Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)

Leite, Maria Lea Correa; Moriguchi, Emílio Hideyuki; Costa, Maria Fernanda Furtado Lima

Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)

Detalhes bibliográficos
Autor(a) principal:	Leite, Maria Lea Correa
Data de Publicação:	2013
Outros Autores:	Moriguchi, Emílio Hideyuki, Costa, Maria Fernanda Furtado Lima
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/30427
Resumo:	2020-01-01

Metadados do item

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network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Leite, Maria Lea CorreaMoriguchi, Emílio HideyukiCosta, Maria Fernanda Furtado Lima2018-12-07T18:03:47Z2018-12-07T18:03:47Z2013LEITE, Maria Lea Correa; MORIGUCHI, Emilio Hideyuki; COSTA, Maria Fernanda Furtado Lima. Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008). Maturitas, v. 76, n. 1, p. 57-63, 2013.0378-5122https://www.arca.fiocruz.br/handle/icict/3042710.1016/j.maturitas.2013.05.012engElsevier/North Holland Biomedical PressConsumo de álcoolApolipoproteína EPressão sanguíneaObesidadeMenopausaAlcohol consumptionApolipoprotein EBlood pressureObesityMenopauseEffects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Institute of Biomedical Technologies. National Research Council.Milan, Italy.Universidade Federal do Rio Grande do Sul. Universidade do Vale dos Sinos. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil.Objectives: To evaluate the effects of interactions between ApoE genotypes, alcohol consumption and obesity on the age-related trends of blood pressure (BP) levels in postmenopausal women. Study design: A population-based prospective cohort study of all residents in Bambuì, south-eastern Brazil, aged 60 years or older. Repeated BP measurements were obtained in four waves from 851 women who underwent ApoE genotyping at baseline (88.3% of those enrolled), and multi-level random-effects pattern-mixture models were used to evaluate the age-related BP trajectories, while accounting for non-ignorable dropouts/deaths and handling heterogeneities as random parameter variations. The few measurements (2.1%) made during hormone replacement therapy were excluded from the analysis. Results: Alcohol consumption was associated with high levels of systolic and diastolic BP in an age × genotype-dependent manner only in the non-obese women (BMI < 27 kg/m2). Among those with the ɛ3/3 genotype, the differences in systolic and diastolic levels between drinkers and non-drinkers estimated at the age of 60 years were respectively 13.7 mmHg (p = 0.022) and 10.7 mmHg (p = 0.002), and disappeared in the older age groups, in which drinking was associated with systolic/diastolic hypertension if the non-obese women were ɛ4 carriers. Conclusion: In non-obese postmenopausal women, alcohol consumption is associated with systolic and diastolic hypertension early in those with the ɛ3/3 ApoE genotype, and late in ɛ4 carriers. We hypothesize the mediation of androgen hormones and the influence of ApoE genotypes on age at natural menopause. A better understanding of these mechanisms may guide better preventive choices.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/30427/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALEffects of interactions between ApoE polymorphisms.pdfEffects of interactions between ApoE polymorphisms.pdfapplication/pdf3936347https://www.arca.fiocruz.br/bitstream/icict/30427/2/Effects%20of%20interactions%20between%20ApoE%20polymorphisms.pdf97ed44e636c34616ab80e56da1a0f832MD52TEXTEffects of interactions between ApoE polymorphisms.pdf.txtEffects of interactions between ApoE polymorphisms.pdf.txtExtracted texttext/plain7https://www.arca.fiocruz.br/bitstream/icict/30427/3/Effects%20of%20interactions%20between%20ApoE%20polymorphisms.pdf.txt212b0306580d4f0044d18f9a3edcc832MD53icict/304272022-01-26 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dc.title.pt_BR.fl_str_mv	Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)
title	Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)
spellingShingle	Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008) Leite, Maria Lea Correa Consumo de álcool Apolipoproteína E Pressão sanguínea Obesidade Menopausa Alcohol consumption Apolipoprotein E Blood pressure Obesity Menopause
title_short	Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)
title_full	Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)
title_fullStr	Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)
title_full_unstemmed	Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)
title_sort	Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)
author	Leite, Maria Lea Correa
author_facet	Leite, Maria Lea Correa Moriguchi, Emílio Hideyuki Costa, Maria Fernanda Furtado Lima
author_role	author
author2	Moriguchi, Emílio Hideyuki Costa, Maria Fernanda Furtado Lima
author2_role	author author
dc.contributor.author.fl_str_mv	Leite, Maria Lea Correa Moriguchi, Emílio Hideyuki Costa, Maria Fernanda Furtado Lima
dc.subject.other.pt_BR.fl_str_mv	Consumo de álcool Apolipoproteína E Pressão sanguínea Obesidade Menopausa
topic	Consumo de álcool Apolipoproteína E Pressão sanguínea Obesidade Menopausa Alcohol consumption Apolipoprotein E Blood pressure Obesity Menopause
dc.subject.en.pt_BR.fl_str_mv	Alcohol consumption Apolipoprotein E Blood pressure Obesity Menopause
description	2020-01-01
publishDate	2013
dc.date.issued.fl_str_mv	2013
dc.date.accessioned.fl_str_mv	2018-12-07T18:03:47Z
dc.date.available.fl_str_mv	2018-12-07T18:03:47Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	LEITE, Maria Lea Correa; MORIGUCHI, Emilio Hideyuki; COSTA, Maria Fernanda Furtado Lima. Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008). Maturitas, v. 76, n. 1, p. 57-63, 2013.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/30427
dc.identifier.issn.pt_BR.fl_str_mv	0378-5122
dc.identifier.doi.none.fl_str_mv	10.1016/j.maturitas.2013.05.012
identifier_str_mv	LEITE, Maria Lea Correa; MORIGUCHI, Emilio Hideyuki; COSTA, Maria Fernanda Furtado Lima. Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008). Maturitas, v. 76, n. 1, p. 57-63, 2013. 0378-5122 10.1016/j.maturitas.2013.05.012
url	https://www.arca.fiocruz.br/handle/icict/30427
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier/North Holland Biomedical Press
publisher.none.fl_str_mv	Elsevier/North Holland Biomedical Press
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/30427/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/30427/2/Effects%20of%20interactions%20between%20ApoE%20polymorphisms.pdf https://www.arca.fiocruz.br/bitstream/icict/30427/3/Effects%20of%20interactions%20between%20ApoE%20polymorphisms.pdf.txt
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Effects of interactions between ApoE polymorphisms, alcohol consumption and obesity on age-related trends of blood pressure levels in postmenopausal women: the Bambuì cohort study of aging (1997-2008)

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