Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51871 |
Resumo: | Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Biomédica. Curitiba, PR, Brasil. |
| id |
CRUZ_d27c1b0fbed47c3bb69cd19ace66e4d0 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/51871 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Oliveira, Tiê MenezesBerti, Fernanda Costa BrandãoGasoto, Sidney CarlosSchneider Jr., BertoldoStimamiglio, Marco AugustoBerti, Lucas Freitas2022-03-25T13:42:06Z2022-03-25T13:42:06Z2021OLIVEIRA, Tiê Menezes et al. Calcium phosphate-based bioceramics in the treatment of Osteosarcoma: drug delivery composites and magnetic hyperthermia agents. Frontiers in Medical Technology, v. 3, n. 700266, p. 1–12, 2021.2235-2988https://www.arca.fiocruz.br/handle/icict/5187110.3389/fmedt.2021.700266porFrontiers MediaBiocerâmicaDurapatiteBiocompatible MaterialsDrug Delivery SystemsHyperthermiaOsteosarcomaDurapatitaMateriales BiocompatiblesSistemas de Liberación de MedicamentosHipertermiaOsteosarcomaDurapatiteMatériaux biocompatiblesSystèmes de délivrance de médicamentsHyperthermieOstéosarcomeHidroxiapatitaMateriais BiocompatíveisSistemas de Liberação de MedicamentosHipertermiaOsteossarcomaCalcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Biomédica. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Programa de Pós-Graduação em Genética. Curitiba, PR, Brasil.Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Elétrica e Informática Industrial. Curitiba, PR, Brasil.Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Elétrica e Informática Industrial. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Biomédica. Curitiba, PR, Brasil.The use of biomaterials in medicine is not recent, and in the last few decades, the research and development of biocompatible materials had emerged. Hydroxyapatite (HAp), a calcium phosphate that constitutes a large part of the inorganic composition of human bones and teeth, has been used as an interesting bioceramic material. Among its applications, HAp has been used to carry antitumor drugs, such as doxorubicin, cisplatin, and gemcitabine. Such HAp-based composites have an essential role in anticancer drug delivery systems, including the treatment of osteosarcoma. In addition, the association of this bioceramic with magnetic nanoparticles (MNPs) has also been used as an effective agent of local magnetic hyperthermia. Further, the combined approach of the aforementioned techniques (HAp scaffolds combined with anti-tumor drugs and MNPs) is also an attractive therapeutical alternative. Considering the promising role of the use of bioceramics in modern medicine, we proposed this review, presenting an updated perspective on the use of HAp in the treatment of cancer, especially osteosarcoma. Finally, after giving the current progress in this field, we highlight the urgent need for efforts to provide a better understanding of their potential applications.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/51871/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfmedt-03-700266OK.pdffmedt-03-700266OK.pdfapplication/pdf964009https://www.arca.fiocruz.br/bitstream/icict/51871/2/fmedt-03-700266OK.pdf4d430fd982b8234eebf6fba89b2e9186MD52TEXTfmedt-03-700266OK.pdf.txtfmedt-03-700266OK.pdf.txtExtracted texttext/plain67366https://www.arca.fiocruz.br/bitstream/icict/51871/3/fmedt-03-700266OK.pdf.txtd617fef85f012811a45c66b27f1d8cfbMD53icict/518712022-03-26 02:00:08.185oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-03-26T05:00:08Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents |
| title |
Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents |
| spellingShingle |
Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents Oliveira, Tiê Menezes Biocerâmica Durapatite Biocompatible Materials Drug Delivery Systems Hyperthermia Osteosarcoma Durapatita Materiales Biocompatibles Sistemas de Liberación de Medicamentos Hipertermia Osteosarcoma Durapatite Matériaux biocompatibles Systèmes de délivrance de médicaments Hyperthermie Ostéosarcome Hidroxiapatita Materiais Biocompatíveis Sistemas de Liberação de Medicamentos Hipertermia Osteossarcoma |
| title_short |
Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents |
| title_full |
Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents |
| title_fullStr |
Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents |
| title_full_unstemmed |
Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents |
| title_sort |
Calcium phosphate-based bioceramics in the treatment of osteosarcoma: drug delivery composites and magnetic hyperthermia agents |
| author |
Oliveira, Tiê Menezes |
| author_facet |
Oliveira, Tiê Menezes Berti, Fernanda Costa Brandão Gasoto, Sidney Carlos Schneider Jr., Bertoldo Stimamiglio, Marco Augusto Berti, Lucas Freitas |
| author_role |
author |
| author2 |
Berti, Fernanda Costa Brandão Gasoto, Sidney Carlos Schneider Jr., Bertoldo Stimamiglio, Marco Augusto Berti, Lucas Freitas |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Tiê Menezes Berti, Fernanda Costa Brandão Gasoto, Sidney Carlos Schneider Jr., Bertoldo Stimamiglio, Marco Augusto Berti, Lucas Freitas |
| dc.subject.other.pt_BR.fl_str_mv |
Biocerâmica |
| topic |
Biocerâmica Durapatite Biocompatible Materials Drug Delivery Systems Hyperthermia Osteosarcoma Durapatita Materiales Biocompatibles Sistemas de Liberación de Medicamentos Hipertermia Osteosarcoma Durapatite Matériaux biocompatibles Systèmes de délivrance de médicaments Hyperthermie Ostéosarcome Hidroxiapatita Materiais Biocompatíveis Sistemas de Liberação de Medicamentos Hipertermia Osteossarcoma |
| dc.subject.en.pt_BR.fl_str_mv |
Durapatite Biocompatible Materials Drug Delivery Systems Hyperthermia Osteosarcoma |
| dc.subject.es.pt_BR.fl_str_mv |
Durapatita Materiales Biocompatibles Sistemas de Liberación de Medicamentos Hipertermia Osteosarcoma |
| dc.subject.fr.pt_BR.fl_str_mv |
Durapatite Matériaux biocompatibles Systèmes de délivrance de médicaments Hyperthermie Ostéosarcome |
| dc.subject.decs.pt_BR.fl_str_mv |
Hidroxiapatita Materiais Biocompatíveis Sistemas de Liberação de Medicamentos Hipertermia Osteossarcoma |
| description |
Universidade Tecnológica Federal do Paraná. Departamento de Engenharia Mecânica. Programa de Pós-Graduação em Engenharia Biomédica. Curitiba, PR, Brasil. |
| publishDate |
2021 |
| dc.date.issued.fl_str_mv |
2021 |
| dc.date.accessioned.fl_str_mv |
2022-03-25T13:42:06Z |
| dc.date.available.fl_str_mv |
2022-03-25T13:42:06Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
OLIVEIRA, Tiê Menezes et al. Calcium phosphate-based bioceramics in the treatment of Osteosarcoma: drug delivery composites and magnetic hyperthermia agents. Frontiers in Medical Technology, v. 3, n. 700266, p. 1–12, 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/51871 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2235-2988 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmedt.2021.700266 |
| identifier_str_mv |
OLIVEIRA, Tiê Menezes et al. Calcium phosphate-based bioceramics in the treatment of Osteosarcoma: drug delivery composites and magnetic hyperthermia agents. Frontiers in Medical Technology, v. 3, n. 700266, p. 1–12, 2021. 2235-2988 10.3389/fmedt.2021.700266 |
| url |
https://www.arca.fiocruz.br/handle/icict/51871 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/51871/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/51871/2/fmedt-03-700266OK.pdf https://www.arca.fiocruz.br/bitstream/icict/51871/3/fmedt-03-700266OK.pdf.txt |
| bitstream.checksum.fl_str_mv |
783568c2893d2e25a99990b126be1772 4d430fd982b8234eebf6fba89b2e9186 d617fef85f012811a45c66b27f1d8cfb |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008961794736128 |