Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46884 |
Resumo: | Brazilian National Council for Scientific and Technological Development (Grants 400830/2013-2 and 440891/2016-7 to GSR, and scholarships to LBT, UK, MGR and GSR) |
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Silva, Monaíse M. O.Kikuti, MarianaAnjos, Rosângela O.Portilho, Moyra M.Santos, Viviane C.Gonçalves, Thaiza S. F.Tauro, Laura B.Moreira, Patrícia S. S.Nascimento, Leile C. JacobSantana, Perla M.Campos, Gúbio S.Siqueira, André M.Kitrona, UrielReis, Mitermayer Galvão dosRibeiro, Guilherme de Sousa2021-04-26T11:37:04Z2021-04-26T11:37:04Z2021SILVA, Monaíse M. O. et al. Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil. International Journal of Infectious Diseases, v. 105, p. 608–616, 1 Apr. 2021.1201-9712https://www.arca.fiocruz.br/handle/icict/4688410.1016/j.ijid.2021.03.003Brazilian National Council for Scientific and Technological Development (Grants 400830/2013-2 and 440891/2016-7 to GSR, and scholarships to LBT, UK, MGR and GSR)Bahia Foundation for Research Support (PET0026/2013, APP0044/2016 and PET0022/2016 to GSR, and scholarship to MMOS)Coordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education (88881.130749/2016-01 to GSR and scholarship to MK)Department of Science and Technology, Secretariat of Science, Technology and Strategic Inputs, Brazilian Ministry of HealthFederal University of BahiaFundação Oswaldo CruzREPLICK (Clinical and Applied Research in Chikungunya)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva, Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Biologia Subtropical. Consejo Nacional de Investigaciones Científicas y Técnicas. Puerto Iguazú, Argentina.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Emory University. Atlanta, GA, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Yale University. Yale School of Public Health. New Haven, CT, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Objectives: To investigate risk factors for persistent arthralgia in patients with chikungunya, and describe its impact on daily activities. Methods: From September 2014 to July 2016, a surveillance study enrolled patients with acute febrile illness in Salvador, Brazil, and detected those with chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. Telephone follow-ups were performed to ascertain the progression of disease. Results: Of 153 followed cases, 65 (42.5%) reported chronic arthralgia that lasted >3 months, and 47 (30.7%) were still symptomatic at the time of the interview (approximately 1.5 years after symptom onset). Limitations in daily activities and mental distress were reported by 93.8% and 61.5% of those with chronic arthralgia, respectively. Female sex [risk ratio (RR) 1.79, 95% confidence interval (CI) 1.95–2.69] and age (RR 1.02 for each 1-year increase, 95% CI 1.01–1.03) were independent risk factors for chronic arthralgia. Chronic arthralgia was not associated with co-infection with dengue virus (RR 0.97, 95% CI 0.48–1.94) or chikungunya viral load at diagnosis (median chikungunya virus RNA of 5.60 and 5.52 log10 copies/mL for those with and without chronic arthralgia, respectively; P = 0.75). Conclusions: These findings reinforce the high frequency of chronic chikungunya arthralgia, and highlight the substantial disability associated with the persistence of pain. Development of novel strategies to mitigate the transmission of chikungunya virus and to provide long-term medical assistance for patients with chikungunya are needed urgently.engElsevierVírus ChikungunyaArtralgia crônicaCoorteFator de riscoIncapacidadeChikungunya virusChronic arthralgiaCohortRisk factorDisabilityRisk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46884/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva, Monaíse M.O. Risk of chronic....pdfSilva, Monaíse M.O. 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| dc.title.en.fl_str_mv |
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil |
| title |
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil |
| spellingShingle |
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil Silva, Monaíse M. O. Vírus Chikungunya Artralgia crônica Coorte Fator de risco Incapacidade Chikungunya virus Chronic arthralgia Cohort Risk factor Disability |
| title_short |
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil |
| title_full |
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil |
| title_fullStr |
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil |
| title_full_unstemmed |
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil |
| title_sort |
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil |
| author |
Silva, Monaíse M. O. |
| author_facet |
Silva, Monaíse M. O. Kikuti, Mariana Anjos, Rosângela O. Portilho, Moyra M. Santos, Viviane C. Gonçalves, Thaiza S. F. Tauro, Laura B. Moreira, Patrícia S. S. Nascimento, Leile C. Jacob Santana, Perla M. Campos, Gúbio S. Siqueira, André M. Kitrona, Uriel Reis, Mitermayer Galvão dos Ribeiro, Guilherme de Sousa |
| author_role |
author |
| author2 |
Kikuti, Mariana Anjos, Rosângela O. Portilho, Moyra M. Santos, Viviane C. Gonçalves, Thaiza S. F. Tauro, Laura B. Moreira, Patrícia S. S. Nascimento, Leile C. Jacob Santana, Perla M. Campos, Gúbio S. Siqueira, André M. Kitrona, Uriel Reis, Mitermayer Galvão dos Ribeiro, Guilherme de Sousa |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Monaíse M. O. Kikuti, Mariana Anjos, Rosângela O. Portilho, Moyra M. Santos, Viviane C. Gonçalves, Thaiza S. F. Tauro, Laura B. Moreira, Patrícia S. S. Nascimento, Leile C. Jacob Santana, Perla M. Campos, Gúbio S. Siqueira, André M. Kitrona, Uriel Reis, Mitermayer Galvão dos Ribeiro, Guilherme de Sousa |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus Chikungunya Artralgia crônica Coorte Fator de risco Incapacidade |
| topic |
Vírus Chikungunya Artralgia crônica Coorte Fator de risco Incapacidade Chikungunya virus Chronic arthralgia Cohort Risk factor Disability |
| dc.subject.en.en.fl_str_mv |
Chikungunya virus Chronic arthralgia Cohort Risk factor Disability |
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Brazilian National Council for Scientific and Technological Development (Grants 400830/2013-2 and 440891/2016-7 to GSR, and scholarships to LBT, UK, MGR and GSR) |
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2021 |
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2021-04-26T11:37:04Z |
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2021-04-26T11:37:04Z |
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2021 |
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SILVA, Monaíse M. O. et al. Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil. International Journal of Infectious Diseases, v. 105, p. 608–616, 1 Apr. 2021. |
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https://www.arca.fiocruz.br/handle/icict/46884 |
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1201-9712 |
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10.1016/j.ijid.2021.03.003 |
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SILVA, Monaíse M. O. et al. Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil. International Journal of Infectious Diseases, v. 105, p. 608–616, 1 Apr. 2021. 1201-9712 10.1016/j.ijid.2021.03.003 |
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