The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response

Detalhes bibliográficos
Autor(a) principal: Gupta, Gaurav
Data de Publicação: 2020
Outros Autores: Mou, Zhirong, Jia, Ping, Sharma, Rohit, Zayats, Romaniya, Viana, Sayonara M., Shan, Lianyu, Barral, Aldina Maria Prado, Oliveira, Viviane Sampaio Boaventura de, Murooka, Thomas T., Gounni, Abdel Soussi, Oliveira, Camila Indiani de, Uzonna, ,Jude E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46042
Resumo: Canadian Institutes of Health Research (CIHR) and Research Manitoba.
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spelling Gupta, GauravMou, ZhirongJia, PingSharma, RohitZayats, RomaniyaViana, Sayonara M.Shan, LianyuBarral, Aldina Maria PradoOliveira, Viviane Sampaio Boaventura deMurooka, Thomas T.Gounni, Abdel SoussiOliveira, Camila Indiani deUzonna, ,Jude E.2021-02-11T13:47:19Z2021-02-11T13:47:19Z2020GUPTA, Gaurav et al. The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response. Cell Reports, 2020.2211-1247https://www.arca.fiocruz.br/handle/icict/4604210.1016/j.celrep.2020.108513Canadian Institutes of Health Research (CIHR) and Research Manitoba.University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada / NIIT University. Rajasthan, India.University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada.University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada.Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil.University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada.Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil.University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada.Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil.University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada.University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada.Fundação Oswaldo Cruz, Instituto de Gonçalo Moniz. Salvador, BA, Brasil.University of Manitoba. Rady Faculty of Health Sciences. Max Rady College of Medicine. Department of Immunology. Winnipeg, MB, Canada.The long pentraxin 3 (PTX3) plays a critical role in inflammation, tissue repair, andwound healing.Here,weshow that PTX3 regulates disease pathogenesis in cutaneous leishmaniasis (CL). PTX3 expression increases in skin lesions in patients and mice during CL, with higher expression correlating with severe disease. PTX3-deficient (PTX3 / ) mice are highly resistant to L. major and L. braziliensis infections. This enhanced resistance is associated with increases in Th17 and IL-17A responses. The neutralization of IL-17A abolishes this enhanced resistance, while rPTX3 treatment results in decrease in Th17 and IL-17A responses and increases susceptibility. PTX3 / CD4+ T cells display increased differentiation to Th17 and expression of Th17-specific transcription factors. The addition of rPTX3 suppresses the expression of Th17 transcription factors, Th17 differentiation, and IL-17A production by CD4+ T cells from PTX3 / mice. Collectively, our results show that PTX3 contributes to the pathogenesis of CL by negatively regulating Th17 and IL-17A responses.engCell PressLeishmaniose cutâneaPeleInfecçõesCamundongosPatogênese HomeopáticaCutaneous LeishmaniasisSkinInfectionsMicePathogenesis, HomeopathicThe Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46042/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALGupta Gaurav Long pentraxin....pdfGupta Gaurav Long pentraxin....pdfapplication/pdf3993283https://www.arca.fiocruz.br/bitstream/icict/46042/2/Gupta%20Gaurav%20Long%20pentraxin....pdf48a76af6571a039567f3b408c6ac13cbMD52TEXTGupta Gaurav Long pentraxin....pdf.txtGupta Gaurav Long pentraxin....pdf.txtExtracted texttext/plain87169https://www.arca.fiocruz.br/bitstream/icict/46042/3/Gupta%20Gaurav%20Long%20pentraxin....pdf.txt268b7707edbd494d9f2ec435392fb396MD53icict/460422023-03-15 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dc.title.pt_BR.fl_str_mv The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
title The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
spellingShingle The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
Gupta, Gaurav
Leishmaniose cutânea
Pele
Infecções
Camundongos
Patogênese Homeopática
Cutaneous Leishmaniasis
Skin
Infections
Mice
Pathogenesis, Homeopathic
title_short The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
title_full The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
title_fullStr The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
title_full_unstemmed The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
title_sort The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response
author Gupta, Gaurav
author_facet Gupta, Gaurav
Mou, Zhirong
Jia, Ping
Sharma, Rohit
Zayats, Romaniya
Viana, Sayonara M.
Shan, Lianyu
Barral, Aldina Maria Prado
Oliveira, Viviane Sampaio Boaventura de
Murooka, Thomas T.
Gounni, Abdel Soussi
Oliveira, Camila Indiani de
Uzonna, ,Jude E.
author_role author
author2 Mou, Zhirong
Jia, Ping
Sharma, Rohit
Zayats, Romaniya
Viana, Sayonara M.
Shan, Lianyu
Barral, Aldina Maria Prado
Oliveira, Viviane Sampaio Boaventura de
Murooka, Thomas T.
Gounni, Abdel Soussi
Oliveira, Camila Indiani de
Uzonna, ,Jude E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gupta, Gaurav
Mou, Zhirong
Jia, Ping
Sharma, Rohit
Zayats, Romaniya
Viana, Sayonara M.
Shan, Lianyu
Barral, Aldina Maria Prado
Oliveira, Viviane Sampaio Boaventura de
Murooka, Thomas T.
Gounni, Abdel Soussi
Oliveira, Camila Indiani de
Uzonna, ,Jude E.
dc.subject.other.pt_BR.fl_str_mv Leishmaniose cutânea
Pele
Infecções
Camundongos
Patogênese Homeopática
topic Leishmaniose cutânea
Pele
Infecções
Camundongos
Patogênese Homeopática
Cutaneous Leishmaniasis
Skin
Infections
Mice
Pathogenesis, Homeopathic
dc.subject.en.pt_BR.fl_str_mv Cutaneous Leishmaniasis
Skin
Infections
Mice
Pathogenesis, Homeopathic
description Canadian Institutes of Health Research (CIHR) and Research Manitoba.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-02-11T13:47:19Z
dc.date.available.fl_str_mv 2021-02-11T13:47:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUPTA, Gaurav et al. The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response. Cell Reports, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46042
dc.identifier.issn.pt_BR.fl_str_mv 2211-1247
dc.identifier.doi.none.fl_str_mv 10.1016/j.celrep.2020.108513
identifier_str_mv GUPTA, Gaurav et al. The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response. Cell Reports, 2020.
2211-1247
10.1016/j.celrep.2020.108513
url https://www.arca.fiocruz.br/handle/icict/46042
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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