Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil

Detalhes bibliográficos
Autor(a) principal: Alvardo-Mora, Mónica V.
Data de Publicação: 2013
Outros Autores: Lima, Livia S. Botelho, Santana, Rubia A., Sitnik, Roberta, Ferreira, Paulo Abrão, Mello, Francisco do Amaral, Mangueira, Cristovão P., Carrilho, Flair J., Pinho, João R. Rebello
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11767
Resumo: Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil.
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spelling Alvardo-Mora, Mónica V.Lima, Livia S. BotelhoSantana, Rubia A.Sitnik, RobertaFerreira, Paulo AbrãoMello, Francisco do AmaralMangueira, Cristovão P.Carrilho, Flair J.Pinho, João R. Rebello2015-09-21T17:25:43Z2015-09-21T17:25:43Z2013ALVARADO-MORA, Mónica V.; Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil. BMC Research Notes, v.6, n.423, 5p, 2013.1756-0500https://www.arca.fiocruz.br/handle/icict/1176710.1186/1756-0500-6-423engBioMed CentralBrasilHepatitis BBrazilBayesian analysisHepatite BTeorema de BayesDistribution of hepatitis B virus subgenotype F2a in São Paulo, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil.Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil.Albert Einstein Medicina Diagnóstica. São Paulo, SP, Brasil.Albert Einstein Medicina Diagnóstica. São Paulo, SP, Brasil.Universidade Federal de São Paulo. UNIFESP. São Paulo, SP, Braisl.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Albert Einstein Medicina Diagnóstica. São Paulo, SP, Brasil.Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil.Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil / Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil / Albert Einstein Medicina Diagnóstica. São Paulo, SP, Brasil.Background: HBV genotype F is primarily found in indigenous populations from South America and is classified in four subgenotypes (F1 to F4). Subgenotype F2a is the most common in Brazil among genotype F cases. The aim of this study was to characterize HBV genotype F2a circulating in 16 patients from São Paulo, Brazil. Samples were collected between 2006 and 2012 and sent to Hospital Israelita Albert Einstein. A fragment of 1306 bp partially comprising HBsAg and DNA polymerase coding regions was amplified and sequenced. Viral sequences were genotyped by phylogenetic analysis using reference sequences from GenBank (n=198), including 80 classified as subgenotype F2a. Bayesian Markov chain Monte Carlo simulation implemented in BEAST v.1.5.4 was applied to obtain the best possible estimates using the model of nucleotide substitutions GTR+G+I. Findings: It were identified three groups of sequences of subgenotype F2a: 1) 10 sequences from São Paulo state; 2) 3 sequences from Rio de Janeiro and one from São Paulo states; 3) 8 sequences from the West Amazon Basin. Conclusions: These results showing for the first time the distribution of F2a subgenotype in Brazil. The spreading and the dynamic of subgenotype F2a in Brazil requires the study of a higher number of samples from different regions as it is unfold in almost all Brazilian populations studied so far. We cannot infer with certainty the origin of these different groups due to the lack of available sequences. Nevertheless, our data suggest that the common origin of these groups probably occurred a long time ago.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11767/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALfrancisco_mello_etal_IOC-2013.pdfapplication/pdf872135https://www.arca.fiocruz.br/bitstream/icict/11767/2/francisco_mello_etal_IOC-2013.pdf0a4e36efac45705b3f236dca9ba255c0MD52TEXTfrancisco_mello_etal_IOC-2013.pdf.txtfrancisco_mello_etal_IOC-2013.pdf.txtExtracted texttext/plain20851https://www.arca.fiocruz.br/bitstream/icict/11767/3/francisco_mello_etal_IOC-2013.pdf.txtb8b06255e4821d5d8db01319dd34c271MD53icict/117672022-06-24 12:17:33.139oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil
title Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil
spellingShingle Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil
Alvardo-Mora, Mónica V.
Brasil
Hepatitis B
Brazil
Bayesian analysis
Hepatite B
Teorema de Bayes
title_short Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil
title_full Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil
title_fullStr Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil
title_full_unstemmed Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil
title_sort Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil
author Alvardo-Mora, Mónica V.
author_facet Alvardo-Mora, Mónica V.
Lima, Livia S. Botelho
Santana, Rubia A.
Sitnik, Roberta
Ferreira, Paulo Abrão
Mello, Francisco do Amaral
Mangueira, Cristovão P.
Carrilho, Flair J.
Pinho, João R. Rebello
author_role author
author2 Lima, Livia S. Botelho
Santana, Rubia A.
Sitnik, Roberta
Ferreira, Paulo Abrão
Mello, Francisco do Amaral
Mangueira, Cristovão P.
Carrilho, Flair J.
Pinho, João R. Rebello
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alvardo-Mora, Mónica V.
Lima, Livia S. Botelho
Santana, Rubia A.
Sitnik, Roberta
Ferreira, Paulo Abrão
Mello, Francisco do Amaral
Mangueira, Cristovão P.
Carrilho, Flair J.
Pinho, João R. Rebello
dc.subject.other.pt_BR.fl_str_mv Brasil
topic Brasil
Hepatitis B
Brazil
Bayesian analysis
Hepatite B
Teorema de Bayes
dc.subject.en.pt_BR.fl_str_mv Hepatitis B
Brazil
Bayesian analysis
dc.subject.decs.pt_BR.fl_str_mv Hepatite B
Teorema de Bayes
description Universidade de São Paulo. Escola de Medicina. Departamento de Gastroenterologia. Laboratório de Gastroenterologia e Hepatologia Tropical. São Paulo, SP, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2015-09-21T17:25:43Z
dc.date.available.fl_str_mv 2015-09-21T17:25:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALVARADO-MORA, Mónica V.; Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil. BMC Research Notes, v.6, n.423, 5p, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11767
dc.identifier.issn.pt_BR.fl_str_mv 1756-0500
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/1756-0500-6-423
identifier_str_mv ALVARADO-MORA, Mónica V.; Distribution of hepatitis B virus subgenotype F2a in São Paulo, Brazil. BMC Research Notes, v.6, n.423, 5p, 2013.
1756-0500
10.1186/1756-0500-6-423
url https://www.arca.fiocruz.br/handle/icict/11767
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dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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