Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48042 |
Resumo: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Programa Inova Fiocruz and National Institute of Health (NIH) grant AI136032. C.I.B., V.M.B. and P.S.T.V. are senior investigators of CNPq. P.S.T.V. holds a grant from CNPq for productivity in research (307832/2015-5). |
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Rebouças, AmandaSilva, Thaílla S.Medina, Lilian S.Paredes, Bruno D.Aragão, Luciana S.Borges, Valéria de MatosSchriefer, AlbertVeras, Patrícia Sampaio TavaresBrodskyn, Claudia IdaJuliana Perrone Bezerra de Menezes2021-07-07T18:11:04Z2021-07-07T18:11:04Z2021REBOUÇAS, Amanda et al. Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination. Microorganisms, 2021.2076-2607https://www.arca.fiocruz.br/handle/icict/4804210.3390/microorganisms9061268Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Programa Inova Fiocruz and National Institute of Health (NIH) grant AI136032. C.I.B., V.M.B. and P.S.T.V. are senior investigators of CNPq. P.S.T.V. holds a grant from CNPq for productivity in research (307832/2015-5).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasito-Hospedeiro e Epidemiologia. Salvador, BA, Brasil.Federal University of Bahia. Professor Edgard Santos Hospital. Immunology Service. Salvador, BA, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education, Salvador, BA, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education, Salvador, BA, Brazil /São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education, Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brasil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Federal University of Bahia. Institute of Health Sciences, Department of Bio-Interaction, Salvador, BA, Brazil.Leishmania, an intracellular parasite species, causes lesions on the skin and in the mucosa and internal organs. The dissemination of infected host cells containing Leishmania is crucial to parasite survival and the establishment of infection. Migratory phenomena and the mechanisms underlying the dissemination of Leishmania-infected human dendritic cells (hDCs) remain poorly understood. The present study aimed to investigate differences among factors involved in hDC migration by comparing infection with visceral leishmaniasis (VL) induced by Leishmania infantum with diverse clinical forms of tegumentary leishmaniasis (TL) induced by Leishmania braziliensis or Leishmania amazonensis. Following the infection of hDCs by isolates obtained from patients with different clinical forms of Leishmania, the formation of adhesion complexes, actin polymerization, and CCR7 expression were evaluated. We observed increased hDC migration following infection with isolates of L. infantum (VL), as well as disseminated (DL) and diffuse (DCL) forms of cutaneous leishmaniasis (CL) caused by L. braziliensis and L. amazonensis, respectively. Increased expression of proteins involved in adhesion complex formation and actin polymerization, as well as higher CCR7 expression, were seen in hDCs infected with L. infantum, DL and DCL isolates. Together, our results suggest that hDCs play an important role in the dissemination of Leishmania parasites in the vertebrate host.engMDPICélulas dendríticasInfecçõesLeishmaniaMembrana MucosaLeishmania braziliensisDendritic cellMigrationLeishmaniaDisseminationLeishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Disseminationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/48042/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALRebouças, Amanda Leishmania-induced....pdfRebouças, Amanda Leishmania-induced....pdfapplication/pdf11156289https://www.arca.fiocruz.br/bitstream/icict/48042/2/Rebou%c3%a7as%2c%20Amanda%20%20Leishmania-induced....pdfc175709a1a8ad0a5ebd427b4a0e9aaecMD52TEXTRebouças, Amanda Leishmania-induced....pdf.txtRebouças, Amanda Leishmania-induced....pdf.txtExtracted texttext/plain44864https://www.arca.fiocruz.br/bitstream/icict/48042/3/Rebou%c3%a7as%2c%20Amanda%20%20Leishmania-induced....pdf.txtfb5d47beccfdd61f37e0c661164f38edMD53icict/480422023-03-15 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| dc.title.pt_BR.fl_str_mv |
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination |
| title |
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination |
| spellingShingle |
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination Rebouças, Amanda Células dendríticas Infecções Leishmania Membrana Mucosa Leishmania braziliensis Dendritic cell Migration Leishmania Dissemination |
| title_short |
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination |
| title_full |
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination |
| title_fullStr |
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination |
| title_full_unstemmed |
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination |
| title_sort |
Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination |
| author |
Rebouças, Amanda |
| author_facet |
Rebouças, Amanda Silva, Thaílla S. Medina, Lilian S. Paredes, Bruno D. Aragão, Luciana S. Borges, Valéria de Matos Schriefer, Albert Veras, Patrícia Sampaio Tavares Brodskyn, Claudia Ida Juliana Perrone Bezerra de Menezes |
| author_role |
author |
| author2 |
Silva, Thaílla S. Medina, Lilian S. Paredes, Bruno D. Aragão, Luciana S. Borges, Valéria de Matos Schriefer, Albert Veras, Patrícia Sampaio Tavares Brodskyn, Claudia Ida Juliana Perrone Bezerra de Menezes |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rebouças, Amanda Silva, Thaílla S. Medina, Lilian S. Paredes, Bruno D. Aragão, Luciana S. Borges, Valéria de Matos Schriefer, Albert Veras, Patrícia Sampaio Tavares Brodskyn, Claudia Ida Juliana Perrone Bezerra de Menezes |
| dc.subject.other.pt_BR.fl_str_mv |
Células dendríticas Infecções Leishmania Membrana Mucosa Leishmania braziliensis |
| topic |
Células dendríticas Infecções Leishmania Membrana Mucosa Leishmania braziliensis Dendritic cell Migration Leishmania Dissemination |
| dc.subject.en.pt_BR.fl_str_mv |
Dendritic cell Migration Leishmania Dissemination |
| description |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Programa Inova Fiocruz and National Institute of Health (NIH) grant AI136032. C.I.B., V.M.B. and P.S.T.V. are senior investigators of CNPq. P.S.T.V. holds a grant from CNPq for productivity in research (307832/2015-5). |
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2021 |
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2021-07-07T18:11:04Z |
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2021-07-07T18:11:04Z |
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2021 |
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info:eu-repo/semantics/article |
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REBOUÇAS, Amanda et al. Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination. Microorganisms, 2021. |
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https://www.arca.fiocruz.br/handle/icict/48042 |
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2076-2607 |
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10.3390/microorganisms9061268 |
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REBOUÇAS, Amanda et al. Leishmania-Induced Dendritic Cell Migration and Its Potential Contribution to Parasite Dissemination. Microorganisms, 2021. 2076-2607 10.3390/microorganisms9061268 |
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