The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review

Detalhes bibliográficos
Autor(a) principal: Post, Paulo Roberto
Data de Publicação: 2001
Outros Autores: Carvalho, Ricardo de, Freire, Marcos da Silva, Galler, Ricardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44153
Resumo: Universidade Federal de Pelotas, Campus Universitário. Instituto de Biologia. Departamento de Microbiologia e Parasitologia, Pelotas, RS, Brasil.
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spelling Post, Paulo RobertoCarvalho, Ricardo deFreire, Marcos da SilvaGaller, Ricardo2020-10-23T19:55:49Z2020-10-23T19:55:49Z2001POST, Paulo Roberto et al. The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review, Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 849-857, Aug. 2001.0074-0276https://www.arca.fiocruz.br/handle/icict/4415310.1590/S0074-027620010006000191678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Febre AmarelaVacinaImunizaçãoTensão 17DDLinhagem de vírusYellow feverVaccine17DD strainVirus lineageImmunizationThe Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pelotas, Campus Universitário. Instituto de Biologia. Departamento de Microbiologia e Parasitologia, Pelotas, RS, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.The use of yellow fever (YF) virus 17D strain for vaccine production adapted in Brazil since its introduction in 1937 was reviewed. This was possible due to the availability of official records of vaccine production. The retrieved data highlight the simultaneous use of several serially passaged 17D substrain viruses for both inocula and vaccine preparation that allowed uninterrupted production. Substitution of these substrain viruses became possible with the experience gained during quality control and human vaccination. Post-vaccinal complications in humans and the failure of some viruses in quality control tests (neurovirulence for monkeys) indicated that variables needed to be reduced during vaccine production, leading to the development of the seed lot system. The 17DD substrain, still used today, was the most frequently used substrain and the most reliable in terms of safety and efficacy. For this reason, it is possible to derive an infectious cDNA clone of this substrain combined with production in cell culture that could be used to direct the expression of heterologous antigens and lead to the development of new live vaccines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44153/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPauloRoberto_Post_etal_IOC_2001.pdfPauloRoberto_Post_etal_IOC_2001.pdfapplication/pdf136999https://www.arca.fiocruz.br/bitstream/icict/44153/2/PauloRoberto_Post_etal_IOC_2001.pdf7bd2ec81b926951e280f9187696196c9MD52TEXTPauloRoberto_Post_etal_IOC_2001.pdf.txtPauloRoberto_Post_etal_IOC_2001.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review
title The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review
spellingShingle The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review
Post, Paulo Roberto
Febre Amarela
Vacina
Imunização
Tensão 17DD
Linhagem de vírus
Yellow fever
Vaccine
17DD strain
Virus lineage
Immunization
title_short The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review
title_full The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review
title_fullStr The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review
title_full_unstemmed The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review
title_sort The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review
author Post, Paulo Roberto
author_facet Post, Paulo Roberto
Carvalho, Ricardo de
Freire, Marcos da Silva
Galler, Ricardo
author_role author
author2 Carvalho, Ricardo de
Freire, Marcos da Silva
Galler, Ricardo
author2_role author
author
author
dc.contributor.author.fl_str_mv Post, Paulo Roberto
Carvalho, Ricardo de
Freire, Marcos da Silva
Galler, Ricardo
dc.subject.other.pt_BR.fl_str_mv Febre Amarela
Vacina
Imunização
Tensão 17DD
Linhagem de vírus
topic Febre Amarela
Vacina
Imunização
Tensão 17DD
Linhagem de vírus
Yellow fever
Vaccine
17DD strain
Virus lineage
Immunization
dc.subject.en.pt_BR.fl_str_mv Yellow fever
Vaccine
17DD strain
Virus lineage
Immunization
description Universidade Federal de Pelotas, Campus Universitário. Instituto de Biologia. Departamento de Microbiologia e Parasitologia, Pelotas, RS, Brasil.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2020-10-23T19:55:49Z
dc.date.available.fl_str_mv 2020-10-23T19:55:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv POST, Paulo Roberto et al. The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review, Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 849-857, Aug. 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44153
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762001000600019
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv POST, Paulo Roberto et al. The Early Use of Yellow Fever Virus Strain 17D for Vaccine Production in Brazil A Review, Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 96, n. 6, p. 849-857, Aug. 2001.
0074-0276
10.1590/S0074-02762001000600019
1678-8060
url https://www.arca.fiocruz.br/handle/icict/44153
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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