of parotid glands is caused by changes in EGF-R expression. Additionally, at 50 days (chronic phase) of infection parotid glands showed a normal histological aspect likely due to the normalization of the body weight. These findings suggest that the testosterone-EGF-R axis is involved in the histological changesparotid glandshistological alterationsChagas diseasetestosteroneEGF-receptorinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALindex.pdfindex.pdfapplication/pdf415511https://www.arca.fiocruz.br/bitstream/icict/58758/2/index.pdfd218beb67ba99943f5d2da70e07aa706MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58758/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/587582023-05-26 15:33:24.994oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-26T18:33:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
title Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
spellingShingle Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
Aguirre, Kezia L. H.
parotid glands
histological alterations
Chagas disease
testosterone
EGF-receptor
title_short Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
title_full Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
title_fullStr Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
title_full_unstemmed Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
title_sort Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
author Aguirre, Kezia L. H.
author_facet Aguirre, Kezia L. H.
Alves, José B
Silva, Gerluza Aparecida Borges
Cardoso, Jarbas E
Murta, Silvane Maria Fonseca
Ferreira, Anderson J
author_role author
author2 Alves, José B
Silva, Gerluza Aparecida Borges
Cardoso, Jarbas E
Murta, Silvane Maria Fonseca
Ferreira, Anderson J
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Aguirre, Kezia L. H.
Alves, José B
Silva, Gerluza Aparecida Borges
Cardoso, Jarbas E
Murta, Silvane Maria Fonseca
Ferreira, Anderson J
dc.subject.en.en_US.fl_str_mv parotid glands
histological alterations
Chagas disease
testosterone
EGF-receptor
topic parotid glands
histological alterations
Chagas disease
testosterone
EGF-receptor
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2023-05-26T18:33:23Z
dc.date.available.fl_str_mv 2023-05-26T18:33:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AGUIRRE, Kezia LH et al. Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi. Mem. Inst. Oswaldo Cruz, v. 104, n. 5, p. 715-719, 2009. doi.org/10.1590/S0074-02762009000500009
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58758
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1590/S0074-02762009000500009
identifier_str_mv AGUIRRE, Kezia LH et al. Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi. Mem. Inst. Oswaldo Cruz, v. 104, n. 5, p. 715-719, 2009. doi.org/10.1590/S0074-02762009000500009
0074-0276
url https://www.arca.fiocruz.br/handle/icict/58758
https://doi.org/10.1590/S0074-02762009000500009
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Ministério da Saúde
publisher.none.fl_str_mv Ministério da Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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