Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach

Detalhes bibliográficos
Autor(a) principal: Barroso, Shana Priscila Coutinho
Data de Publicação: 2021
Outros Autores: Santos, Ana Clara Vicente dos, Santos, Patrícia Souza dos, Couceiro, José Nelson dos Santos Silva, Ferreira, Davis Fernandes, Nico, Dirlei, Morrot, Alexandre, Silva, Jerson Lima, Oliveira, Andrea Cheble de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47885
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Programa de Biologia Estrutural. Laboratório de Termodinâmica de Proteínas e Estruturas Virais Gregorio Weber. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Rj, Brasil / Marinha do Brasil. Hospital Naval Marcílio Dias. Instituto de Pesquisas Biomédicas. Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Barroso, Shana Priscila CoutinhoSantos, Ana Clara Vicente dosSantos, Patrícia Souza dosCouceiro, José Nelson dos Santos SilvaFerreira, Davis FernandesNico, DirleiMorrot, AlexandreSilva, Jerson LimaOliveira, Andrea Cheble de2021-06-27T12:00:52Z2021-06-27T12:00:52Z2021BARROSO, Shana Priscila Coutinho et al. Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach. Access Microbiology, v. 3, 000220, 8 p, Apr. 2021.2516-8290https://www.arca.fiocruz.br/handle/icict/4788510.1099/acmi.0.000220engMicrobiology SocietyInativaçãoVírus da gripe aviáriaPressão hidrostáticaDesenvolvimento de vacinaAvian influenza virusesInactivationHydrostatic pressurePotential vaccine developmentInactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approachinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Programa de Biologia Estrutural. Laboratório de Termodinâmica de Proteínas e Estruturas Virais Gregorio Weber. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Rj, Brasil / Marinha do Brasil. Hospital Naval Marcílio Dias. Instituto de Pesquisas Biomédicas. Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Programa de Biologia Estrutural. Laboratório de Termodinâmica de Proteínas e Estruturas Virais Gregorio Weber. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Rj, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Programa de Biologia Estrutural. Laboratório de Termodinâmica de Proteínas e Estruturas Virais Gregorio Weber. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Rj, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina, Departamento de Clínica Médica. Centro de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Programa de Biologia Estrutural. Laboratório de Termodinâmica de Proteínas e Estruturas Virais Gregorio Weber. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Rj, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Programa de Biologia Estrutural. Laboratório de Termodinâmica de Proteínas e Estruturas Virais Gregorio Weber. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Rj, BrasilVaccines are a recommended strategy for controlling influenza A infections in humans and animals. Here, we describe the effects of hydrostatic pressure on the structure, morphology and functional characteristics of avian influenza A H3N8 virus. The effect of hydrostatic pressure for 3h on H3N8 virus revealed that the particles were resistant to this condition, and the virus displayed only a discrete conformational change. We found that pressure of 3 kbar applied for 6h was able to inhibit haemag glutination and infectivity while virus replication was no longer observed, suggesting that full virus inactivation occurred at this point. However, the neuraminidase activity was not affected at this approach suggesting the maintenance of neutralizing anti body epitopes in this key antigen. Our data bring important information for the area of structural virology of enveloped particles and support the idea of applying pressure-induced inactivation as a tool for vaccine production.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47885/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlexandreMorrot_ShanaBarroso_etal_IOC_2021.pdfAlexandreMorrot_ShanaBarroso_etal_IOC_2021.pdfapplication/pdf1391142https://www.arca.fiocruz.br/bitstream/icict/47885/2/AlexandreMorrot_ShanaBarroso_etal_IOC_2021.pdfda3b9da1164fab929389065588005410MD52TEXTAlexandreMorrot_ShanaBarroso_etal_IOC_2021.pdf.txtAlexandreMorrot_ShanaBarroso_etal_IOC_2021.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach
title Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach
spellingShingle Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach
Barroso, Shana Priscila Coutinho
Inativação
Vírus da gripe aviária
Pressão hidrostática
Desenvolvimento de vacina
Avian influenza viruses
Inactivation
Hydrostatic pressure
Potential vaccine development
title_short Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach
title_full Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach
title_fullStr Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach
title_full_unstemmed Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach
title_sort Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach
author Barroso, Shana Priscila Coutinho
author_facet Barroso, Shana Priscila Coutinho
Santos, Ana Clara Vicente dos
Santos, Patrícia Souza dos
Couceiro, José Nelson dos Santos Silva
Ferreira, Davis Fernandes
Nico, Dirlei
Morrot, Alexandre
Silva, Jerson Lima
Oliveira, Andrea Cheble de
author_role author
author2 Santos, Ana Clara Vicente dos
Santos, Patrícia Souza dos
Couceiro, José Nelson dos Santos Silva
Ferreira, Davis Fernandes
Nico, Dirlei
Morrot, Alexandre
Silva, Jerson Lima
Oliveira, Andrea Cheble de
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barroso, Shana Priscila Coutinho
Santos, Ana Clara Vicente dos
Santos, Patrícia Souza dos
Couceiro, José Nelson dos Santos Silva
Ferreira, Davis Fernandes
Nico, Dirlei
Morrot, Alexandre
Silva, Jerson Lima
Oliveira, Andrea Cheble de
dc.subject.other.pt_BR.fl_str_mv Inativação
Vírus da gripe aviária
Pressão hidrostática
Desenvolvimento de vacina
topic Inativação
Vírus da gripe aviária
Pressão hidrostática
Desenvolvimento de vacina
Avian influenza viruses
Inactivation
Hydrostatic pressure
Potential vaccine development
dc.subject.en.pt_BR.fl_str_mv Avian influenza viruses
Inactivation
Hydrostatic pressure
Potential vaccine development
description Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Biologia Estrutural. Programa de Biologia Estrutural. Laboratório de Termodinâmica de Proteínas e Estruturas Virais Gregorio Weber. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Rj, Brasil / Marinha do Brasil. Hospital Naval Marcílio Dias. Instituto de Pesquisas Biomédicas. Laboratório de Biologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-27T12:00:52Z
dc.date.available.fl_str_mv 2021-06-27T12:00:52Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARROSO, Shana Priscila Coutinho et al. Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach. Access Microbiology, v. 3, 000220, 8 p, Apr. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47885
dc.identifier.issn.pt_BR.fl_str_mv 2516-8290
dc.identifier.doi.none.fl_str_mv 10.1099/acmi.0.000220
identifier_str_mv BARROSO, Shana Priscila Coutinho et al. Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach. Access Microbiology, v. 3, 000220, 8 p, Apr. 2021.
2516-8290
10.1099/acmi.0.000220
url https://www.arca.fiocruz.br/handle/icict/47885
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Microbiology Society
publisher.none.fl_str_mv Microbiology Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instacron_str FIOCRUZ
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