Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection

Detalhes bibliográficos
Autor(a) principal: Santos, Jairo Ivo dos
Data de Publicação: 1989
Outros Autores: Campos, Deise Luci, Castro, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43202
Resumo: Com o objetivo de avaliar a resposta de anticorpos da classe IgG a componentes estruturais do vírus, 85 soros de pacientes brasileiros, compreendendo todo o espectro da infecção pelo HIV foram analisados pela técnica de Western blot. Os soros confirmados como positivos pelas técnicas de imunofluorescência indireta e imunoenzimática. Embora os soros de alguns pacientes estudados reagissem menos intensamente com o polipeptídeo de 55 KDa, não observamos nenhuma diferença de reatividade entre os soros de pacientes com as diversas forma clínicas. Entretanto, a grande freqüência de reatividade ao polipeptídeo de 24 KDa nos pacientes com AIDS sugere que o padrão de resposta imune seja similar aos pacientes Africanos.
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spelling Santos, Jairo Ivo dosCampos, Deise LuciCastro, Bernardo Galvão2020-09-06T18:35:46Z2020-09-06T18:35:46Z1989SANTOS, Jairo Ivo dos; CAMPOS, Deise Luci; CASTRO, Bernardo Galvão. Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazlians with different clinical forms of HIV infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 1, p. 9-11, jan./mar. 1989.0074-0276https://www.arca.fiocruz.br/handle/icict/4320210.1590/S0074-027619890001000031678-8060Com o objetivo de avaliar a resposta de anticorpos da classe IgG a componentes estruturais do vírus, 85 soros de pacientes brasileiros, compreendendo todo o espectro da infecção pelo HIV foram analisados pela técnica de Western blot. Os soros confirmados como positivos pelas técnicas de imunofluorescência indireta e imunoenzimática. Embora os soros de alguns pacientes estudados reagissem menos intensamente com o polipeptídeo de 55 KDa, não observamos nenhuma diferença de reatividade entre os soros de pacientes com as diversas forma clínicas. Entretanto, a grande freqüência de reatividade ao polipeptídeo de 24 KDa nos pacientes com AIDS sugere que o padrão de resposta imune seja similar aos pacientes Africanos.In order to investigate the IgG HIV-1 antibodies rectivity to structural components of the virus, 85 sera from infected Brazilians, comprising the total spectrum of HIV infection, were analysed by Western blot assay. The sera were confirmed as being positive to HIV with enzyme linked immuno assay (ELISA) and indirect immunofluorescence (IIF). Although the sera from patients reacted less intensively to the gag polypeptide of 55KDa, no distinctive antigen reaction patterns were observed between sera patients with different clinical forms. Because of the higher frequency of reactivity to the gag p24 in AIDS patients, the patterns of anti-HIV IgG responses are similar to those observed in their African counterparts.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. WHO Collaborating Centre on AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. WHO Collaborating Centre on AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia. WHO Collaborating Centre on AIDS. Rio de Janeiro, RJ, Brasil.engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.AIDSHIVSorologiaMancha ocidentalAIDSHIVSerologyWestern blotPatterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43202/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJairoIvoSantos_BernardoGalvao_etal_IOC_1989.pdfJairoIvoSantos_BernardoGalvao_etal_IOC_1989.pdfapplication/pdf145030https://www.arca.fiocruz.br/bitstream/icict/43202/2/JairoIvoSantos_BernardoGalvao_etal_IOC_1989.pdf50696b9cf78d3694faa3b462c323ddf8MD52TEXTJairoIvoSantos_BernardoGalvao_etal_IOC_1989.pdf.txtJairoIvoSantos_BernardoGalvao_etal_IOC_1989.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection
title Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection
spellingShingle Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection
Santos, Jairo Ivo dos
AIDS
HIV
Sorologia
Mancha ocidental
AIDS
HIV
Serology
Western blot
title_short Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection
title_full Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection
title_fullStr Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection
title_full_unstemmed Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection
title_sort Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazilians with different clinical forms of HIV infection
author Santos, Jairo Ivo dos
author_facet Santos, Jairo Ivo dos
Campos, Deise Luci
Castro, Bernardo Galvão
author_role author
author2 Campos, Deise Luci
Castro, Bernardo Galvão
author2_role author
author
dc.contributor.author.fl_str_mv Santos, Jairo Ivo dos
Campos, Deise Luci
Castro, Bernardo Galvão
dc.subject.other.pt_BR.fl_str_mv AIDS
HIV
Sorologia
Mancha ocidental
topic AIDS
HIV
Sorologia
Mancha ocidental
AIDS
HIV
Serology
Western blot
dc.subject.en.pt_BR.fl_str_mv AIDS
HIV
Serology
Western blot
description Com o objetivo de avaliar a resposta de anticorpos da classe IgG a componentes estruturais do vírus, 85 soros de pacientes brasileiros, compreendendo todo o espectro da infecção pelo HIV foram analisados pela técnica de Western blot. Os soros confirmados como positivos pelas técnicas de imunofluorescência indireta e imunoenzimática. Embora os soros de alguns pacientes estudados reagissem menos intensamente com o polipeptídeo de 55 KDa, não observamos nenhuma diferença de reatividade entre os soros de pacientes com as diversas forma clínicas. Entretanto, a grande freqüência de reatividade ao polipeptídeo de 24 KDa nos pacientes com AIDS sugere que o padrão de resposta imune seja similar aos pacientes Africanos.
publishDate 1989
dc.date.issued.fl_str_mv 1989
dc.date.accessioned.fl_str_mv 2020-09-06T18:35:46Z
dc.date.available.fl_str_mv 2020-09-06T18:35:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, Jairo Ivo dos; CAMPOS, Deise Luci; CASTRO, Bernardo Galvão. Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazlians with different clinical forms of HIV infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 1, p. 9-11, jan./mar. 1989.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43202
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761989000100003
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv SANTOS, Jairo Ivo dos; CAMPOS, Deise Luci; CASTRO, Bernardo Galvão. Patterns of serologic response to human immunodeficiency virus type 1 (HIV-1) in brazlians with different clinical forms of HIV infection. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 84, n. 1, p. 9-11, jan./mar. 1989.
0074-0276
10.1590/S0074-02761989000100003
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43202
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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