In vitro and in vivo experimental models for drug screening and development for Chagas disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5794 |
Resumo: | Fiocruz, DNDi |
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Romanha, Álvaro JoséCastro, Solange Lisboa deSoeiro, Maria de Nazaré CorreiaVieira, Joseli LannesRibeiro, IsabelaTalvani, AndréBourdin, BernadetteBlum, BethaniaOlivieri, BiancaZani, Carlos LeomarSpadafora, CarmenzaChiari, ÉglerChatelain, EricChaves, GabrielaCalzada, José EduardoBustamante, Juan ManuelFreitas Junior, Lucio Holanda Gondim deRomero, Luz I.Bahia, Maria TerezinhaLotrowska, MichelSoares, Milena Botelho PereiraAndrade, Sonia GumesArmstrong, TanyaDegrave, WimAndrade, Zilton de Araújo2012-11-12T19:20:36Z20122010ROMANHA, Alvaro et al. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 105(2): 233-238, March 20100074-0276https://www.arca.fiocruz.br/handle/icict/5794Fiocruz, DNDiFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil/Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Drugs for Neglected Disease Initiative.Geneva, SwitzerlandUniversidade Federal de Ouro Preto. Departamento de Ciências Biológicas. Ouro Preto, MG, Brasil.Drugs for Neglected Disease Initiative. Geneva, Switzerland.Drugs for Neglected Disease Initiative, Geneva, Switzerland.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.Instituto de Investigaciones Científicas y Servicios de Alta Tecnologia- AIP. Clayton, Panamá.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.Drugs for Neglected Disease Initiative.Geneva, SwitzerlandMédecins sans Frontières. Geneva, Switzerland.Instituto Conmemorativo Gorgas de Estudios de la Salud. Panamá, Panamá.University of Georgia. Center for Tropical and Emerging Global Disease. GA, USA..Institute Pasteur-Korea. Center for Neglected Diseases Drug Discovery. Gyeonggi-do, Korea.Instituto de Investigaciones Científicas y Servicios de Alta Tecnologia-AIP. Clayton, Panamá.Universidade Federal de Ouro Preto. Departamento de Ciências Biológicas. Ouro Preto, MG, Brasil.Drugs for Neglected Disease Initiative. Geneva, Switzerland.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Murdoch University. Murdoch, AustráliaPrograma Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil / Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa Integrado de Doença de Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Al¬though the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still remain serious challenges, including the maintenance of sustainable public policies for Chagas disease control and the urgent need for better drugs to treat chagasic patients. Since the introduction of benznidazole and nifurtimox approximately 40 years ago, many natural and synthetic compounds have been as¬sayed against Trypanosoma cruzi, yet only a few compounds have advanced to clinical trials. This reflects, at least in part, the lack of consensus regarding appropriate in vitro and in vivo screening protocols as well as the lack of biomarkers for treating parasitaemia. The development of more effective drugs requires (i) the identification and validation of parasite targets, (ii) compounds to be screened against the targets or the whole parasite and (iii) a panel of minimum standardised procedures to advance leading compounds to clinical trials. This third aim was the topic of the workshop entitled Experimental Models in Drug Screening and Development for Chagas Disease, held in Rio de Janeiro, Brazil, on the 25th and 26th of November 2008 by the Fiocruz Program for Research and Technological Development on Chagas Disease and Drugs for Neglected Diseases Initiative. During the meeting, the minimum steps, requirements and decision gates for the determination of the efficacy of novel drugs for T. cruzi control were evaluated by interdisciplinary experts and an in vitro and in vivo flowchart was designed to serve as a general and standardised protocol for screening potential drugs for the treatment of Chagas disease.engInstituto Oswaldo CruzIn vitro and in vivo experimental models for drug screening and development for Chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTrypanosoma cruziChagas disease treatmentdrug screeningbenznidazoleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL100.2010.pdf100.2010.pdfapplication/pdf628329https://www.arca.fiocruz.br/bitstream/icict/5794/1/100.2010.pdfe376150db1b041e55dd80e513a9798f8MD51TEXT100.2010.pdf.txt100.2010.pdf.txtExtracted texttext/plain36120https://www.arca.fiocruz.br/bitstream/icict/5794/4/100.2010.pdf.txt96b23f6b75d052e80cf4166c19466f2bMD54THUMBNAIL100.2010.pdf.jpg100.2010.pdf.jpgGenerated Thumbnailimage/jpeg2263https://www.arca.fiocruz.br/bitstream/icict/5794/3/100.2010.pdf.jpg40d2de8f36d962bbe4afca3b0ea54bcfMD53icict/57942023-09-05 10:30:54.912oai:www.arca.fiocruz.br:icict/5794Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:30:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
In vitro and in vivo experimental models for drug screening and development for Chagas disease |
| title |
In vitro and in vivo experimental models for drug screening and development for Chagas disease |
| spellingShingle |
In vitro and in vivo experimental models for drug screening and development for Chagas disease Romanha, Álvaro José Trypanosoma cruzi Chagas disease treatment drug screening benznidazole |
| title_short |
In vitro and in vivo experimental models for drug screening and development for Chagas disease |
| title_full |
In vitro and in vivo experimental models for drug screening and development for Chagas disease |
| title_fullStr |
In vitro and in vivo experimental models for drug screening and development for Chagas disease |
| title_full_unstemmed |
In vitro and in vivo experimental models for drug screening and development for Chagas disease |
| title_sort |
In vitro and in vivo experimental models for drug screening and development for Chagas disease |
| author |
Romanha, Álvaro José |
| author_facet |
Romanha, Álvaro José Castro, Solange Lisboa de Soeiro, Maria de Nazaré Correia Vieira, Joseli Lannes Ribeiro, Isabela Talvani, André Bourdin, Bernadette Blum, Bethania Olivieri, Bianca Zani, Carlos Leomar Spadafora, Carmenza Chiari, Égler Chatelain, Eric Chaves, Gabriela Calzada, José Eduardo Bustamante, Juan Manuel Freitas Junior, Lucio Holanda Gondim de Romero, Luz I. Bahia, Maria Terezinha Lotrowska, Michel Soares, Milena Botelho Pereira Andrade, Sonia Gumes Armstrong, Tanya Degrave, Wim Andrade, Zilton de Araújo |
| author_role |
author |
| author2 |
Castro, Solange Lisboa de Soeiro, Maria de Nazaré Correia Vieira, Joseli Lannes Ribeiro, Isabela Talvani, André Bourdin, Bernadette Blum, Bethania Olivieri, Bianca Zani, Carlos Leomar Spadafora, Carmenza Chiari, Égler Chatelain, Eric Chaves, Gabriela Calzada, José Eduardo Bustamante, Juan Manuel Freitas Junior, Lucio Holanda Gondim de Romero, Luz I. Bahia, Maria Terezinha Lotrowska, Michel Soares, Milena Botelho Pereira Andrade, Sonia Gumes Armstrong, Tanya Degrave, Wim Andrade, Zilton de Araújo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Romanha, Álvaro José Castro, Solange Lisboa de Soeiro, Maria de Nazaré Correia Vieira, Joseli Lannes Ribeiro, Isabela Talvani, André Bourdin, Bernadette Blum, Bethania Olivieri, Bianca Zani, Carlos Leomar Spadafora, Carmenza Chiari, Égler Chatelain, Eric Chaves, Gabriela Calzada, José Eduardo Bustamante, Juan Manuel Freitas Junior, Lucio Holanda Gondim de Romero, Luz I. Bahia, Maria Terezinha Lotrowska, Michel Soares, Milena Botelho Pereira Andrade, Sonia Gumes Armstrong, Tanya Degrave, Wim Andrade, Zilton de Araújo |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas disease treatment drug screening benznidazole |
| topic |
Trypanosoma cruzi Chagas disease treatment drug screening benznidazole |
| description |
Fiocruz, DNDi |
| publishDate |
2010 |
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2010 |
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2012-11-12T19:20:36Z |
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2012 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
ROMANHA, Alvaro et al. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 105(2): 233-238, March 2010 |
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https://www.arca.fiocruz.br/handle/icict/5794 |
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0074-0276 |
| identifier_str_mv |
ROMANHA, Alvaro et al. In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 105(2): 233-238, March 2010 0074-0276 |
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https://www.arca.fiocruz.br/handle/icict/5794 |
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eng |
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Instituto Oswaldo Cruz |
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Instituto Oswaldo Cruz |
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