Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta

Detalhes bibliográficos
Autor(a) principal: Amaral, V. F.
Data de Publicação: 2000
Outros Autores: Pirmez, Claude, Gonçalves, A. J. S., Ferreira, V., Grimaldi Jr., Gabriel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/S0074-02762000000200012
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44053
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Amaral, V. F.Pirmez, ClaudeGonçalves, A. J. S.Ferreira, V.Grimaldi Jr., Gabriel2020-10-19T14:27:59Z2020-10-19T14:27:59Z2000AMARAL, V. F. et al. Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 95, n. 2, p. 209-216, Mar./Apr. 2000.0074-0276https://www.arca.fiocruz.br/handle/icict/4405310.1590/S0074-027620000002000121678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Leishmania (L.) amazonensisMacaca mulattaLeishmaniose experimentalImunidade celular sistêmica e localLeishmania (L.) amazonensisMacaca mulattaExperimental leishmaniasisSystemic and local cellular immunityCell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulattainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. epartamento de Primatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.The cellular nature of the infiltrate in cutaneous lesion of rhesus monkeys experimentally infected with Leishmania (L.) amazonensis was characterized by immunohistochemistry. Skin biopsies from infected animals with active or healing lesions were compared to non-infected controls (three of each type) to quantitate inflammatory cell types. Inflammatory cells (composed of a mixture of T lymphocyte subpopulations, macrophages and a small number of natural killer cells and granulocytes) were more numerous in active lesions than in healing ones. T-cells accounted for 44.7 ± 13.1% of the infiltrate in active lesions (versus CD2+ = 40.3 ± 5.7% in healing lesions) and T-cell ratios favor CD8+ cells in both lesion types. The percentage of cells expressing class II antigen (HLADR+) in active lesions (95 ± 7.1%) was significantly higher (P < 0.005) from the healing lesions (42.7 ± 12.7%). Moreover, the expression of the activation molecules CD25 (≅ 16%), the receptor for interleukin2, suggests that many T cells are primed and proliferating in active lesions. Distinct histopathological patterns were observed in lesions at biopsy, but healing lesions contained more organized epithelioid granulomas and activated macrophages, followed by fibrotic substitution. The progression and resolution of skin lesions appears to be very similar to that observed in humans, confirming the potential for this to be used as a viable model to study the immune response in human cutaneous leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44053/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVFA_Amaral_etal_IOC_2000.pdfVFA_Amaral_etal_IOC_2000.pdfapplication/pdf328011https://www.arca.fiocruz.br/bitstream/icict/44053/2/VFA_Amaral_etal_IOC_2000.pdf542e440ff74883136b0b9877ad2749e4MD52TEXTVFA_Amaral_etal_IOC_2000.pdf.txtVFA_Amaral_etal_IOC_2000.pdf.txtExtracted texttext/plain32607https://www.arca.fiocruz.br/bitstream/icict/44053/3/VFA_Amaral_etal_IOC_2000.pdf.txtd7a74b616e90be6428a045a16d7789f5MD53icict/440532022-06-24 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dc.title.pt_BR.fl_str_mv Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta
title Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta
spellingShingle Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta
Amaral, V. F.
Leishmania (L.) amazonensis
Macaca mulatta
Leishmaniose experimental
Imunidade celular sistêmica e local
Leishmania (L.) amazonensis
Macaca mulatta
Experimental leishmaniasis
Systemic and local cellular immunity
title_short Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta
title_full Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta
title_fullStr Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta
title_full_unstemmed Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta
title_sort Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta
author Amaral, V. F.
author_facet Amaral, V. F.
Pirmez, Claude
Gonçalves, A. J. S.
Ferreira, V.
Grimaldi Jr., Gabriel
author_role author
author2 Pirmez, Claude
Gonçalves, A. J. S.
Ferreira, V.
Grimaldi Jr., Gabriel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Amaral, V. F.
Pirmez, Claude
Gonçalves, A. J. S.
Ferreira, V.
Grimaldi Jr., Gabriel
dc.subject.other.pt_BR.fl_str_mv Leishmania (L.) amazonensis
Macaca mulatta
Leishmaniose experimental
Imunidade celular sistêmica e local
topic Leishmania (L.) amazonensis
Macaca mulatta
Leishmaniose experimental
Imunidade celular sistêmica e local
Leishmania (L.) amazonensis
Macaca mulatta
Experimental leishmaniasis
Systemic and local cellular immunity
dc.subject.en.pt_BR.fl_str_mv Leishmania (L.) amazonensis
Macaca mulatta
Experimental leishmaniasis
Systemic and local cellular immunity
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2020-10-19T14:27:59Z
dc.date.available.fl_str_mv 2020-10-19T14:27:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AMARAL, V. F. et al. Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 95, n. 2, p. 209-216, Mar./Apr. 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44053
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762000000200012
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv AMARAL, V. F. et al. Cell Populations in Lesions of Cutaneous Leishmaniasis of Leishmania (L.) amazonensis-infected Rhesus Macaques, Macaca mulatta. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 95, n. 2, p. 209-216, Mar./Apr. 2000.
0074-0276
10.1590/S0074-02762000000200012
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44053
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/44053/3/VFA_Amaral_etal_IOC_2000.pdf.txt
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