Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/30797 |
Resumo: | FACEPE (Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco) and Programa de Pós-Graduação em Bolsas da Universidade de Pernambuco. |
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Vasconcelos, Luydson Richardson SilvaFonseca, Juliana Pereira LopesCarmo, Rodrigo Feliciano doMendonça, Taciana Furtado dePereira, Valeria Rêgo AlvesLucena-Silva, NormaPereira, Leila Maria Moreira BeltrãoMoura, PatríciaCavalcanti, Maria do Socorro de Mendonça2018-12-28T13:12:26Z2018-12-28T13:12:26Z2011VASCONCELOS, Luydson Richardson Silva et al. Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes. International Journal of Infectious Diseases, v. 15, n. 8, p. e551–e557, 1 ago. 2011.1878-3511https://www.arca.fiocruz.br/handle/icict/3079710.1016/j.ijid.2011.04.008FACEPE (Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco) and Programa de Pós-Graduação em Bolsas da Universidade de Pernambuco.Universidade de Pernambuco. Instituto de Ciências Biológicas. Faculdade de Ciências Medicas. Recife PE, Brasil. / Instituto do Fígado de Pernambuco. Recife PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Faculdade de Ciências Medicas. Recife PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Faculdade de Ciências Medicas. Recife PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Faculdade de Ciências Medicas. Recife PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. / Instituto de Medicina Integral Professor Fernando Figueira. Recife PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Faculdade de Ciências Medicas. Recife PE, Brasil. / Instituto do Fígado de Pernambuco. Recife PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Faculdade de Ciências Medicas. Recife PE, Brasil.Universidade de Pernambuco. Instituto de Ciências Biológicas. Faculdade de Ciências Medicas. Recife PE, Brasil.Mannose-binding lectin (MBL) activates the complement system promoting opsonophagocytosis, which could represent an advantage for Mycobacterium leprae, an intracellular pathogen. Therefore, a single nucleotide polymorphism (SNP) in the MBL2 gene associated with low levels of MBL could confer protection against the development of leprosy disease.engMannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMannose-binding lectinMBL2LeprosyInnate immunityAgePolymorphismAdolescenteAdultoIdade FatoresEnvelhecidoIdoso, 80 anos ou maisBrasilEstudos de caso-controleCriançaCriança, pré-escolarFêmeaGenótipoHaplótiposHumanosImunidade InataLepra / sangueLepra / microbiologiaMasculinoLectina de Ligação com Manose / sangueLectina de Ligação a Manose / genéticaMeia idadeMycobacterium leprae / genéticaOdds RatioPolimorfismo de nucleotídeo único / genéticaAdulto joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes |
| title |
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes |
| spellingShingle |
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes Vasconcelos, Luydson Richardson Silva Mannose-binding lectin MBL2 Leprosy Innate immunity Age Polymorphism Adolescente Adulto Idade Fatores Envelhecido Idoso, 80 anos ou mais Brasil Estudos de caso-controle Criança Criança, pré-escolar Fêmea Genótipo Haplótipos Humanos Imunidade Inata Lepra / sangue Lepra / microbiologia Masculino Lectina de Ligação com Manose / sangue Lectina de Ligação a Manose / genética Meia idade Mycobacterium leprae / genética Odds Ratio Polimorfismo de nucleotídeo único / genética Adulto jovem |
| title_short |
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes |
| title_full |
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes |
| title_fullStr |
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes |
| title_full_unstemmed |
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes |
| title_sort |
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes |
| author |
Vasconcelos, Luydson Richardson Silva |
| author_facet |
Vasconcelos, Luydson Richardson Silva Fonseca, Juliana Pereira Lopes Carmo, Rodrigo Feliciano do Mendonça, Taciana Furtado de Pereira, Valeria Rêgo Alves Lucena-Silva, Norma Pereira, Leila Maria Moreira Beltrão Moura, Patrícia Cavalcanti, Maria do Socorro de Mendonça |
| author_role |
author |
| author2 |
Fonseca, Juliana Pereira Lopes Carmo, Rodrigo Feliciano do Mendonça, Taciana Furtado de Pereira, Valeria Rêgo Alves Lucena-Silva, Norma Pereira, Leila Maria Moreira Beltrão Moura, Patrícia Cavalcanti, Maria do Socorro de Mendonça |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vasconcelos, Luydson Richardson Silva Fonseca, Juliana Pereira Lopes Carmo, Rodrigo Feliciano do Mendonça, Taciana Furtado de Pereira, Valeria Rêgo Alves Lucena-Silva, Norma Pereira, Leila Maria Moreira Beltrão Moura, Patrícia Cavalcanti, Maria do Socorro de Mendonça |
| dc.subject.en.pt_BR.fl_str_mv |
Mannose-binding lectin MBL2 Leprosy Innate immunity Age Polymorphism |
| topic |
Mannose-binding lectin MBL2 Leprosy Innate immunity Age Polymorphism Adolescente Adulto Idade Fatores Envelhecido Idoso, 80 anos ou mais Brasil Estudos de caso-controle Criança Criança, pré-escolar Fêmea Genótipo Haplótipos Humanos Imunidade Inata Lepra / sangue Lepra / microbiologia Masculino Lectina de Ligação com Manose / sangue Lectina de Ligação a Manose / genética Meia idade Mycobacterium leprae / genética Odds Ratio Polimorfismo de nucleotídeo único / genética Adulto jovem |
| dc.subject.decs.pt_BR.fl_str_mv |
Adolescente Adulto Idade Fatores Envelhecido Idoso, 80 anos ou mais Brasil Estudos de caso-controle Criança Criança, pré-escolar Fêmea Genótipo Haplótipos Humanos Imunidade Inata Lepra / sangue Lepra / microbiologia Masculino Lectina de Ligação com Manose / sangue Lectina de Ligação a Manose / genética Meia idade Mycobacterium leprae / genética Odds Ratio Polimorfismo de nucleotídeo único / genética Adulto jovem |
| description |
FACEPE (Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco) and Programa de Pós-Graduação em Bolsas da Universidade de Pernambuco. |
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2011 |
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2011 |
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2018-12-28T13:12:26Z |
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2018-12-28T13:12:26Z |
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VASCONCELOS, Luydson Richardson Silva et al. Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes. International Journal of Infectious Diseases, v. 15, n. 8, p. e551–e557, 1 ago. 2011. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/30797 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1878-3511 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.ijid.2011.04.008 |
| identifier_str_mv |
VASCONCELOS, Luydson Richardson Silva et al. Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes. International Journal of Infectious Diseases, v. 15, n. 8, p. e551–e557, 1 ago. 2011. 1878-3511 10.1016/j.ijid.2011.04.008 |
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