Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?

Detalhes bibliográficos
Autor(a) principal: Bozza, Fernando A.
Data de Publicação: 2005
Outros Autores: Bozza, Patrícia T., Faria Neto, Hugo C. Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/S0074-02762005000900037
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36909
Resumo: niversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil.
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spelling Bozza, Fernando A.Bozza, Patrícia T.Faria Neto, Hugo C. Castro2019-11-06T16:47:45Z2019-11-06T16:47:45Z2005BOZZA, Fernando A.; BOZZA, Patricia T.; FARIA NETO, Hugo C. Castro. Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 217-221, 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/3690910.1590/S0074-027620050009000371678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.SepseBiomarcadoresCitocinasEstratificaçãoSepsisBiomarkersCytokinesStratificationBeyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleniversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Sepsis is a major challenge in medicine. It is a common and frequently fatal infectious condition. The incidence continues to increase, with unacceptably high mortality rates, despite the use of specific antibiotics, aggressive operative intervention, nutritional support, and anti-inflammatory therapies. Typically, septic patients exhibit a high degree of heterogeneity due to variables such as age, weight, gender, the presence of secondary disease, the state of the immune system, and the severity of the infection. We are at urgent need for biomarkers and reliable measurements that can be applied to risk stratification of septic patients and that would easily identify those patients at the highest risk of a poor outcome. Such markers would be of fundamental importance to decision making for early intervention therapy or for the design of septic clinical trials. In the present work, we will review current biomarkers for sepsis severity and especially the use of cytokines as biomarkers with important pathophysiological role.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36909/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHugoCastroNeo_PatriciaBozza_etal_IOC_2005.pdfHugoCastroNeo_PatriciaBozza_etal_IOC_2005.pdfapplication/pdf34549https://www.arca.fiocruz.br/bitstream/icict/36909/2/HugoCastroNeo_PatriciaBozza_etal_IOC_2005.pdf3cb56500833f139d643362952c06aa9cMD52TEXTHugoCastroNeo_PatriciaBozza_etal_IOC_2005.pdf.txtHugoCastroNeo_PatriciaBozza_etal_IOC_2005.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
title Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
spellingShingle Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
Bozza, Fernando A.
Sepse
Biomarcadores
Citocinas
Estratificação
Sepsis
Biomarkers
Cytokines
Stratification
title_short Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
title_full Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
title_fullStr Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
title_full_unstemmed Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
title_sort Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
author Bozza, Fernando A.
author_facet Bozza, Fernando A.
Bozza, Patrícia T.
Faria Neto, Hugo C. Castro
author_role author
author2 Bozza, Patrícia T.
Faria Neto, Hugo C. Castro
author2_role author
author
dc.contributor.author.fl_str_mv Bozza, Fernando A.
Bozza, Patrícia T.
Faria Neto, Hugo C. Castro
dc.subject.other.pt_BR.fl_str_mv Sepse
Biomarcadores
Citocinas
Estratificação
topic Sepse
Biomarcadores
Citocinas
Estratificação
Sepsis
Biomarkers
Cytokines
Stratification
dc.subject.en.pt_BR.fl_str_mv Sepsis
Biomarkers
Cytokines
Stratification
description niversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Unidade de Terapia Intensiva. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-11-06T16:47:45Z
dc.date.available.fl_str_mv 2019-11-06T16:47:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOZZA, Fernando A.; BOZZA, Patricia T.; FARIA NETO, Hugo C. Castro. Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 217-221, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36909
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762005000900037
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv BOZZA, Fernando A.; BOZZA, Patricia T.; FARIA NETO, Hugo C. Castro. Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, suppl. 1, p. 217-221, 2005.
0074-0276
10.1590/S0074-02762005000900037
1678-8060
url https://www.arca.fiocruz.br/handle/icict/36909
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/36909/2/HugoCastroNeo_PatriciaBozza_etal_IOC_2005.pdf
https://www.arca.fiocruz.br/bitstream/icict/36909/3/HugoCastroNeo_PatriciaBozza_etal_IOC_2005.pdf.txt
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