In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo de conferência |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23560 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil |
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Castro, Murilo FagundesMeira, Cássio SantanaBastos, Tanira MatutinoGuimarães, Elisalva TeixeiraMacambira, Simone GarciaSoares, Milena Botelho Pereira2017-12-07T19:26:57Z2017-12-07T19:26:57Z2012CASTRO, M. F. et al. In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.https://www.arca.fiocruz.br/handle/icict/23560engSociedade Brasileira de Medicina TropicalTrypanosoma cruziDoença de ChagasQuimioterapiaVitamina KMicroscopia eletrônicaHumanosTrypanosoma cruziChagas diseaseChemotherapyVitamin KElectron microscopyHumansIn vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin Kinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Federal University of Bahia. Department of Biophysics. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, BrazilAbout 10 million people worldwide are infected by Trypanosoma cruzi, etiologic agent of Chagas disease. The absence of effective trypanocidal chemotherapy reflects the need for constant research in this area. Some compounds such as naphtoquinones can reduce trypanothione reductase (TR), specific enzyme of trypanossomatids, which controls cellular oxidative stress. Inhibition of TR favors an oxidative process and death of the parasite. In this work, we investigate the trypanocidal potential of phytomenadione (K1) and menadione (K3), both vitamins K derived from naphthoquinones.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23560/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALChagas076 Castro MF In vitro and in vivo...SBMT 2012.pdfChagas076 Castro MF In vitro and in vivo...SBMT 2012.pdfapplication/pdf86668https://www.arca.fiocruz.br/bitstream/icict/23560/2/Chagas076%20Castro%20MF%20In%20vitro%20and%20in%20vivo...SBMT%202012.pdff0182914211c63d647102ccad0d09fd8MD52TEXTChagas076 Castro MF In vitro and in vivo...SBMT 2012.pdf.txtChagas076 Castro MF In vitro and in vivo...SBMT 2012.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K |
| title |
In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K |
| spellingShingle |
In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K Castro, Murilo Fagundes Trypanosoma cruzi Doença de Chagas Quimioterapia Vitamina K Microscopia eletrônica Humanos Trypanosoma cruzi Chagas disease Chemotherapy Vitamin K Electron microscopy Humans |
| title_short |
In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K |
| title_full |
In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K |
| title_fullStr |
In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K |
| title_full_unstemmed |
In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K |
| title_sort |
In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K |
| author |
Castro, Murilo Fagundes |
| author_facet |
Castro, Murilo Fagundes Meira, Cássio Santana Bastos, Tanira Matutino Guimarães, Elisalva Teixeira Macambira, Simone Garcia Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Meira, Cássio Santana Bastos, Tanira Matutino Guimarães, Elisalva Teixeira Macambira, Simone Garcia Soares, Milena Botelho Pereira |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Castro, Murilo Fagundes Meira, Cássio Santana Bastos, Tanira Matutino Guimarães, Elisalva Teixeira Macambira, Simone Garcia Soares, Milena Botelho Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Doença de Chagas Quimioterapia Vitamina K Microscopia eletrônica Humanos |
| topic |
Trypanosoma cruzi Doença de Chagas Quimioterapia Vitamina K Microscopia eletrônica Humanos Trypanosoma cruzi Chagas disease Chemotherapy Vitamin K Electron microscopy Humans |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas disease Chemotherapy Vitamin K Electron microscopy Humans |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
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2017-12-07T19:26:57Z |
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2017-12-07T19:26:57Z |
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info:eu-repo/semantics/publishedVersion |
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CASTRO, M. F. et al. In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/23560 |
| identifier_str_mv |
CASTRO, M. F. et al. In vitro and in vivo evaluation of anti-Trypanosoma cruzi activity of derivates of vitamin K. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012. |
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Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical |
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