Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach

Detalhes bibliográficos
Autor(a) principal: Guimarães, Monick Lindenmeyer
Data de Publicação: 2015
Outros Autores: Marques, Bianca Cristina Leires, Bertoni, Neilane, Teixeira, Sylvia Lopes Maia, Morgado, Mariza Gonçalves, Bastos, Francisco Inácio Pinkusfeld Monteiro, Misuse, Brazilian Brazilian Multicity Study Group on Drug
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12947
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Guimarães, Monick LindenmeyerMarques, Bianca Cristina LeiresBertoni, NeilaneTeixeira, Sylvia Lopes MaiaMorgado, Mariza GonçalvesBastos, Francisco Inácio Pinkusfeld MonteiroMisuse, Brazilian Brazilian Multicity Study Group on Drug2016-03-03T11:00:35Z2016-03-03T11:00:35Z2015GUIMARÃES, Monick Lindenmeyer; et al. Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach. Plos One, v.10, n.11, 17p, Nov. 2015.1932-6203https://www.arca.fiocruz.br/handle/icict/1294710.1371/journal. pone.0141372engPublic Library of ScienceHIV-1Epidemiologia MolecularUsuários de DrogasBrasilHIV-1Brazilian Drug UsersMolecular EpidemiologyAssessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approachinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz.Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz.Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil.Brazilian Multicity Study Group on Drug Misuse.Person who inject illicit substances have an important role in HIV-1 blood and sexual transmission and together with person who uses heavy non-injecting drugs may have less than optimal adherence to anti-retroviral treatment and eventually could transmit resistant HIV variants. Unfortunately, molecular biology data on such key population remain fragmentary in most low and middle-income countries. The aim of the present study was to assess HIV infection rates, evaluate HIV-1 genetic diversity, drug resistance, and to identify HIV transmission clusters in heavy drug users (DUs). For this purpose, DUs were recruited in the context of a Respondent-Driven Sampling (RDS) study in different Brazilian cities during 2009. Overall, 2,812 individuals were tested for HIV, and 168 (6%) of them were positive, of which 19 (11.3%) were classified as recent seroconverters, corresponding to an estimated incidence rate of 1.58%/year (95% CI 0.92–2.43%). Neighbor joining phylogenetic trees from env and pol regions and bootscan analyses were employed to subtype the virus from132 HIV-1-infected individuals. HIV-1 subtype B was prevalent in most of the cities under analysis, followed by BF recombinants (9%-35%). HIV-1 subtype C was the most prevalent in Curitiba (46%) and Itajaí (86%) and was also detected in Brasília (9%) and Campo Grande (20%). Pure HIV-1F infections were detected in Rio de Janeiro (9%), Recife (6%), Salvador (6%) and Brasília (9%). Clusters of HIV transmission were assessed by Maximum likelihood analyses and were cross-compared with the RDS network structure. Drug resistance mutations were verified in 12.2% of DUs. Our findings reinforce the importance of the permanent HIV-1 surveillance in distinct Brazilian cities due to viral resistance and increasing subtype heterogeneity all over Brazil, with relevant implications in terms of treatment monitoring, prophylaxis and vaccine development.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12947/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmonick_guimaraes_etal_IOC_2015.PDFmonick_guimaraes_etal_IOC_2015.PDFapplication/pdf2515006https://www.arca.fiocruz.br/bitstream/icict/12947/2/monick_guimaraes_etal_IOC_2015.PDF3e3ad7df1c9fade32f6a9d42350acef5MD52TEXTmonick_guimaraes_etal_IOC_2015.PDF.txtmonick_guimaraes_etal_IOC_2015.PDF.txtExtracted 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dc.title.pt_BR.fl_str_mv Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach
title Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach
spellingShingle Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach
Guimarães, Monick Lindenmeyer
HIV-1
Epidemiologia Molecular
Usuários de Drogas
Brasil
HIV-1
Brazilian Drug Users
Molecular Epidemiology
title_short Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach
title_full Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach
title_fullStr Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach
title_full_unstemmed Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach
title_sort Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach
author Guimarães, Monick Lindenmeyer
author_facet Guimarães, Monick Lindenmeyer
Marques, Bianca Cristina Leires
Bertoni, Neilane
Teixeira, Sylvia Lopes Maia
Morgado, Mariza Gonçalves
Bastos, Francisco Inácio Pinkusfeld Monteiro
Misuse, Brazilian Brazilian Multicity Study Group on Drug
author_role author
author2 Marques, Bianca Cristina Leires
Bertoni, Neilane
Teixeira, Sylvia Lopes Maia
Morgado, Mariza Gonçalves
Bastos, Francisco Inácio Pinkusfeld Monteiro
Misuse, Brazilian Brazilian Multicity Study Group on Drug
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães, Monick Lindenmeyer
Marques, Bianca Cristina Leires
Bertoni, Neilane
Teixeira, Sylvia Lopes Maia
Morgado, Mariza Gonçalves
Bastos, Francisco Inácio Pinkusfeld Monteiro
Misuse, Brazilian Brazilian Multicity Study Group on Drug
dc.subject.other.pt_BR.fl_str_mv HIV-1
Epidemiologia Molecular
Usuários de Drogas
Brasil
topic HIV-1
Epidemiologia Molecular
Usuários de Drogas
Brasil
HIV-1
Brazilian Drug Users
Molecular Epidemiology
dc.subject.en.pt_BR.fl_str_mv HIV-1
Brazilian Drug Users
Molecular Epidemiology
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-03-03T11:00:35Z
dc.date.available.fl_str_mv 2016-03-03T11:00:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUIMARÃES, Monick Lindenmeyer; et al. Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach. Plos One, v.10, n.11, 17p, Nov. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12947
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal. pone.0141372
identifier_str_mv GUIMARÃES, Monick Lindenmeyer; et al. Assessing the HIV-1 Epidemic in Brazilian Drug Users: A Molecular Epidemiology Approach. Plos One, v.10, n.11, 17p, Nov. 2015.
1932-6203
10.1371/journal. pone.0141372
url https://www.arca.fiocruz.br/handle/icict/12947
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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