Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58408 |
Resumo: | This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo, Universidade de São Paulo-bioMérieux S.A. – PITE2 ARBOBIOS [2016/20597-0 to E.C.S and G.P. B]; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro [E-26/202.930/2016 to A.M.B.F; E26/202.826/2018 and E-210.012/2020 to A.T.R.V] and Conselho Nacional de Desenvolvimento Cientı´fico e Tecnológico [303170/2017-4 to A.T.R.V]; Fundac¸ão Faculdade de Medicina da Universidade de São Paulo [206.706 to M.S.R; 205.383 to E.RM.; 205.855 to G.M.P]; Fundação de Amparo à Pesquisa do Estado de São Paulo [2018/09971-2 to M.F.C]; Wellcome Trust and Royal Society Sir Henry Dale Fellowship [204311/Z/16/Z to N.R.F], Medical Research Council-Fundação de Amparo à Pesquisa do Estado de São Paulo - CADDE partnership award [MR/S0195/1 and FAPESP 18/14389-0 to N. R.F];. M.F.C. and G.P.B received salaries from bioMerieux S.A. during this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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Lázari, Carolina dos SantosRamundo, Mariana Severoten-Caten, FelipeBressan, Clarisse S.Filippis, Ana Maria Bispo deManuli, Erika ReginaMoraes, Isabella dePereira, Geovana MariaCôrtes, Marina FarrelCandido, Darlan da SilvaGerber, Alexandra L.Guimarães, Ana PaulaFaria, Nuno RodriguesNakaya, Helder I.Vasconcelos, Ana Tereza R.Brasil, PatríciaParanhos-Baccalà, GláuciaSabino, Ester Cerdeira2023-05-15T23:10:44Z2023-05-15T23:10:44Z2023LÁZARI, Carolina dos Santos et al. Clinical markers of post-Chikungunya chronic inflammatory joint disease: a Brazilian cohort. PLoS Neglected Tropical Diseases, v. 17, n. 1, p. 1-17, Jan. 2023.1935-2727https://www.arca.fiocruz.br/handle/icict/5840810.1371/journal.pntd.00110371935-2735This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo, Universidade de São Paulo-bioMérieux S.A. – PITE2 ARBOBIOS [2016/20597-0 to E.C.S and G.P. B]; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro [E-26/202.930/2016 to A.M.B.F; E26/202.826/2018 and E-210.012/2020 to A.T.R.V] and Conselho Nacional de Desenvolvimento Cientı´fico e Tecnológico [303170/2017-4 to A.T.R.V]; Fundac¸ão Faculdade de Medicina da Universidade de São Paulo [206.706 to M.S.R; 205.383 to E.RM.; 205.855 to G.M.P]; Fundação de Amparo à Pesquisa do Estado de São Paulo [2018/09971-2 to M.F.C]; Wellcome Trust and Royal Society Sir Henry Dale Fellowship [204311/Z/16/Z to N.R.F], Medical Research Council-Fundação de Amparo à Pesquisa do Estado de São Paulo - CADDE partnership award [MR/S0195/1 and FAPESP 18/14389-0 to N. R.F];. M.F.C. and G.P.B received salaries from bioMerieux S.A. during this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brazil / Fleury Medicina e Saúde. São Paulo, SP, Brazil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brazil / Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brazil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brazil / Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brazil / Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brazil / Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brazil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brazil / Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brazil / Open Innovation and Partnerships, bioMérieux SA. Lyon, France.University of Oxford. Department of Zoology. Oxford, United Kingdom.Laboratório Nacional de Computação Científica. Petrópolis, RJ, Brazil.Laboratório Nacional de Computação Científica. Petrópolis, RJ, Brazil.University of Oxford. Department of Zoology. Oxford, United Kingdom / MRC Centre of Global Infectious Disease Analysis. Jameel Institute for Disease and Emergency Analytics. Imperial College of London. London, United Kingdom.Universidade de São Paulo. Scientific Platform Pasteur. São Paulo, SP, Brazil / Hospital Israelita Albert Einstein. São Paulo, SP, Brazil / Instituto Todos pela Saúde. São Paulo, SP, Brazil.Laboratório Nacional de Computação Científica. Petrópolis, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Open Innovation and Partnerships, bioMérieux SA. Lyon, France.Universidade de São Paulo. Faculdade de Medicina. Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brazil / Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brazil.Background: Chikungunya-fever (CHIKF) remains a public health major issue. It is clinically divided into three phases: acute, post-acute and chronic. Chronic cases correspond to 25-40% individuals and, though most of them are characterized by long-lasting arthralgia alone, many of them exhibit persistent or recurrent inflammatory signs that define post-Chikungunya chronic inflammatory joint disease (pCHIKV-CIJD). We aimed to identify early clinical markers of evolution to pCHIKV-CIJD during acute and post-acute phases. Methodology/principal findings: We studied a prospective cohort of CHIKF-confirmed volunteers with longitudinal clinical data collection from symptoms onset up to 90 days, including a 21-day visit (D21). Of 169 patients with CHIKF, 86 (50.9%) completed the follow-up, from whom 39 met clinical criteria for pCHIKV-CIJD (45.3%). The relative risk of chronification was higher in women compared to men (RR = 1.52; 95% CI = 1.15-1.99; FDR = 0.03). None of the symptoms or signs presented at D0 behaved as an early predictor of pCHIKV-CIJD, while being symptomatic at D21 was a risk factor for chronification (RR = 1.31; 95% CI = 1.09-1.55; FDR = 0.03). Significance was also observed for joint pain (RR = 1.35; 95% CI = 1.12-1.61; FDR = 0.02), reported edema (RR = 3.61; 95% CI = 1.44-9.06; FDR = 0.03), reported hand and/or feet small joints edema (RR = 4.22; 95% CI = 1.51-11.78; FDR = 0.02), and peri-articular edema observed during physical examination (RR = 2.89; 95% CI = 1.58-5.28; FDR = 0.002). Furthermore, patients with no findings in physical examination at D21 were at lower risk of chronic evolution (RR = 0.41, 95% CI = 0.24-0.70, FDR = 0.01). Twenty-nine pCHIKV-CIJD patients had abnormal articular ultrasonography (90.6% of the examined). The most common findings were synovitis (65.5%) and joint effusion (58.6%). Conclusion: This cohort has provided important insights into the prognostic evaluation of CHIKF. Symptomatic sub-acute disease is a relevant predictor of evolution to chronic arthritis with synovitis, drawing attention to joint pain, edema, multiple articular involvement including small hand and feet joints as risk factors for chronification beyond three months, especially in women. Future studies are needed to accomplish the identification of accurate and early biomarkers of poor clinical prognosis, which would allow better understanding of the disease's evolution and improve patients' management, modifying CHIKF burden on global public health.engPublic Library of ScienceClinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohortinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChikungunyaChikungunya-fever (CHIKF)Chronic inflammatory joint diseaseCohortinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.en_US.fl_str_mv |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort |
| title |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort |
| spellingShingle |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort Lázari, Carolina dos Santos Chikungunya Chikungunya-fever (CHIKF) Chronic inflammatory joint disease Cohort |
| title_short |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort |
| title_full |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort |
| title_fullStr |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort |
| title_full_unstemmed |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort |
| title_sort |
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort |
| author |
Lázari, Carolina dos Santos |
| author_facet |
Lázari, Carolina dos Santos Ramundo, Mariana Severo ten-Caten, Felipe Bressan, Clarisse S. Filippis, Ana Maria Bispo de Manuli, Erika Regina Moraes, Isabella de Pereira, Geovana Maria Côrtes, Marina Farrel Candido, Darlan da Silva Gerber, Alexandra L. Guimarães, Ana Paula Faria, Nuno Rodrigues Nakaya, Helder I. Vasconcelos, Ana Tereza R. Brasil, Patrícia Paranhos-Baccalà, Gláucia Sabino, Ester Cerdeira |
| author_role |
author |
| author2 |
Ramundo, Mariana Severo ten-Caten, Felipe Bressan, Clarisse S. Filippis, Ana Maria Bispo de Manuli, Erika Regina Moraes, Isabella de Pereira, Geovana Maria Côrtes, Marina Farrel Candido, Darlan da Silva Gerber, Alexandra L. Guimarães, Ana Paula Faria, Nuno Rodrigues Nakaya, Helder I. Vasconcelos, Ana Tereza R. Brasil, Patrícia Paranhos-Baccalà, Gláucia Sabino, Ester Cerdeira |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lázari, Carolina dos Santos Ramundo, Mariana Severo ten-Caten, Felipe Bressan, Clarisse S. Filippis, Ana Maria Bispo de Manuli, Erika Regina Moraes, Isabella de Pereira, Geovana Maria Côrtes, Marina Farrel Candido, Darlan da Silva Gerber, Alexandra L. Guimarães, Ana Paula Faria, Nuno Rodrigues Nakaya, Helder I. Vasconcelos, Ana Tereza R. Brasil, Patrícia Paranhos-Baccalà, Gláucia Sabino, Ester Cerdeira |
| dc.subject.en.en_US.fl_str_mv |
Chikungunya Chikungunya-fever (CHIKF) Chronic inflammatory joint disease Cohort |
| topic |
Chikungunya Chikungunya-fever (CHIKF) Chronic inflammatory joint disease Cohort |
| description |
This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo, Universidade de São Paulo-bioMérieux S.A. – PITE2 ARBOBIOS [2016/20597-0 to E.C.S and G.P. B]; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro [E-26/202.930/2016 to A.M.B.F; E26/202.826/2018 and E-210.012/2020 to A.T.R.V] and Conselho Nacional de Desenvolvimento Cientı´fico e Tecnológico [303170/2017-4 to A.T.R.V]; Fundac¸ão Faculdade de Medicina da Universidade de São Paulo [206.706 to M.S.R; 205.383 to E.RM.; 205.855 to G.M.P]; Fundação de Amparo à Pesquisa do Estado de São Paulo [2018/09971-2 to M.F.C]; Wellcome Trust and Royal Society Sir Henry Dale Fellowship [204311/Z/16/Z to N.R.F], Medical Research Council-Fundação de Amparo à Pesquisa do Estado de São Paulo - CADDE partnership award [MR/S0195/1 and FAPESP 18/14389-0 to N. R.F];. M.F.C. and G.P.B received salaries from bioMerieux S.A. during this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| publishDate |
2023 |
| dc.date.accessioned.fl_str_mv |
2023-05-15T23:10:44Z |
| dc.date.available.fl_str_mv |
2023-05-15T23:10:44Z |
| dc.date.issued.fl_str_mv |
2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
LÁZARI, Carolina dos Santos et al. Clinical markers of post-Chikungunya chronic inflammatory joint disease: a Brazilian cohort. PLoS Neglected Tropical Diseases, v. 17, n. 1, p. 1-17, Jan. 2023. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/58408 |
| dc.identifier.issn.en_US.fl_str_mv |
1935-2727 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0011037 |
| dc.identifier.eissn.none.fl_str_mv |
1935-2735 |
| identifier_str_mv |
LÁZARI, Carolina dos Santos et al. Clinical markers of post-Chikungunya chronic inflammatory joint disease: a Brazilian cohort. PLoS Neglected Tropical Diseases, v. 17, n. 1, p. 1-17, Jan. 2023. 1935-2727 10.1371/journal.pntd.0011037 1935-2735 |
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https://www.arca.fiocruz.br/handle/icict/58408 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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5a560609d32a3863062d77ff32785d58 0a95520d09e7116d6beb629073afbcdd |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009138974720000 |