Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax
| Autor(a) principal: | |
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| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15010 |
Resumo: | Universidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, Brasil |
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Cassiano, Gustavo CapattiFurini, Adriana Antonia CruzCapobianco, Marcela PetroliniMelo, Luciane Moreno StortiCunha, Maristela Gomes daKano, Flora SatikoCarvalho, Luzia HelenaSoares, Irene da SilvaSantos, Sidney Emanuel Batista dosPóvoa, Marinete MarinsMachado, Ricardo Luiz Dantas2016-07-20T17:49:33Z2016-07-20T17:49:33Z2016Cassiano, Gustavo Capatti et al. Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax. PLoS One, vol. 11, n. 2, p. e0149581, 20161932-6203https://www.arca.fiocruz.br/handle/icict/1501010.1371/journal.pone.0149581engPublic Library of SciencePolymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivaxinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, BrasilFaculdade de Medicina. Departamento de Dermatologia, Doenças Infecciosas e Parasitarias. São José do Rio Preto, SP, BrasilUniversidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, BrasilUniversidade Federal de Sergipe. Departamento de Biologia. Aracaju, SE, BrasilUniversidade Federal do Pará. Instituto de Ciencias Biologicas. Laboratório f Microbiologia e Imunologia. Belém, PA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Malaria. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Malaria. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Malaria. Belo Horizonte, MG, BrasilUniversidade de São Paulo. Faculdade de Ciencias Farmaceuticas. Departamento de Analises Toxicologicas e Clinicas. São Paulo, SP, BrasilUniversidade Federal do Pará. Laboratorio de Genetica Medica e Humana. Belém, PA, BrazilFundação Oswaldo Cruz. Instituto Evandro Chagas.Departamento de Parasitologia. Laboratorio de Pesquisa Básica em Malaria. Belém, PA, BrasilUniversidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, Brasil/ Fundação Oswaldo Cruz. Instituto Evandro Chagas.Departamento de Parasitologia. Laboratorio de Pesquisa Básica em Malaria. Belém, PA, BrasilThe development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of the human host. Therefore, this study aimed to investigate the influence of polymorphisms in genes involved in the costimulation of B-lymphocytes in the naturally acquired humoral immune response against proteins of the asexual stage of Plasmodium vivax. A total of 319 individuals living in an area of malaria transmission in the Brazilian Amazon were genotyped for four SNPs in the genes CD40, CD40L, BLYS and CD86. In addition, IgG antibodies against P. vivax apical membrane antigen 1 (PvAMA-1), Duffy binding protein (PvDBP) and merozoite surface protein 1 (PvMSP-119) were detected by ELISA. The SNP BLYS -871C>T was associated with the frequency of IgG responders to PvAMA-1 and PvMSP-119. The SNP CD40 -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A. These data may help to elucidate the immunological aspects of vivax malaria and consequently assist in the design of malaria vaccinesAntibodies, Protozoan/immunologyAntigens, CD/geneticsAntigens, CD/immunologyImmunoglobulin G/immunologyMalaria, Vivax/geneticsMalaria, Vivax/immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15010/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDFve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDFapplication/pdf1919155https://www.arca.fiocruz.br/bitstream/icict/15010/2/ve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF7b126cea1b5944636f3c8cc75665d756MD52TEXTve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF.txtve_Cassiano_Gustavo_Polymorphisms_CPqRR_2016.PDF.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax |
| title |
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax |
| spellingShingle |
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax Cassiano, Gustavo Capatti Antibodies, Protozoan/immunology Antigens, CD/genetics Antigens, CD/immunology Immunoglobulin G/immunology Malaria, Vivax/genetics Malaria, Vivax/immunology |
| title_short |
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax |
| title_full |
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax |
| title_fullStr |
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax |
| title_full_unstemmed |
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax |
| title_sort |
Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax |
| author |
Cassiano, Gustavo Capatti |
| author_facet |
Cassiano, Gustavo Capatti Furini, Adriana Antonia Cruz Capobianco, Marcela Petrolini Melo, Luciane Moreno Storti Cunha, Maristela Gomes da Kano, Flora Satiko Carvalho, Luzia Helena Soares, Irene da Silva Santos, Sidney Emanuel Batista dos Póvoa, Marinete Marins Machado, Ricardo Luiz Dantas |
| author_role |
author |
| author2 |
Furini, Adriana Antonia Cruz Capobianco, Marcela Petrolini Melo, Luciane Moreno Storti Cunha, Maristela Gomes da Kano, Flora Satiko Carvalho, Luzia Helena Soares, Irene da Silva Santos, Sidney Emanuel Batista dos Póvoa, Marinete Marins Machado, Ricardo Luiz Dantas |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cassiano, Gustavo Capatti Furini, Adriana Antonia Cruz Capobianco, Marcela Petrolini Melo, Luciane Moreno Storti Cunha, Maristela Gomes da Kano, Flora Satiko Carvalho, Luzia Helena Soares, Irene da Silva Santos, Sidney Emanuel Batista dos Póvoa, Marinete Marins Machado, Ricardo Luiz Dantas |
| dc.subject.en.pt_BR.fl_str_mv |
Antibodies, Protozoan/immunology Antigens, CD/genetics Antigens, CD/immunology Immunoglobulin G/immunology Malaria, Vivax/genetics Malaria, Vivax/immunology |
| topic |
Antibodies, Protozoan/immunology Antigens, CD/genetics Antigens, CD/immunology Immunoglobulin G/immunology Malaria, Vivax/genetics Malaria, Vivax/immunology |
| description |
Universidade Estadual Paulista. Departamento de Biologia. São José do Rio Preto, SP, Brasil |
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2016 |
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2016-07-20T17:49:33Z |
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2016-07-20T17:49:33Z |
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2016 |
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Cassiano, Gustavo Capatti et al. Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax. PLoS One, vol. 11, n. 2, p. e0149581, 2016 |
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https://www.arca.fiocruz.br/handle/icict/15010 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0149581 |
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Cassiano, Gustavo Capatti et al. Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood–Stage Proteins of Plasmodium vivax. PLoS One, vol. 11, n. 2, p. e0149581, 2016 1932-6203 10.1371/journal.pone.0149581 |
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