Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?

Detalhes bibliográficos
Autor(a) principal: Ramos, Grazielle Viana
Data de Publicação: 2018
Outros Autores: Japiassú, André Miguel, Bozza, Fernando Augusto, Guaraldo, Lusiele
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/144529
Resumo: OBJECTIVES: The aim of this study was to develop a strategy to identify adverse drug events associated with drug-drug interactions by analyzing the prescriptions of critically ill patients. METHODS: This retrospective study included HIV/AIDS patients who were admitted to an intensive care unit between November 2006 and September 2008. Data were collected in two stages. In the first stage, three prescriptions administered throughout the entire duration of these patients’ hospitalization were reviewed, with the Micromedex database used to search for potential drug-drug interactions. In the second stage, a search for adverse drug events in all available medical, nursing and laboratory records was performed. The probability that a drug-drug interaction caused each adverse drug events was assessed using the Naranjo algorithm. RESULTS: A total of 186 drug prescriptions of 62 HIV/AIDS patients were analyzed. There were 331 potential drug-drug interactions, and 9% of these potential interactions resulted in adverse drug events in 16 patients; these adverse drug events included treatment failure (16.7%) and adverse reactions (83.3%). Most of the adverse drug reactions were classified as possible based on the Naranjo algorithm. CONCLUSIONS: The approach used in this study allowed for the detection of adverse drug events related to 9% of the potential drug-drug interactions that were identified; these adverse drug events affected 26% of the study population. With the monitoring of adverse drug events based on prescriptions, a combination of the evaluation of potential drug-drug interactions by clinical pharmacy services and the monitoring of critically ill patients is an effective strategy that can be used as a complementary tool for safety assessments and the prevention of adverse drug events.
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spelling Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?Drug-Related Side Effects and Adverse ReactionsDrug InteractionsIntensive Care UnitsOBJECTIVES: The aim of this study was to develop a strategy to identify adverse drug events associated with drug-drug interactions by analyzing the prescriptions of critically ill patients. METHODS: This retrospective study included HIV/AIDS patients who were admitted to an intensive care unit between November 2006 and September 2008. Data were collected in two stages. In the first stage, three prescriptions administered throughout the entire duration of these patients’ hospitalization were reviewed, with the Micromedex database used to search for potential drug-drug interactions. In the second stage, a search for adverse drug events in all available medical, nursing and laboratory records was performed. The probability that a drug-drug interaction caused each adverse drug events was assessed using the Naranjo algorithm. RESULTS: A total of 186 drug prescriptions of 62 HIV/AIDS patients were analyzed. There were 331 potential drug-drug interactions, and 9% of these potential interactions resulted in adverse drug events in 16 patients; these adverse drug events included treatment failure (16.7%) and adverse reactions (83.3%). Most of the adverse drug reactions were classified as possible based on the Naranjo algorithm. CONCLUSIONS: The approach used in this study allowed for the detection of adverse drug events related to 9% of the potential drug-drug interactions that were identified; these adverse drug events affected 26% of the study population. With the monitoring of adverse drug events based on prescriptions, a combination of the evaluation of potential drug-drug interactions by clinical pharmacy services and the monitoring of critically ill patients is an effective strategy that can be used as a complementary tool for safety assessments and the prevention of adverse drug events.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/14452910.6061/clinics/2018/e148Clinics; Vol. 73 (2018); e148Clinics; v. 73 (2018); e148Clinics; Vol. 73 (2018); e1481980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/144529/138856Copyright (c) 2018 Clinicsinfo:eu-repo/semantics/openAccessRamos, Grazielle VianaJapiassú, André MiguelBozza, Fernando AugustoGuaraldo, Lusiele2019-05-14T11:48:50Zoai:revistas.usp.br:article/144529Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:50Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?
title Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?
spellingShingle Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?
Ramos, Grazielle Viana
Drug-Related Side Effects and Adverse Reactions
Drug Interactions
Intensive Care Units
title_short Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?
title_full Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?
title_fullStr Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?
title_full_unstemmed Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?
title_sort Preventable adverse drug events in critically ill HIV patients: Is the detection of potential drug-drug interactions a useful tool?
author Ramos, Grazielle Viana
author_facet Ramos, Grazielle Viana
Japiassú, André Miguel
Bozza, Fernando Augusto
Guaraldo, Lusiele
author_role author
author2 Japiassú, André Miguel
Bozza, Fernando Augusto
Guaraldo, Lusiele
author2_role author
author
author
dc.contributor.author.fl_str_mv Ramos, Grazielle Viana
Japiassú, André Miguel
Bozza, Fernando Augusto
Guaraldo, Lusiele
dc.subject.por.fl_str_mv Drug-Related Side Effects and Adverse Reactions
Drug Interactions
Intensive Care Units
topic Drug-Related Side Effects and Adverse Reactions
Drug Interactions
Intensive Care Units
description OBJECTIVES: The aim of this study was to develop a strategy to identify adverse drug events associated with drug-drug interactions by analyzing the prescriptions of critically ill patients. METHODS: This retrospective study included HIV/AIDS patients who were admitted to an intensive care unit between November 2006 and September 2008. Data were collected in two stages. In the first stage, three prescriptions administered throughout the entire duration of these patients’ hospitalization were reviewed, with the Micromedex database used to search for potential drug-drug interactions. In the second stage, a search for adverse drug events in all available medical, nursing and laboratory records was performed. The probability that a drug-drug interaction caused each adverse drug events was assessed using the Naranjo algorithm. RESULTS: A total of 186 drug prescriptions of 62 HIV/AIDS patients were analyzed. There were 331 potential drug-drug interactions, and 9% of these potential interactions resulted in adverse drug events in 16 patients; these adverse drug events included treatment failure (16.7%) and adverse reactions (83.3%). Most of the adverse drug reactions were classified as possible based on the Naranjo algorithm. CONCLUSIONS: The approach used in this study allowed for the detection of adverse drug events related to 9% of the potential drug-drug interactions that were identified; these adverse drug events affected 26% of the study population. With the monitoring of adverse drug events based on prescriptions, a combination of the evaluation of potential drug-drug interactions by clinical pharmacy services and the monitoring of critically ill patients is an effective strategy that can be used as a complementary tool for safety assessments and the prevention of adverse drug events.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/144529
10.6061/clinics/2018/e148
url https://www.revistas.usp.br/clinics/article/view/144529
identifier_str_mv 10.6061/clinics/2018/e148
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/144529/138856
dc.rights.driver.fl_str_mv Copyright (c) 2018 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 73 (2018); e148
Clinics; v. 73 (2018); e148
Clinics; Vol. 73 (2018); e148
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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