Diagnostic challenges of single plaque-like lesion paucibacillary leprosy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10188 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Barbieri, Raquel RodriguesSales, Anna MariaIllarramendi Rojas, XimenaMoraes, Milton OzórioNery, José Augusto da CostaMoreira, Suelen Justo MariaSarno, Euzenir NunesMachado, Alice de MirandaBozza, Fernando Augusto2015-05-04T16:52:49Z2015-05-04T16:52:49Z2014BARBIERI, Raquel Rodrigues et al. Diagnostic challenges of single plaque-like lesion paucibacillary leprosy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 7, p. 944-947, 2014.0074-0276https://www.arca.fiocruz.br/handle/icict/1018810.1590/0074-02761402121678-8060engInstituto Oswaldo Cruz, Ministério da SaúdeDiagnostic challenges of single plaque-like lesion paucibacillary leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Medicina Intensiva. Rio de Janeiro, RJ, Brasil.The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP), medium (MP) or low (LP) probability of leprosy or other dermatopathy (OD). Mycobacterium leprae-specific genes were detected using qPCR. The biopsies of 47 out of 57 clinically diagnosed patients who received multidrug therapy were classified as HP/MP, eight of which were qPCR negative. In the LP/OD (n = 19), two out of eight untreated patients showed positive qPCR results. In the absence of typical histopathological features, qPCR may be utilised to aid in final patient diagnosis, thus reducing overtreatment and delay in diagnosis.Leprosy, PaucibacillaryMycobacterium lepraeDiagnosisPolymerase Chain Reaction/statistics & numerical dataHanseníase PaucibacilarMycobacterium lepraeDiagnósticoReação em Cadeia da Polimerase/estatística & dados numéricosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10188/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALDiagnostic challenges of single plaque-like lesion paucibacillary leprosy.pdfDiagnostic challenges of single plaque-like lesion paucibacillary leprosy.pdfapplication/pdf782175https://www.arca.fiocruz.br/bitstream/icict/10188/2/Diagnostic%20challenges%20of%20single%20plaque-like%20lesion%20paucibacillary%20leprosy.pdfc9ec8f5aa5622306c80f92d876fbd0c1MD52TEXTDiagnostic challenges of single plaque-like lesion paucibacillary leprosy.pdf.txtDiagnostic challenges of single plaque-like lesion paucibacillary leprosy.pdf.txtExtracted texttext/plain16689https://www.arca.fiocruz.br/bitstream/icict/10188/3/Diagnostic%20challenges%20of%20single%20plaque-like%20lesion%20paucibacillary%20leprosy.pdf.txt86c5d2ff6221263c67586b28bd66e48aMD53icict/101882023-10-30 22:44:15.92oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-31T01:44:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Diagnostic challenges of single plaque-like lesion paucibacillary leprosy |
| title |
Diagnostic challenges of single plaque-like lesion paucibacillary leprosy |
| spellingShingle |
Diagnostic challenges of single plaque-like lesion paucibacillary leprosy Barbieri, Raquel Rodrigues Leprosy, Paucibacillary Mycobacterium leprae Diagnosis Polymerase Chain Reaction/statistics & numerical data Hanseníase Paucibacilar Mycobacterium leprae Diagnóstico Reação em Cadeia da Polimerase/estatística & dados numéricos |
| title_short |
Diagnostic challenges of single plaque-like lesion paucibacillary leprosy |
| title_full |
Diagnostic challenges of single plaque-like lesion paucibacillary leprosy |
| title_fullStr |
Diagnostic challenges of single plaque-like lesion paucibacillary leprosy |
| title_full_unstemmed |
Diagnostic challenges of single plaque-like lesion paucibacillary leprosy |
| title_sort |
Diagnostic challenges of single plaque-like lesion paucibacillary leprosy |
| author |
Barbieri, Raquel Rodrigues |
| author_facet |
Barbieri, Raquel Rodrigues Sales, Anna Maria Illarramendi Rojas, Ximena Moraes, Milton Ozório Nery, José Augusto da Costa Moreira, Suelen Justo Maria Sarno, Euzenir Nunes Machado, Alice de Miranda Bozza, Fernando Augusto |
| author_role |
author |
| author2 |
Sales, Anna Maria Illarramendi Rojas, Ximena Moraes, Milton Ozório Nery, José Augusto da Costa Moreira, Suelen Justo Maria Sarno, Euzenir Nunes Machado, Alice de Miranda Bozza, Fernando Augusto |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barbieri, Raquel Rodrigues Sales, Anna Maria Illarramendi Rojas, Ximena Moraes, Milton Ozório Nery, José Augusto da Costa Moreira, Suelen Justo Maria Sarno, Euzenir Nunes Machado, Alice de Miranda Bozza, Fernando Augusto |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy, Paucibacillary Mycobacterium leprae Diagnosis Polymerase Chain Reaction/statistics & numerical data |
| topic |
Leprosy, Paucibacillary Mycobacterium leprae Diagnosis Polymerase Chain Reaction/statistics & numerical data Hanseníase Paucibacilar Mycobacterium leprae Diagnóstico Reação em Cadeia da Polimerase/estatística & dados numéricos |
| dc.subject.decs.pt_BR.fl_str_mv |
Hanseníase Paucibacilar Mycobacterium leprae Diagnóstico Reação em Cadeia da Polimerase/estatística & dados numéricos |
| description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2014 |
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2014 |
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2015-05-04T16:52:49Z |
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2015-05-04T16:52:49Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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BARBIERI, Raquel Rodrigues et al. Diagnostic challenges of single plaque-like lesion paucibacillary leprosy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 7, p. 944-947, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10188 |
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0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0074-0276140212 |
| dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
| identifier_str_mv |
BARBIERI, Raquel Rodrigues et al. Diagnostic challenges of single plaque-like lesion paucibacillary leprosy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 7, p. 944-947, 2014. 0074-0276 10.1590/0074-0276140212 1678-8060 |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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