Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Xabregas, Lilyane Amorim
Data de Publicação: 2022
Outros Autores: Hanna, Fabíola Silva Alves, Magalhães-Gama, Fábio, Souza, Gláucia Lima, Pereira, Daniele Sá, Lima, Amanda Barros de, Toro, Diana Mota, Santiago, Mirian Rodrigues Ribeiro, Passos, Leny Nascimento da Motta, Tarragô, Andréa Monteiro, Costa, Allyson Guimarães
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56839
Resumo: Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil
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spelling Xabregas, Lilyane AmorimHanna, Fabíola Silva AlvesMagalhães-Gama, FábioSouza, Gláucia LimaPereira, Daniele SáLima, Amanda Barros deToro, Diana MotaSantiago, Mirian Rodrigues RibeiroPassos, Leny Nascimento da MottaTarragô, Andréa MonteiroCosta, Allyson Guimarães2023-02-02T17:05:45Z2023-02-02T17:05:45Z2022XABREGAS, Lilyane Amorim et al. Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon. Sci Rep., v. 12, n. 1, 15159, 2022. doi: 10.1038/s41598-022-19130-7.2045-2322https://www.arca.fiocruz.br/handle/icict/56839engNature Publishing GroupAssociation of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM BrazilUniversidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde.Belo Horizonte, BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/ Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM BrazilUniversidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/ Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/ Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Rede Genômica de Vigilância em Saúde do Amazonas. Manaus, AM BrazilUniversidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, BrazilAcute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children in childhood. Single-nucleotide polymorphism (SNPs) in key molecules of the immune system, such as Toll-like receptors (TLRs) and CD14 molecules, are associated with the development of several diseases. However, their role in ALL is unknown. A case–control study was performed with 152 ALL patients and 187 healthy individuals to investigate the role of SNPs in TLRs and the CD14 gene in ALL. In this study, TLR6 C > T rs5743810 [OR: 3.20, 95% CI: 1.11–9.17, p = 0.003) and TLR9 C > T rs187084 (OR: 2.29, 95% CI: 1.23–4.26, p = 0.000) seems to be a risk for development of ALL. In addition, the TLR1 T > G rs5743618 and TLR6 C > T rs5743810 polymorphisms with protection against death (OR: 0.17, 95% IC: 0.04–0.79, p = 0.008; OR: 0.48, 95% IC: 0.24–0.94, p = 0.031, respectively). Our results show that SNPs in TLRs genes may be involved in the pathogenesis of ALL and may influence clinical prognosis; however, further studies are necessary to elucidate the role of TLR1, TLR4, TLR5, TLR6, TLR9 and CD14 polymorphisms in this disease.ImmunologyGeneticsImmunogeneticsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56839/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAssociation of Toll-like receptors polymorphisms.pdfAssociation of Toll-like receptors polymorphisms.pdfapplication/pdf1153341https://www.arca.fiocruz.br/bitstream/icict/56839/2/Association%20of%20Toll-like%20receptors%20polymorphisms.pdf437d63a4279b857dcbe57809044a196eMD52icict/568392023-02-02 14:05:46.266oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon
title Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon
spellingShingle Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon
Xabregas, Lilyane Amorim
Immunology
Genetics
Immunogenetics
title_short Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon
title_full Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon
title_fullStr Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon
title_full_unstemmed Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon
title_sort Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon
author Xabregas, Lilyane Amorim
author_facet Xabregas, Lilyane Amorim
Hanna, Fabíola Silva Alves
Magalhães-Gama, Fábio
Souza, Gláucia Lima
Pereira, Daniele Sá
Lima, Amanda Barros de
Toro, Diana Mota
Santiago, Mirian Rodrigues Ribeiro
Passos, Leny Nascimento da Motta
Tarragô, Andréa Monteiro
Costa, Allyson Guimarães
author_role author
author2 Hanna, Fabíola Silva Alves
Magalhães-Gama, Fábio
Souza, Gláucia Lima
Pereira, Daniele Sá
Lima, Amanda Barros de
Toro, Diana Mota
Santiago, Mirian Rodrigues Ribeiro
Passos, Leny Nascimento da Motta
Tarragô, Andréa Monteiro
Costa, Allyson Guimarães
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Xabregas, Lilyane Amorim
Hanna, Fabíola Silva Alves
Magalhães-Gama, Fábio
Souza, Gláucia Lima
Pereira, Daniele Sá
Lima, Amanda Barros de
Toro, Diana Mota
Santiago, Mirian Rodrigues Ribeiro
Passos, Leny Nascimento da Motta
Tarragô, Andréa Monteiro
Costa, Allyson Guimarães
dc.subject.en.en_US.fl_str_mv Immunology
Genetics
Immunogenetics
topic Immunology
Genetics
Immunogenetics
description Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM Brazil/Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-02-02T17:05:45Z
dc.date.available.fl_str_mv 2023-02-02T17:05:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv XABREGAS, Lilyane Amorim et al. Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon. Sci Rep., v. 12, n. 1, 15159, 2022. doi: 10.1038/s41598-022-19130-7.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56839
dc.identifier.issn.en_US.fl_str_mv 2045-2322
identifier_str_mv XABREGAS, Lilyane Amorim et al. Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon. Sci Rep., v. 12, n. 1, 15159, 2022. doi: 10.1038/s41598-022-19130-7.
2045-2322
url https://www.arca.fiocruz.br/handle/icict/56839
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56839/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56839/2/Association%20of%20Toll-like%20receptors%20polymorphisms.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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