The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial

Detalhes bibliográficos
Autor(a) principal: Almeida, Maria Cecília F
Data de Publicação: 2012
Outros Autores: Lima, Givaneide dos Santos, Cardoso, Luciana Santos, Souza, Robson da Paixão de, Campos, Régis de Albuquerque, Cruz Filho, Alvaro Augusto Souza da, Figueiredo, Joanemile Pacheco de, Oliveira, Ricardo Riccio, Carvalho Filho, Edgar Marcelino, Araujo, Maria Ilma Andrade Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27159
Resumo: Carvalho Filho, Edgar Marcelino de; Oliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Almeida, Maria Cecília FLima, Givaneide dos SantosCardoso, Luciana SantosSouza, Robson da Paixão deCampos, Régis de AlbuquerqueCruz Filho, Alvaro Augusto Souza daFigueiredo, Joanemile Pacheco deOliveira, Ricardo RiccioCarvalho Filho, Edgar MarcelinoAraujo, Maria Ilma Andrade Santos2018-06-28T12:52:50Z2018-06-28T12:52:50Z2012ALMEIDA, M. C. F. et al. The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial. Journal of Parasitology Research, art. ID 296856, 11 pages, 2012.2090-0023https://www.arca.fiocruz.br/handle/icict/2715910.1155/2012/296856Carvalho Filho, Edgar Marcelino de; Oliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Brazilian National Research Council (CNPq). MIA, AAC and EMC are investigators supported by CNPq.Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Núcleo de Excelência em Asma. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciências e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilThis is a prospective, double-blinded, and placebo-controlled trial evaluating the influence of antihelminthic treatments on asthma severity in individuals living in an endemic area of schistosomiasis. Patients from group 1 received placebo of Albendazole or of Praziquantel and from group 2 received Albendazole and Praziquantel. Asthma severity was assessed by clinical scores and by pulmonary function test. There was no significant difference in the asthma scores from D0 to D1-D7 after Albendazole or Praziquantel and from D0 to D30-90 after Albendazole or Praziquantel in both, group 1 and 2. It was observed, however, a clinical worsening of the overall studied population after 6 months and 12 months of antihelminthic treatments. Additionally, we observed increased frequency of forced expiratory volume in 1 second (FEV1) <80% on 12 and 18 months after treatment. The worsening of asthma severity after repeated antihelminthic treatments is consistent with the hypothesis of the protective role conferred by helminths in atopic diseases.engHindawi Publishing CorporationAsmaEsquistossomeTratamentoPlaceboHumanosAsthmaSchistosomiasisTreatmentPlaceboHumansThe effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27159/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlmeida MCF The Effect of Antihelminthic Treatment ....pdfAlmeida MCF The Effect of Antihelminthic Treatment 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dc.title.pt_BR.fl_str_mv The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
title The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
spellingShingle The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
Almeida, Maria Cecília F
Asma
Esquistossome
Tratamento
Placebo
Humanos
Asthma
Schistosomiasis
Treatment
Placebo
Humans
title_short The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
title_full The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
title_fullStr The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
title_full_unstemmed The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
title_sort The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
author Almeida, Maria Cecília F
author_facet Almeida, Maria Cecília F
Lima, Givaneide dos Santos
Cardoso, Luciana Santos
Souza, Robson da Paixão de
Campos, Régis de Albuquerque
Cruz Filho, Alvaro Augusto Souza da
Figueiredo, Joanemile Pacheco de
Oliveira, Ricardo Riccio
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
author_role author
author2 Lima, Givaneide dos Santos
Cardoso, Luciana Santos
Souza, Robson da Paixão de
Campos, Régis de Albuquerque
Cruz Filho, Alvaro Augusto Souza da
Figueiredo, Joanemile Pacheco de
Oliveira, Ricardo Riccio
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Maria Cecília F
Lima, Givaneide dos Santos
Cardoso, Luciana Santos
Souza, Robson da Paixão de
Campos, Régis de Albuquerque
Cruz Filho, Alvaro Augusto Souza da
Figueiredo, Joanemile Pacheco de
Oliveira, Ricardo Riccio
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
dc.subject.other.pt_BR.fl_str_mv Asma
Esquistossome
Tratamento
Placebo
Humanos
topic Asma
Esquistossome
Tratamento
Placebo
Humanos
Asthma
Schistosomiasis
Treatment
Placebo
Humans
dc.subject.en.pt_BR.fl_str_mv Asthma
Schistosomiasis
Treatment
Placebo
Humans
description Carvalho Filho, Edgar Marcelino de; Oliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2018-06-28T12:52:50Z
dc.date.available.fl_str_mv 2018-06-28T12:52:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, M. C. F. et al. The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial. Journal of Parasitology Research, art. ID 296856, 11 pages, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27159
dc.identifier.issn.pt_BR.fl_str_mv 2090-0023
dc.identifier.doi.none.fl_str_mv 10.1155/2012/296856
identifier_str_mv ALMEIDA, M. C. F. et al. The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial. Journal of Parasitology Research, art. ID 296856, 11 pages, 2012.
2090-0023
10.1155/2012/296856
url https://www.arca.fiocruz.br/handle/icict/27159
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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