Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study

Detalhes bibliográficos
Autor(a) principal: Cardoso, Claudia R. L.
Data de Publicação: 2015
Outros Autores: Moran, Camila B. M., Marinho, Fernanda S., Ferreira, Marcel T., Salles, Gil F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35154
Resumo: Marcel T. Ferreira. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Cardoso, Claudia R. L.Moran, Camila B. M.Marinho, Fernanda S.Ferreira, Marcel T.Salles, Gil F.2019-08-28T12:57:42Z2019-08-28T12:57:42Z2015CARDOSO, Claudia R. L. et al. Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Diabetologia, v. 58, p. 2161-2168, 2015.0012-186Xhttps://www.arca.fiocruz.br/handle/icict/3515410.1007/s00125-015-3658-91432-0428Marcel T. Ferreira. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-08-28Universidade Federal do Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. School of Medicine. Department of Internal Medicine. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. School of Medicine. Department of Occupational Therapy. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. School of Medicine. Department of Occupational Therapy. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. School of Medicine. Department of Internal Medicine. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. University Hospital Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. School of Medicine. Department of Internal Medicine. Rio de Janeiro, RJ, Brasil.Aims/hypothesis: Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication that is strongly associated with poor glycaemic control and also with a worse prognosis. We aimed to evaluate the predictors of the development and progression of DPN in a cohort of high-risk patients with type 2 diabetes. Methods: In a prospective study, 477 patients with type 2 diabetes were clinically assessed for the presence of DPN at baseline and after a median follow-up of 6.2 years (range 2–10 years). Clinical laboratory data were obtained at study entry and throughout the follow-up. Aortic stiffness was assessed by the carotid–femoral pulse wave velocity (cf-PWV) at baseline. Multivariate Poisson regression analysis was used to examine independent predictors of the development/progression of DPN. Results: At baseline, 135 patients (28%) had DPN, and during follow-up 97 patients (20%) had either a new development or a worsening of DPN. Patients who showed a development or progression of DPN were taller and had a longer duration of diabetes, a greater prevalence of other microvascular complications and hypertension, greater aortic stiffness and poorer glycaemic control than patients who did not have new or progressive neuropathy. After adjustments for the baseline prevalence of DPN, the patient’s age and sex, and the time interval between DPN assessments; an increased aortic stiffness (cf-PWV >10 m/s) were predictive of new/progressive DPN (incidence rate ratio 2.04, 95% CI 1.28, 3.23; p=0.002). Other independent predictors were the mean first-year HbA1c level ( p=0.05), nephropathy ( p=0.006), arterial hypertension ( p=0.06) and height ( p=0.03). Conclusions/interpretation: Increased aortic stiffness at baseline predicts the future development or progression of peripheral neuropathy, independent of diabetic metabolic control, suggesting a physiopathological link between macrovascular and microvascular abnormalities in type 2 diabetes.engSpringer VerlagIncreased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAortic stiffnessDiabetic peripheral neuropathyGlycaemic controlPredictorsType 2 diabetesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35154/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Cardoso_Claudia_etal_INI_2015.pdfve_Cardoso_Claudia_etal_INI_2015.pdfapplication/pdf303542https://www.arca.fiocruz.br/bitstream/icict/35154/2/ve_Cardoso_Claudia_etal_INI_2015.pdfc55347a8ef24fc70438c3e2e236c3ab8MD52TEXTve_Cardoso_Claudia_etal_INI_2015.pdf.txtve_Cardoso_Claudia_etal_INI_2015.pdf.txtExtracted texttext/plain40922https://www.arca.fiocruz.br/bitstream/icict/35154/3/ve_Cardoso_Claudia_etal_INI_2015.pdf.txt52bcc0fc116b3adda58c115a3249d977MD53icict/351542021-03-24 16:32:36.046oai:www.arca.fiocruz.br:icict/35154Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
title Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
spellingShingle Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
Cardoso, Claudia R. L.
Aortic stiffness
Diabetic peripheral neuropathy
Glycaemic control
Predictors
Type 2 diabetes
title_short Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
title_full Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
title_fullStr Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
title_full_unstemmed Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
title_sort Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study
author Cardoso, Claudia R. L.
author_facet Cardoso, Claudia R. L.
Moran, Camila B. M.
Marinho, Fernanda S.
Ferreira, Marcel T.
Salles, Gil F.
author_role author
author2 Moran, Camila B. M.
Marinho, Fernanda S.
Ferreira, Marcel T.
Salles, Gil F.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Claudia R. L.
Moran, Camila B. M.
Marinho, Fernanda S.
Ferreira, Marcel T.
Salles, Gil F.
dc.subject.en.pt_BR.fl_str_mv Aortic stiffness
Diabetic peripheral neuropathy
Glycaemic control
Predictors
Type 2 diabetes
topic Aortic stiffness
Diabetic peripheral neuropathy
Glycaemic control
Predictors
Type 2 diabetes
description Marcel T. Ferreira. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-28T12:57:42Z
dc.date.available.fl_str_mv 2019-08-28T12:57:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARDOSO, Claudia R. L. et al. Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Diabetologia, v. 58, p. 2161-2168, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35154
dc.identifier.issn.pt_BR.fl_str_mv 0012-186X
dc.identifier.doi.none.fl_str_mv 10.1007/s00125-015-3658-9
dc.identifier.eissn.none.fl_str_mv 1432-0428
identifier_str_mv CARDOSO, Claudia R. L. et al. Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Diabetologia, v. 58, p. 2161-2168, 2015.
0012-186X
10.1007/s00125-015-3658-9
1432-0428
url https://www.arca.fiocruz.br/handle/icict/35154
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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