Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32628 |
Resumo: | Universidade de Brasília. Hospital Universitário de Brasília. Departamento de Reumatologia. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil. |
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Ferreira, Clarissa de CastroAzevedo, Ana Carolina CampiPascoal, Vanessa Peruhype MagalhāesReis, Jordana Grazziela Alves Coelho dosAntonelli, Lis Ribeiro do ValleTorres, Karen Cecília de LimaFreire, Larissa ChavesRocha, Ismael Artur da CostaOliveira, Ana Cristina VanderleyMaia, Maria de Lourdes de SousaLima, Sheila Maria Barbosa deDomingues, Carla MagdaCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisMota, Lícia Maria Henrique da2019-04-22T11:59:34Z2019-04-22T11:59:34Z2019FERREIRA, Clarissa de Castro et al. Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis. Arthritis Research and Therapy, v. 21, n. 1, p. 1-12, 2019.1478-6362https://www.arca.fiocruz.br/handle/icict/3262810.1186/s13075-019-1854-6porBMCImunidade celularTerapia imunomoduladoraAnticorpos neutralizantesArtrite reumatoideCellular immunityImmunomodulatory therapyNeutralizing antibodiesRheumatoid arthritisYellow fever vaccineVacina contra febre amarelaImpact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Brasília. Hospital Universitário de Brasília. Departamento de Reumatologia. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Universidade de Brasília. Hospital Universitário de Brasília. Departamento de Reumatologia. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Programa Nacional de Imunizações. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Universidade de Brasília. Hospital Universitário de Brasília. Departamento de Reumatologia. Brasília, DF, Brasil.Background: The 17DD-yellow fever (YF) vaccine induces a long-lasting protective immunity, resulting from humoral and cellular immunological memory. The treatment of rheumatoid arthritis (RA) patients with disease-modifying anti-rheumatic drugs (DMARD) may affect pre-existing 17DD-vaccine protective immunity and increase the risk of acquiring YF infection. Our goal was to determine whether DMARD would affect the duration of YFspecific protective immunity in RA patients. Methods: A total of 122 RA patients, previously immunized with the 17DD-YF vaccine (1–5, 5–9, and ≥ 10 years) and currently under DMARD therapy, were enrolled in the present investigation. Immunomodulatory therapy encompasses the use of conventional synthetic DMARD alone (csDMARD) or combines with biological DMARD (cs+bDMARD). A total of 226 healthy subjects were recruited as a control group (CONT). Neutralizing antibody responses were measured by a plaque-reduction neutralization test (PRNT), and cellular immunity was evaluated by an in vitro 17DD-YF-specific peripheral blood lymphoproliferative assay. Results: The data demonstrated that csDMARD therapy did not affect the duration of protective immunity induced by the 17DD-YF vaccine compared to that of CONT, as both presented a significant time-dependent decline at 10 years after vaccination. Conversely, cs+bDMARD therapy induced a premature depletion in the main determinants of the vaccine protective response, with diminished PRNT seropositivity levels between 5 and 9 years and impaired effector memory in CD8+ T cells as early as 1–5 years after 17DD-YF vaccination. Conclusions: These findings could support changing the vaccination schedule of this population, with the possibility of a planned booster dose upon the suspension of bDMARD in cases where this is allowed, even before 10 years following 17DD-YF vaccination. The benefit of a planned booster dose should be evaluated in further studies. Trial registration: RBR-946bv5. Date of registration: March 05, 2018. 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| dc.title.pt_BR.fl_str_mv |
Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis |
| title |
Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis |
| spellingShingle |
Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis Ferreira, Clarissa de Castro Imunidade celular Terapia imunomoduladora Anticorpos neutralizantes Artrite reumatoide Cellular immunity Immunomodulatory therapy Neutralizing antibodies Rheumatoid arthritis Yellow fever vaccine Vacina contra febre amarela |
| title_short |
Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis |
| title_full |
Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis |
| title_fullStr |
Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis |
| title_full_unstemmed |
Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis |
| title_sort |
Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis |
| author |
Ferreira, Clarissa de Castro |
| author_facet |
Ferreira, Clarissa de Castro Azevedo, Ana Carolina Campi Pascoal, Vanessa Peruhype Magalhāes Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Torres, Karen Cecília de Lima Freire, Larissa Chaves Rocha, Ismael Artur da Costa Oliveira, Ana Cristina Vanderley Maia, Maria de Lourdes de Sousa Lima, Sheila Maria Barbosa de Domingues, Carla Magda Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Mota, Lícia Maria Henrique da |
| author_role |
author |
| author2 |
Azevedo, Ana Carolina Campi Pascoal, Vanessa Peruhype Magalhāes Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Torres, Karen Cecília de Lima Freire, Larissa Chaves Rocha, Ismael Artur da Costa Oliveira, Ana Cristina Vanderley Maia, Maria de Lourdes de Sousa Lima, Sheila Maria Barbosa de Domingues, Carla Magda Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Mota, Lícia Maria Henrique da |
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author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ferreira, Clarissa de Castro Azevedo, Ana Carolina Campi Pascoal, Vanessa Peruhype Magalhāes Reis, Jordana Grazziela Alves Coelho dos Antonelli, Lis Ribeiro do Valle Torres, Karen Cecília de Lima Freire, Larissa Chaves Rocha, Ismael Artur da Costa Oliveira, Ana Cristina Vanderley Maia, Maria de Lourdes de Sousa Lima, Sheila Maria Barbosa de Domingues, Carla Magda Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Mota, Lícia Maria Henrique da |
| dc.subject.other.pt_BR.fl_str_mv |
Imunidade celular Terapia imunomoduladora Anticorpos neutralizantes Artrite reumatoide |
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Imunidade celular Terapia imunomoduladora Anticorpos neutralizantes Artrite reumatoide Cellular immunity Immunomodulatory therapy Neutralizing antibodies Rheumatoid arthritis Yellow fever vaccine Vacina contra febre amarela |
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Cellular immunity Immunomodulatory therapy Neutralizing antibodies Rheumatoid arthritis Yellow fever vaccine Vacina contra febre amarela |
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Universidade de Brasília. Hospital Universitário de Brasília. Departamento de Reumatologia. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil. |
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2019 |
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2019-04-22T11:59:34Z |
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2019-04-22T11:59:34Z |
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2019 |
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info:eu-repo/semantics/article |
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FERREIRA, Clarissa de Castro et al. Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis. Arthritis Research and Therapy, v. 21, n. 1, p. 1-12, 2019. |
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1478-6362 |
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10.1186/s13075-019-1854-6 |
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FERREIRA, Clarissa de Castro et al. Impact of synthetic and biological immunomodulatory therapy on the duration of 17DD yellow fever vaccine-induced immunity in rheumatoid arthritis. Arthritis Research and Therapy, v. 21, n. 1, p. 1-12, 2019. 1478-6362 10.1186/s13075-019-1854-6 |
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