Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?

Detalhes bibliográficos
Autor(a) principal: Ramos, Grazielle Viana
Data de Publicação: 2018
Outros Autores: Japiassú, André Miguel, Bozza, Fernando Augusto, Guaraldo, Lusiele
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31569
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.
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spelling Ramos, Grazielle VianaJapiassú, André MiguelBozza, Fernando AugustoGuaraldo, Lusiele2019-02-12T13:26:59Z2019-02-12T13:26:59Z2018RAMOS, Grazielle Viana et al. Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool? Clinics, v. 73, p. 1-4, 2018.1807-5932https://www.arca.fiocruz.br/handle/icict/3156910.6061/clinics/2018/e1481980-5322engFaculdade de Medicina / USPPreventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.OBJECTIVES: The aim of this study was to develop a strategy to identify adverse drug events associated with drug-drug interactions by analyzing the prescriptions of critically ill patients. METHODS: This retrospective study included HIV/AIDS patients who were admitted to an intensive care unit between November 2006 and September 2008. Data were collected in two stages. In the first stage, three prescriptions administered throughout the entire duration of these patients’ hospitalization were reviewed, with the Micromedex database used to search for potential drug-drug interactions. In the second stage, a search for adverse drug events in all available medical, nursing and laboratory records was performed. The probability that a drug-drug interaction caused each adverse drug events was assessed using the Naranjo algorithm. RESULTS: A total of 186 drug prescriptions of 62 HIV/AIDS patients were analyzed. There were 331 potential drug-drug interactions, and 9% of these potential interactions resulted in adverse drug events in 16 patients; these adverse drug events included treatment failure (16.7%) and adverse reactions (83.3%). Most of the adverse drug reactions were classified as possible based on the Naranjo algorithm. CONCLUSIONS: The approach used in this study allowed for the detection of adverse drug events related to 9% of the potential drug-drug interactions that were identified; these adverse drug events affected 26% of the study population. With the monitoring of adverse drug events based on prescriptions, a combination of the evaluation of potential drug-drug interactions by clinical pharmacy services and the monitoring of critically ill patients is an effective strategy that can be used as a complementary tool for safety assessments and the prevention of adverse drug events.Drug-related side effects and adverse reactionsDrug interactionsIntensive care unitsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
title Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
spellingShingle Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
Ramos, Grazielle Viana
Drug-related side effects and adverse reactions
Drug interactions
Intensive care units
title_short Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
title_full Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
title_fullStr Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
title_full_unstemmed Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
title_sort Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool?
author Ramos, Grazielle Viana
author_facet Ramos, Grazielle Viana
Japiassú, André Miguel
Bozza, Fernando Augusto
Guaraldo, Lusiele
author_role author
author2 Japiassú, André Miguel
Bozza, Fernando Augusto
Guaraldo, Lusiele
author2_role author
author
author
dc.contributor.author.fl_str_mv Ramos, Grazielle Viana
Japiassú, André Miguel
Bozza, Fernando Augusto
Guaraldo, Lusiele
dc.subject.en.pt_BR.fl_str_mv Drug-related side effects and adverse reactions
Drug interactions
Intensive care units
topic Drug-related side effects and adverse reactions
Drug interactions
Intensive care units
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto D’Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-12T13:26:59Z
dc.date.available.fl_str_mv 2019-02-12T13:26:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RAMOS, Grazielle Viana et al. Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool? Clinics, v. 73, p. 1-4, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31569
dc.identifier.issn.pt_BR.fl_str_mv 1807-5932
dc.identifier.doi.none.fl_str_mv 10.6061/clinics/2018/e148
dc.identifier.eissn.none.fl_str_mv 1980-5322
identifier_str_mv RAMOS, Grazielle Viana et al. Preventable adverse drug events in critically ill HIV patients: is the detection of potential drug-drug interactions a useful tool? Clinics, v. 73, p. 1-4, 2018.
1807-5932
10.6061/clinics/2018/e148
1980-5322
url https://www.arca.fiocruz.br/handle/icict/31569
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Faculdade de Medicina / USP
publisher.none.fl_str_mv Faculdade de Medicina / USP
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/31569/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/31569/2/ve_Ramos_Grazielle_etal_INI_2018.pdf
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