Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins

Detalhes bibliográficos
Autor(a) principal: Cavada, Benildo Sousa
Data de Publicação: 2001
Outros Autores: Bessa, Theolis Costa Barbosa, Arruda, Sérgio Marcos, Grangeiro, Thalles Barbosa, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7439
Resumo: Universidade Federal do Ceará. BioMol – Laboratório. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, Brasil.
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spelling Cavada, Benildo SousaBessa, Theolis Costa BarbosaArruda, Sérgio MarcosGrangeiro, Thalles BarbosaBarral Netto, Manoel2014-03-24T17:08:26Z2014-03-24T17:08:26Z2001CAVADA, B. et al. Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins. Current Protein and Peptide Science, v. 2, p. 123-135, 2001.1389-2037https://www.arca.fiocruz.br/handle/icict/7439engBentham Science Publishers Ltd.Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Ceará. BioMol – Laboratório. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil.Universidade Federal do Ceará. BioMol – Laboratório. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, Brasil / Universidade Federal do Ceará. Laboratório de Citogenética e Genética Molecular. Departamento de Biologia. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil.Significant differences in function have been observed among lectins structurally similar to concanavalin A, but their high homology with this widely used lectin has kept them in obscurity. The observation of large differences in the potency of many of these Diocleinae lectins as stimulators of Interferon-g production by human peripheral blood mononuclear cells has lead to a major effort to unravel their chemical structure and biological activity. Modeling studies of some of these lectins reveal conformational changes in side chains of some residues involved in the carbohydrate-binding site, with possible effects on the ability of these proteins to recognize specific carbohydrate structures. Additionally, all them constitute in fact a mixture of isolectins, which in different proportions could lead to diverse effects. The present review of the biological actions of Diocleinae lectins includes several in vitro and in vivo immunological findings, as well as their effects on insect growth and reproduction. In these systems Diocleinae lectins proved to be quite diverse in their potency. Such diversity in the biological activity of highly related proteins recalls the origin of the name protein: like Proteus, the capability of assuming various forms is the essential feature of this class of molecules.Lectinas/químicaLectinas/farmacologiaSequência de AminoácidosAnimaisBiotecnologiaFabaceae/químicaFabaceae/genéticaHumanosLectinas/genéticaDados de Sequência MolecularHomologia de Sequência de AminoácidosRelação Estrutura-Atividadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCavada B Revisiting proteus....pdfCavada B Revisiting proteus....pdfapplication/pdf59350https://www.arca.fiocruz.br/bitstream/icict/7439/1/Cavada%20B%20Revisiting%20proteus....pdf01b4aff56b7c0489edc0e5024ebedea6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7439/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCavada B Revisiting proteus....pdf.txtCavada B Revisiting proteus....pdf.txtExtracted texttext/plain45808https://www.arca.fiocruz.br/bitstream/icict/7439/5/Cavada%20B%20Revisiting%20proteus....pdf.txt21df2501f4ee49ef92867e3bce509970MD55THUMBNAILCavada B Revisiting proteus....pdf.jpgCavada B Revisiting proteus....pdf.jpgGenerated Thumbnailimage/jpeg2377https://www.arca.fiocruz.br/bitstream/icict/7439/4/Cavada%20B%20Revisiting%20proteus....pdf.jpg75cc29d9acf43a0b3b052cdaac9e8f74MD54icict/74392023-03-15 14:34:19.559oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
title Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
spellingShingle Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
Cavada, Benildo Sousa
Lectinas/química
Lectinas/farmacologia
Sequência de Aminoácidos
Animais
Biotecnologia
Fabaceae/química
Fabaceae/genética
Humanos
Lectinas/genética
Dados de Sequência Molecular
Homologia de Sequência de Aminoácidos
Relação Estrutura-Atividade
title_short Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
title_full Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
title_fullStr Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
title_full_unstemmed Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
title_sort Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins
author Cavada, Benildo Sousa
author_facet Cavada, Benildo Sousa
Bessa, Theolis Costa Barbosa
Arruda, Sérgio Marcos
Grangeiro, Thalles Barbosa
Barral Netto, Manoel
author_role author
author2 Bessa, Theolis Costa Barbosa
Arruda, Sérgio Marcos
Grangeiro, Thalles Barbosa
Barral Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cavada, Benildo Sousa
Bessa, Theolis Costa Barbosa
Arruda, Sérgio Marcos
Grangeiro, Thalles Barbosa
Barral Netto, Manoel
dc.subject.decs.pt_BR.fl_str_mv Lectinas/química
Lectinas/farmacologia
Sequência de Aminoácidos
Animais
Biotecnologia
Fabaceae/química
Fabaceae/genética
Humanos
Lectinas/genética
Dados de Sequência Molecular
Homologia de Sequência de Aminoácidos
Relação Estrutura-Atividade
topic Lectinas/química
Lectinas/farmacologia
Sequência de Aminoácidos
Animais
Biotecnologia
Fabaceae/química
Fabaceae/genética
Humanos
Lectinas/genética
Dados de Sequência Molecular
Homologia de Sequência de Aminoácidos
Relação Estrutura-Atividade
description Universidade Federal do Ceará. BioMol – Laboratório. Departamento de Bioquímica e Biologia Molecular. Fortaleza, CE, Brasil.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2014-03-24T17:08:26Z
dc.date.available.fl_str_mv 2014-03-24T17:08:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAVADA, B. et al. Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins. Current Protein and Peptide Science, v. 2, p. 123-135, 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7439
dc.identifier.issn.none.fl_str_mv 1389-2037
identifier_str_mv CAVADA, B. et al. Revisiting proteus: do minor changes in lectin structure matter in biological activity? Lessons from and potential biotechnological uses of the Diocleinae subtribe lectins. Current Protein and Peptide Science, v. 2, p. 123-135, 2001.
1389-2037
url https://www.arca.fiocruz.br/handle/icict/7439
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Science Publishers Ltd.
publisher.none.fl_str_mv Bentham Science Publishers Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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