Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/2435 |
Resumo: | p.299-303 |
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Silva, Maria Betânia S.Andrade, Tarcísio Matos deSilva, Luciano K.Rodart, Itatiana F.Lopes, Gildete BarretoCarmo, Theomira Mauadie AzevedoZarife, Maria Alice Sant'annaDourado, Maria Inês CostaReis, Mitermayer GSilva, Maria Betânia S.Andrade, Tarcísio Matos deSilva, Luciano K.Rodart, Itatiana F.Lopes, Gildete BarretoCarmo, Theomira Mauadie AzevedoZarife, Maria Alice Sant'annaDourado, Maria Inês CostaReis, Mitermayer G2011-08-30T19:24:23Z2011-08-30T19:24:23Z2010-050074-0276http://www.repositorio.ufba.br/ri/handle/ri/2435105(3): 299-303p.299-303Hepatitis C virus (HCV) is the major infectious disease agent among injecting drug users (IDUs), with seroprevalence ranging from 50-90%. In this paper, serological and virological parameters were investigated among 194 IDUs, 94 ex-IDUs and 95 non-IDUs that were sampled by the “snowball” technique in three localities renowned for both intense drug use and trafficking activities in Salvador, Brazil. The majority of the participants were male, but sex and mean age differed significantly between IDUs/ex-IDUs and non-IDUs (p < 0.05). Anti-HCV screening revealed that 35.6%, 29.8% and 5.3% of samples from IDUs, ex-IDUs and non-IDUs, respectively, were seropositive. HCV-RNA detection confirmed that the prevalence of infection was 29.4%, 21.3% and 5.3% for IDUs, ex-IDUs and non-IDUs, respectively. Genotyping analysis among IDUs/ex-IDUs determined that 76.9% were infected with genotype 1, 18.5% with genotype 3 and 4.6% with a mixed genotype; this result differed significantly from non-IDUs, where genotype 3 was the most frequent (60%), followed by genotype 1 (20%) and a mixed genotype (20%). We report a significantly higher prevalence of HCV infection in IDUs/ex-IDUs compared to the control group (p < 0.001). Although the sample size of our study was small, the differences in HCV genotype distribution reported herein for IDUs/ex-IDUs and non-IDUs warrant further investigation.Submitted by Rigaud Andréa (andrearigaud16@yahoo.com.br) on 2011-08-30T19:24:23Z No. of bitstreams: 1 repos2010.31.pdf: 413363 bytes, checksum: a8c6989d55ec56c06a1517aa8dac3638 (MD5)Made available in DSpace on 2011-08-30T19:24:23Z (GMT). No. of bitstreams: 1 repos2010.31.pdf: 413363 bytes, checksum: a8c6989d55ec56c06a1517aa8dac3638 (MD5) Previous issue date: 2010-05Rio de JaneiroFiocruzHCVinjecting drug usersHCV genotypesprevalenceBrazilPrevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, BrazilMem Inst Oswaldo Cruzinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALrepos2010.31.pdfrepos2010.31.pdfapplication/pdf413363https://repositorio.ufba.br/bitstream/ri/2435/1/repos2010.31.pdfa8c6989d55ec56c06a1517aa8dac3638MD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/2435/2/license.txt4290e29d3455da88aba9abb498ed3151MD52TEXTrepos2010.31.pdf.txtrepos2010.31.pdf.txtExtracted texttext/plain26848https://repositorio.ufba.br/bitstream/ri/2435/3/repos2010.31.pdf.txt0cbe3c9518122c1e2cb72102f0fc6eaaMD53ri/24352022-07-05 14:03:44.021oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:44Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil |
| dc.title.alternative.pt_BR.fl_str_mv |
Mem Inst Oswaldo Cruz |
| title |
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil |
| spellingShingle |
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil Silva, Maria Betânia S. HCV injecting drug users HCV genotypes prevalence Brazil |
| title_short |
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil |
| title_full |
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil |
| title_fullStr |
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil |
| title_full_unstemmed |
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil |
| title_sort |
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil |
| author |
Silva, Maria Betânia S. |
| author_facet |
Silva, Maria Betânia S. Andrade, Tarcísio Matos de Silva, Luciano K. Rodart, Itatiana F. Lopes, Gildete Barreto Carmo, Theomira Mauadie Azevedo Zarife, Maria Alice Sant'anna Dourado, Maria Inês Costa Reis, Mitermayer G |
| author_role |
author |
| author2 |
Andrade, Tarcísio Matos de Silva, Luciano K. Rodart, Itatiana F. Lopes, Gildete Barreto Carmo, Theomira Mauadie Azevedo Zarife, Maria Alice Sant'anna Dourado, Maria Inês Costa Reis, Mitermayer G |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Maria Betânia S. Andrade, Tarcísio Matos de Silva, Luciano K. Rodart, Itatiana F. Lopes, Gildete Barreto Carmo, Theomira Mauadie Azevedo Zarife, Maria Alice Sant'anna Dourado, Maria Inês Costa Reis, Mitermayer G Silva, Maria Betânia S. Andrade, Tarcísio Matos de Silva, Luciano K. Rodart, Itatiana F. Lopes, Gildete Barreto Carmo, Theomira Mauadie Azevedo Zarife, Maria Alice Sant'anna Dourado, Maria Inês Costa Reis, Mitermayer G |
| dc.subject.por.fl_str_mv |
HCV injecting drug users HCV genotypes prevalence Brazil |
| topic |
HCV injecting drug users HCV genotypes prevalence Brazil |
| description |
p.299-303 |
| publishDate |
2010 |
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2010-05 |
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2011-08-30T19:24:23Z |
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2011-08-30T19:24:23Z |
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0074-0276 |
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105(3): 299-303 |
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Fiocruz |
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