Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control

Detalhes bibliográficos
Autor(a) principal: Ferreira, Marcel T.
Data de Publicação: 2015
Outros Autores: Leite, Nathalie C., Cardoso, Claudia R.L., Salles, Gil F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35151
Resumo: Marcel T. Ferreira. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Ferreira, Marcel T.Leite, Nathalie C.Cardoso, Claudia R.L.Salles, Gil F.2019-08-28T12:14:37Z2019-08-28T12:14:37Z2015FERREIRA, Marcel T. et al. Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control: the Rio de Janeiro type 2 diabetes cohort study. Diabetes Care, v. 38, p. 897-904, May 2015.0149-5992https://www.arca.fiocruz.br/handle/icict/3515110.2337/dc14-27911935-5548Marcel T. Ferreira. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-08-28Sem afiliação.Sem afiliação.Sem afiliação.Universidade Federal do Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. School of Medicine. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil .OBJECTIVE: The correlates of serial changes in aortic stiffness in patients with diabetes have never been investigated. We aimed to examine the importance of glycemic control on progression/regression of carotid-femoral pulse wave velocity (cf-PWV) in type 2 diabetes. RESEARCH DESIGN AND METHODS: In a prospective study, two cf-PWV measurements were performed with the Complior equipment in 417 patients with type 2 diabetes over a mean follow-up of 4.2 years. Clinical laboratory data were obtained at baseline and throughout follow-up. Multivariable linear/logistic regressions assessed the independent correlates of changes in cf-PWV. RESULTS: Median cf-PWV increase was 0.11 m/s per year (1.1% per year). Overall, 212 patients (51%) increased/persisted with high cf-PWV, while 205 (49%) reduced/persisted with low cf-PWV. Multivariate linear regression demonstrated direct associations between cf-PWV changes and mean HbA1c during follow-up (partial correlation 0.14, P = 0.005). On logistic regression, a mean HbA1c ‡7.5% (58 mmol/mol) was associated with twofold higher odds of having increased/persistently high cf-PWV during follow-up. Furthermore, the rate of HbA1c reduction relative to baseline levels was inversely associated with cf-PWV changes (partial correlation 20.11, P = 0.011) and associated with reduced risk of having increased/persistently high aortic stiffness (odds ratio 0.82 [95% CI 0.69–0.96]; P = 0.017). Other independent correlates of progression in aortic stiffness were increases in systolic blood pressure and heart rate between the two cf-PWV measurements, older age, female sex, and presence of dyslipidemia and retinopathy. CONCLUSIONS: Better glycemic control, together with reductions in blood pressure and heart rate,was themost important correlate to attenuate/prevent progression of aortic stiffness in patients with type 2 diabetes.engAmerican Diabetes AssociationCorrelates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic controlinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDiabetesType 2 diabetesAortic stiffnessGlycemic controlinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35151/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Ferreira_Marcel_etal_INI_2015.pdfve_Ferreira_Marcel_etal_INI_2015.pdfapplication/pdf777337https://www.arca.fiocruz.br/bitstream/icict/35151/2/ve_Ferreira_Marcel_etal_INI_2015.pdf68f536088865cf45aebe202b3cfa4f86MD52TEXTve_Ferreira_Marcel_etal_INI_2015.pdf.txtve_Ferreira_Marcel_etal_INI_2015.pdf.txtExtracted texttext/plain45388https://www.arca.fiocruz.br/bitstream/icict/35151/3/ve_Ferreira_Marcel_etal_INI_2015.pdf.txt699e365b84aa52291c6575485cc3ee0fMD53icict/351512021-03-24 16:32:36.016oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control
title Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control
spellingShingle Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control
Ferreira, Marcel T.
Diabetes
Type 2 diabetes
Aortic stiffness
Glycemic control
title_short Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control
title_full Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control
title_fullStr Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control
title_full_unstemmed Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control
title_sort Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control
author Ferreira, Marcel T.
author_facet Ferreira, Marcel T.
Leite, Nathalie C.
Cardoso, Claudia R.L.
Salles, Gil F.
author_role author
author2 Leite, Nathalie C.
Cardoso, Claudia R.L.
Salles, Gil F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Ferreira, Marcel T.
Leite, Nathalie C.
Cardoso, Claudia R.L.
Salles, Gil F.
dc.subject.en.pt_BR.fl_str_mv Diabetes
Type 2 diabetes
Aortic stiffness
Glycemic control
topic Diabetes
Type 2 diabetes
Aortic stiffness
Glycemic control
description Marcel T. Ferreira. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-28T12:14:37Z
dc.date.available.fl_str_mv 2019-08-28T12:14:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Marcel T. et al. Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control: the Rio de Janeiro type 2 diabetes cohort study. Diabetes Care, v. 38, p. 897-904, May 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35151
dc.identifier.issn.pt_BR.fl_str_mv 0149-5992
dc.identifier.doi.none.fl_str_mv 10.2337/dc14-2791
dc.identifier.eissn.none.fl_str_mv 1935-5548
identifier_str_mv FERREIRA, Marcel T. et al. Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control: the Rio de Janeiro type 2 diabetes cohort study. Diabetes Care, v. 38, p. 897-904, May 2015.
0149-5992
10.2337/dc14-2791
1935-5548
url https://www.arca.fiocruz.br/handle/icict/35151
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Diabetes Association
publisher.none.fl_str_mv American Diabetes Association
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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