Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo de conferência |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60915 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Cazote, A. da SilvaCaldas, L. Nery da SilvaLima, D. Granato da CostaAlmeida, D. VictalinaPilotto, José HenriqueLima, S.M. BarbosaSoares, A. de Souza AzevedoMendes, Y. da SilvaFilippis, A. BispoMorata, MichelleBrandão, Luciana Gomes PedroDias, M.Cardoso, Sandra WagnerGrinsztejn, BeatrizCamacho, L. AntônioCoelho, Lara EstevesCortes, F. HeloiseScott-Algara, D.Gripp, C.B. Wagner Giacoia2023-10-25T15:34:52Z2023-10-25T15:34:52Z2023CAZOTE, A. da Silva et al. Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403. In: IAS CONFERENCE ON HIV SCIENCE, 12., Brisbane, Australia. [Abstracts...]. Australia, 2023. 1 p.https://www.arca.fiocruz.br/handle/icict/60915engInternational AIDS SocietyFebre amarelaPessoas que vivem com HIVAnticorpos neutralizantesYellow FeverPeople living with HIVNeutralizing antibodiesDecrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403Diminuição dos títulos de anticorpos neutralizantes da febre amarela um ano após a vacinação estar relacionada a diferentes células NK repertório nos controles PLW e não -HIV - ANRS12403info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Virológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Virológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia Virológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Imunização e Vigilância em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Pasteur Institute. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Background: Yellow fever (YF) vaccine has been successfully used to control YF disease and prevent new outbreaks. The 17DD YF vaccine is considered a safe and highly effective vaccine in people living with HIV (PLWH), but the immunogenicity mechanisms are not completely understood. This study hypothesized that, despite HIV viral load (VL) suppression, PLWH could present reduced production and maintenance of YF-neutralizing antibodies (NAbs) and that NK cells different repertoire could participate in this process. Methods: This study was nested in a longitudinal study that investigated YF vaccine safety and immunogenicity in PLWH and non-HIV controls (CTRL). NK cells repertoire was evaluated in PLWH with baseline CD4+ T cell counts = 200 cells/mm³ and suppressed VL (n=25), and in CTRL (n=16), by flow cytometry, at pre-vaccination (Day 0), and at three moments post-vaccination (Days 5, 30 and 365). YF vaccine immunogenicity was evaluated by Nab levels measured through a micro plaque reduction neutralization test (µPRNT, cut-off = 1:100) at Days 30 and 365. For the analysis, all participants were grouped regardless HIV status and according to Nab titers at Day 365 as: low (>1:100 and < 1:500), moderate (=500 and <1000) and high (=1000). Results: YF vaccine resulted in protective Nab titers at Day 30 in all participants, which decreased after one year, regardless of HIV status or CD4+ T cells counts. Interestingly, the frequencies of NKp30+ and NKG2A+ NK cells were significantly lower at D0 among the low Nabs participants, compared to individuals having moderate and high NAbs titers (p<0,05). Such lower frequencies were significant in all the moments, compared to the moderate Nabs participants (p<0,05). Conclusions: Although serological correlates of protection have not been established, higher YF NAbs titers plausibly indicate longer protection against disease. NKp30 is an important NK activation receptor while NKG2A is related to high responsive educated NK cells. Early activation of NK cells can engage pathways involving B cells response, wich leads to humoral immunity against viruses (due to infections or vaccine). Our results suggest that NK cell repertoire presented before vaccination could impact YF vaccine immunogenicity and long term duration of the NAbs protection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60915/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDecrease_Lara_Coelho_2023.pdfDecrease_Lara_Coelho_2023.pdfapplication/pdf741462https://www.arca.fiocruz.br/bitstream/icict/60915/2/Decrease_Lara_Coelho_2023.pdf9885195e193056cfc0cdcf81f82b6e00MD52icict/609152023-10-25 12:38:36.201oai:www.arca.fiocruz.br:icict/60915Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-25T15:38:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403 |
| dc.title.alternative.en_US.fl_str_mv |
Diminuição dos títulos de anticorpos neutralizantes da febre amarela um ano após a vacinação estar relacionada a diferentes células NK repertório nos controles PLW e não -HIV - ANRS12403 |
| title |
Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403 |
| spellingShingle |
Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403 Cazote, A. da Silva Febre amarela Pessoas que vivem com HIV Anticorpos neutralizantes Yellow Fever People living with HIV Neutralizing antibodies |
| title_short |
Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403 |
| title_full |
Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403 |
| title_fullStr |
Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403 |
| title_full_unstemmed |
Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403 |
| title_sort |
Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403 |
| author |
Cazote, A. da Silva |
| author_facet |
Cazote, A. da Silva Caldas, L. Nery da Silva Lima, D. Granato da Costa Almeida, D. Victalina Pilotto, José Henrique Lima, S.M. Barbosa Soares, A. de Souza Azevedo Mendes, Y. da Silva Filippis, A. Bispo Morata, Michelle Brandão, Luciana Gomes Pedro Dias, M. Cardoso, Sandra Wagner Grinsztejn, Beatriz Camacho, L. Antônio Coelho, Lara Esteves Cortes, F. Heloise Scott-Algara, D. Gripp, C.B. Wagner Giacoia |
| author_role |
author |
| author2 |
Caldas, L. Nery da Silva Lima, D. Granato da Costa Almeida, D. Victalina Pilotto, José Henrique Lima, S.M. Barbosa Soares, A. de Souza Azevedo Mendes, Y. da Silva Filippis, A. Bispo Morata, Michelle Brandão, Luciana Gomes Pedro Dias, M. Cardoso, Sandra Wagner Grinsztejn, Beatriz Camacho, L. Antônio Coelho, Lara Esteves Cortes, F. Heloise Scott-Algara, D. Gripp, C.B. Wagner Giacoia |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cazote, A. da Silva Caldas, L. Nery da Silva Lima, D. Granato da Costa Almeida, D. Victalina Pilotto, José Henrique Lima, S.M. Barbosa Soares, A. de Souza Azevedo Mendes, Y. da Silva Filippis, A. Bispo Morata, Michelle Brandão, Luciana Gomes Pedro Dias, M. Cardoso, Sandra Wagner Grinsztejn, Beatriz Camacho, L. Antônio Coelho, Lara Esteves Cortes, F. Heloise Scott-Algara, D. Gripp, C.B. Wagner Giacoia |
| dc.subject.other.en_US.fl_str_mv |
Febre amarela Pessoas que vivem com HIV Anticorpos neutralizantes |
| topic |
Febre amarela Pessoas que vivem com HIV Anticorpos neutralizantes Yellow Fever People living with HIV Neutralizing antibodies |
| dc.subject.en.en_US.fl_str_mv |
Yellow Fever People living with HIV Neutralizing antibodies |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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2023 |
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2023-10-25T15:34:52Z |
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2023-10-25T15:34:52Z |
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2023 |
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CAZOTE, A. da Silva et al. Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403. In: IAS CONFERENCE ON HIV SCIENCE, 12., Brisbane, Australia. [Abstracts...]. Australia, 2023. 1 p. |
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https://www.arca.fiocruz.br/handle/icict/60915 |
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CAZOTE, A. da Silva et al. Decrease of Yellow Fever neutralizing antibody titers one year after vaccination is related to different NK cells repertoire in PLWH and non-HIV controls - ANRS12403. In: IAS CONFERENCE ON HIV SCIENCE, 12., Brisbane, Australia. [Abstracts...]. Australia, 2023. 1 p. |
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International AIDS Society |
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International AIDS Society |
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